Abstract: Background: The prevalence of MIH in modern population is increasing during the last decades. Most of the etiology factors today are based on perinatal health disorders. In order to understand if the hypomineralization of the enamel in MIH/HSPM is a novel developmental disorder, we compared the prevalence of modern population to archeological population with a high rate of mortality of young children. Objectives: To analyze the prevalence of MIH/HSPM in ancient population of Dor, Israel (16th-19th centuries). Materials: We examined 104 skulls out of 157 skeletons excavated, which had at least one permanent and/or one primary second molars for MIH/HSPM. Methods: All skulls were examined under a white light and skulls with MIH/SPMH were photographed. The skulls with suspected MIH/SPMH underwent CT analyses. Results: Three skulls out of the 104 skulls examined showed distinct enamel developmental defects on primary or permanent molars: one with MIH, one with HSPM and one with hypoplasia of second primary molars. Conclusions: Very low percentages of MIH/HSPM were found in Dor population, in comparison with modern prevalence of MIH in Israel, almost 18% of childrens 6-16 years old. Significance: In modern Israeli population with minimal perinatal health problems the prevalence of MIH/HSPM is very high and increasing. Based on the very low prevalence of MIH/HSPM in Dor population and the poor health situation of the children, we can conclude that the proposed aetiology of hypomineralization based on health or developmental problems during early childhood in modern population is questionable. Suggestion for further research: In modern populations the research should be directed to epigenetic factors in affected families.Abstract: Background: The prevalence of MIH in modern population is increasing during the last decades. Most of the etiology factors today are based on perinatal health disorders. In order to understand if the hypomineralization of the enamel in MIH/HSPM is a novel developmental disorder, we compared the prevalence of modern population to archeological popul...Show More