Effects of the Extracts of Euphorbia pulcherima and Atriplex nummularia on the Infectivity of Schistosoma haematobium to Bulinus truncatus Snails
Fayez A. Bakry,
Manal El-Garhy,
Mahmoud Abd El-Atti,
Marwa Th. Atwa
Issue:
Volume 1, Issue 2, October 2017
Pages:
34-41
Received:
23 April 2017
Accepted:
8 May 2017
Published:
6 July 2017
DOI:
10.11648/j.abm.20170102.12
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Abstract: Effects of extracts of Euphorbia pulcherima and Atriplex nummularia on infection rate and cercarial production of The Bulinus truncatus infected with Schistosoma haematobium, as well as on the free living stages of the parasite (miracidia and cercariae) besides biochemical parameters of the snail were studied. The results showed that the LC25 of the extracts of E. pulcherima and A. nummularia caused a considerable reduction in the infectivity
Abstract: Effects of extracts of Euphorbia pulcherima and Atriplex nummularia on infection rate and cercarial production of The Bulinus truncatus infected with Schistosoma haematobium, as well as on the free living stages of the parasite (miracidia and cercariae) besides biochemical parameters of the snail were studied. The results showed that the LC25 of th...
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Density Functional Theory (DFT) Based Quantitative Structure Toxicity Relationship (QSTR) Modelling of the Acute Toxicity of Phenols
Ibraheem Wasiu Aderemi,
Ameji Philip John,
Awor George Okorn,
Racheal U. Akpa,
Raji Saheed Akinleye
Issue:
Volume 1, Issue 2, October 2017
Pages:
42-46
Received:
26 April 2017
Accepted:
9 May 2017
Published:
6 July 2017
DOI:
10.11648/j.abm.20170102.13
Downloads:
Views:
Abstract: A toxicity data set of 58 phenols to Tetrahymena pyriformis expressed as pEC50 (Log to base 10 of effective concentration, EC50) was taken from literature and the molecular structure of each molecule was optimized to obtain their minimum energy geometry. The descriptors of each optimized molecule were computed and subsequently used to build QSTR models. The best QSTR model hinted that the toxicity of phenol was dominantly influenced by the descriptors; molecular complexity (FMF), valence path cluster (VPC) and topological diameter (topo). The results of the statistical analysis of the tri- parametric model include; n = 41, Lack of fit (LOF) score = 0.06566, R2 = 0.7629, R2adj.= 0.7437, Q2LOO = 0.7, F-value = 39.69. The generated QSTR model has been proven to possess statistical significance, high predictive power and wide applicability domain. Thus, it is recommended for environmental risk assessment of phenols.
Abstract: A toxicity data set of 58 phenols to Tetrahymena pyriformis expressed as pEC50 (Log to base 10 of effective concentration, EC50) was taken from literature and the molecular structure of each molecule was optimized to obtain their minimum energy geometry. The descriptors of each optimized molecule were computed and subsequently used to build QSTR mo...
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