International Journal of Clinical and Developmental Anatomy

Volume 2, Issue 3, May 2016

  • Effect of Pirfenidone on Bleomycin Induced Pulmonary Alveolar Fibrosis in Adult Male Rats (Histological, Immunohistochemical, Morphometrical and Biochemical Study)

    Ayman M. Mousa

    Issue: Volume 2, Issue 3, May 2016
    Pages: 17-23
    Received: 26 May 2016
    Accepted: 3 June 2016
    Published: 12 June 2016
    DOI: 10.11648/j.ijcda.20160203.11
    Abstract: Introduction: Bleomycin is a chemotherapeutic agent commonly used to treat curable diseases such as Hodgkin’s lymphoma. The major limitation of bleomycin therapy is the pulmonary toxicity. Pirfenidone is a modified phenyl pyridine that has an antioxidant, anti-transforming growth factor and anti-platelet derived growth factor effects. Aim of the st... Show More