Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou
Fabienne Marie Soudre,
Raoul Karfo,
Alice Kiba,
Arnaud Kouraogo,
Rachid Sougue,
Elie Kabre,
Jean Sakande
Issue:
Volume 11, Issue 2, June 2023
Pages:
15-21
Received:
10 May 2023
Accepted:
13 June 2023
Published:
27 June 2023
Abstract: Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) of Ouagadougou, Burkina Faso. A retrospective descriptive and analytical study was therefore conducted over a period of 3 years at CHUP-CDG. It was performed in the pediatric, intensive care and laboratory departments of the CHUP-CDG, and involved children aged from 0 to 15 years with complete clinical records. A total of 193 patients were included, with a mean age of 18.82±24.85 months and M/F sex ratio of 1.38. The hospital incidence of AAP was 2.43% and the mortality rate 16.06%. Phytomedicinal intoxications were the most common (39.38%), followed by caustic products (19.69%). On admission, serum electrolytes showed hypobicarbonatemia (64.23%), hyperchloremia (55.24%), hyponatremia (33.78%), hypoproteinemia (21.47%) and hyperkalemia (12.16%). At control, hypobicarbonatemia (28.57%), hyperchloremia (75%), hypoproteinemia (28.57%), hyperkalemia (12.50%) and here hypernatremia (25%) were found. The deceased patients had significantly lower natremia (p=0.0442), chloremia (p=0.0007) and proteinemia (p=0.0004) than the other patients in the study. The high death rate was related to herbal medicines and caustic intoxications. Many hydroelectric disorders were found in the study. These disorders could be explain par digestive losses. Indeed, the main clinical signs found in the study were vomiting and diarrhea in children. In addition, acute renal failure in patients could also explain these ionic disturbances. AAP are at the root of multiple ionic disorders, which may be responsible for life-threatening complications in patients.
Abstract: Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHU...
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Preparation, Antibacterial Activity, MIC and MBC of Black Soup Against Staphylococcus aureus and Salmonella typhi
Aigbogun Ighodaro Edwin,
Bakare Akpata Osarobo,
Sarah Adesuwa Evbuomwan,
Ojeifo Stephenson Babatunde,
Iyare Harrison,
Ajenu Christiana,
Apieghiokhia Vivian,
Ikphere Favour,
Daniel Odion Anita
Issue:
Volume 11, Issue 2, June 2023
Pages:
22-28
Received:
8 September 2022
Accepted:
21 September 2022
Published:
6 July 2023
Abstract: Antibacterial activity of black soup against Staphylococcus aureus and Salmonella typhi was studied. The reason for this research was to proof the hypothesis which state that the soup has antibacterial property. Black soup was prepared in the lab by the combination of bitter leaf, scent leaf, uziza leaf with culinary effect of salt, knor maggie cube and palm oil. The soup was moltenized to crude extract and placed in a sterile universal container prior use for antibacterial screening. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was determined. Molecular technique was employed for the identification of S. aureus while Analytical Profile Index (API) kit was used for the identification of S. typhi. The Zone of Inhibition ZOI was 15.54mm - 12.98mm for S. aureus, while Salmonella typhi was 11.01mm – 21.05mm. Ciprotab was used as a positive control while Dimethyl Sulfoxide (DMSO) was used a negative control for the sensitivity. Minimum Inhibitory Concentration (MIC) was 250mg/ml for both bacterial isolate. There was no Minimum Bactericidal concentration for both isolate. This result proofs that the nutritive black soup has antibacterial property though bacteriostatic. Higher concentration of the soup against the isolates can be done to validate the pharmaceutical action of the black soup.
Abstract: Antibacterial activity of black soup against Staphylococcus aureus and Salmonella typhi was studied. The reason for this research was to proof the hypothesis which state that the soup has antibacterial property. Black soup was prepared in the lab by the combination of bitter leaf, scent leaf, uziza leaf with culinary effect of salt, knor maggie cub...
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