Modern Chemistry

Special Issue

Synthesis and Microbial Screening of Coordination and Organic Compounds

  • Submission Deadline: Dec. 20, 2014
  • Status: Submission Closed
  • Lead Guest Editor: Mohammad Nasir
About This Special Issue
The discovery and development of antibiotics are among the most powerful and successful achievements of modern science and technology for the control of infectious diseases. However, the increasing microbial resistance to antibiotics in use nowadays necessitates the search for new compounds with potential effects against pathogenic bacteria. The most spectacular advances in medicinal chemistry have been made when nitrogen and sulphur containing compounds with heterocyclic, aromatic and heteroaromatic nucleus played an important role in regulating biological activities. When heterocyclic part like imidazole, nitromidazole etc. becomes attached to carbohydrate, their efficiency to inhibit fungus or bacteria sharply increased. Extensive investigations in the field of Schiff bases have been reported. Many Schiff bases are known to be medicinally important and are used to design medicinal compounds. Schiff bases appear to be an important intermediate in a number of enzymatic reactions involving interaction of an enzyme with an amino or a carbonyl group of the substrate. Schiff-base ligands with heterocyclic molecule and/or containing heteroatoms such as N, O, and S show a broad biological activity. Nitro and halo derivatives of Schiff bases are reported to have antimicrobial and antitumor activities. Schiff-base complexes are explored to DNA binding and cleavage and hence have been regarded as models for enzymes such as urease.

We invite investigators to contribute original research articles as well as review articles focused on new synthesis in coordination and organic compounds and their microbial studies.

Potential topics include the following:
1. Synthesis and characterization of coordination compounds
2. Synthesis and characterization of organic compounds
3. Isolation and characterization of natural products
4. Their application in antimicrobial, antitumor, anticancer, DNA cleavage studies etc.
Lead Guest Editor
  • Mohammad Nasir

    Department of Chemistry, University of Chittagong, Chittagong, Bangladesh

Guest Editors
  • Shreekant Deshpande

    Analytical Department, Eutech Scientific Services, INC, Higland Park, United States

  • Nikhil Madadi

    University of Arkansas for Medical Sciences, United States

  • Rajavel Rangappan

    Department of Chemistry, Periyar University, Salem, India

  • Md. Mosharef Hossain Bhuiyan

    Department of Chemistry, University of Chittagong, Bangladesh, Bangladesh

Published Articles
  • Synthesis and Characterization of Metal Complexes of Schiff's Base Ligands Derived from 4-Carboxy Hydrazide-5, 6-Diphenyl-3[2-H]Pyridazone

    Faten Z. Mahmoud , Atef A. T. Ramadan , Mohamed M. Mahmoud , Fouz M. Omar

    Issue: Volume 3, Issue 1-1, January 2015
    Pages: 15-26
    Received: Oct. 11, 2014
    Accepted: Feb. 13, 2015
    Published: Feb. 27, 2015
    DOI: 10.11648/j.mc.s.2015030101.13
    Downloads:
    Views:
    Abstract: A new ligand, 4-[carboxy-α-(2-hydroxyphenyl) ethylidene hydrazide-5,6-diphenyl-3(2H) pyridazinone (CHDP), were synthesized and characterized by 1H-NMR, IR spectra and elemental analysis. The dissociation equilibrium constant of CHEDP as well as the equilibrium constant for different M+n-CHEDP complexes were reported at different temperatures in 75... Show More
  • Pb(II) Complexes of Schiff Bases Derived from Benzoylhydrazine as the Antibacterial Agents

    Mohammad Nasir Uddin , Md. Abdus Salam , Jannat Sultana

    Issue: Volume 3, Issue 1-1, January 2015
    Pages: 7-14
    Received: Dec. 20, 2014
    Accepted: Dec. 23, 2014
    Published: Jan. 27, 2015
    DOI: 10.11648/j.mc.s.2015030101.12
    Downloads:
    Views:
    Abstract: Some Pb(II) complexes of dibasic tridentate Schiff base ligands derived from aldehydes/ketones and benzoylhydrazine have been synthesized and characterized by some physico-chemical studies; elemental, spectral (IR, UV, NMR, Mass), magnetic, and conductance analyses. The CHN elemental analysis data showed the formation of 1:1 [M:L] complexes. The ob... Show More
  • Thiocyanato Bridged Bimetallic Complexes (M-SCN-Co): Synthesis, Characterization and Biological Studies

    Mohammad Nasir Uddin , Tania Sultana Rupa

    Issue: Volume 3, Issue 1-1, January 2015
    Pages: 1-6
    Received: Dec. 18, 2014
    Accepted: Dec. 25, 2014
    Published: Jan. 27, 2015
    DOI: 10.11648/j.mc.s.2015030101.11
    Downloads:
    Views:
    Abstract: A number of bimetallic thiocyanato-bridged complexes of cations [M(NH2X)6]2+ and [M(en)3]2+ with anions [Co(NCS)4]2– are prepared. Their structure has been investigated in terms of FT-IR, 13C NMR and UV-vis spectroscopy, metal analysis, magnetic and conductance studies. The complexes are proposed to have the following compositions, [M(NH2X)5][Co(NC... Show More