Pyruvic acid (pyruvate plus hydrogen [H+]) is a key of important metabolites in glucose metabolism. Exogenous pyruvate can efficiently improve glucometabolic disorders: mainly preservation of anaerobic glycolysis in cytosol, reactivation of declined oxidative phosphorylation in mitochondria, hence, restoration of the aberrant Warburg effect, enhancement of redox potential status, inhibition of inflammation and apoptosis in addition to depression of advanced glycation end products (AGEs) in tissues. Therefore, pyruvate can protect against diabetes and its organ complications, turning the vicious cycle virtuous in diabetic initiation and development. Pyruvate advantages are incomparable to anions in current medical fluids and hold a potential paramount significance in clinical settings. This review illustrated pyruvate beneficial biomedical properties and their effects on the prevention and treatment of diabetes and diabetic organ complications with the experimental evidence and clinical case reports. It highlights the novel possibility to deal with diabetes by oral pyruvate, the superior choice to resuscitate critical care patients with or without diabetes by pyruvate-enriched fluids and the feasibility to prevent and treat diabetes and its complications with pyruvate-enriched oral rehydration solutions (Pyr-ORS) as a functional beverage in a large population. Attention must be paid to diabetes research with pyruvate and its clinical trials are urgently warranted.
| Published in | Asia-Pacific Journal of Medicine (Volume 3, Issue 3) |
| Page(s) | 14-20 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Pyruvate, Diabetes, Diabetic Organ Complications, Glucose Metabolism, Oral Rehydration Salt
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APA Style
Zhou Fang Qiang. (2020). Pyruvate Potential Effects on the Prevention and Treatment of Diabetes and Its Organ Complications. Asia-Pacific Journal of Medicine, 3(3), 14-20.
ACS Style
Zhou Fang Qiang. Pyruvate Potential Effects on the Prevention and Treatment of Diabetes and Its Organ Complications. Asia-Pac. J. Med. 2020, 3(3), 14-20.
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Download@article{10051999,
author = {Zhou Fang Qiang},
title = {Pyruvate Potential Effects on the Prevention and Treatment of Diabetes and Its Organ Complications},
journal = {Asia-Pacific Journal of Medicine},
volume = {3},
number = {3},
pages = {14-20},
url = {https://www.sciencepublishinggroup.com/article/10051999},
abstract = {Pyruvic acid (pyruvate plus hydrogen [H+]) is a key of important metabolites in glucose metabolism. Exogenous pyruvate can efficiently improve glucometabolic disorders: mainly preservation of anaerobic glycolysis in cytosol, reactivation of declined oxidative phosphorylation in mitochondria, hence, restoration of the aberrant Warburg effect, enhancement of redox potential status, inhibition of inflammation and apoptosis in addition to depression of advanced glycation end products (AGEs) in tissues. Therefore, pyruvate can protect against diabetes and its organ complications, turning the vicious cycle virtuous in diabetic initiation and development. Pyruvate advantages are incomparable to anions in current medical fluids and hold a potential paramount significance in clinical settings. This review illustrated pyruvate beneficial biomedical properties and their effects on the prevention and treatment of diabetes and diabetic organ complications with the experimental evidence and clinical case reports. It highlights the novel possibility to deal with diabetes by oral pyruvate, the superior choice to resuscitate critical care patients with or without diabetes by pyruvate-enriched fluids and the feasibility to prevent and treat diabetes and its complications with pyruvate-enriched oral rehydration solutions (Pyr-ORS) as a functional beverage in a large population. Attention must be paid to diabetes research with pyruvate and its clinical trials are urgently warranted.},
year = {2020}
}
TY - JOUR T1 - Pyruvate Potential Effects on the Prevention and Treatment of Diabetes and Its Organ Complications AU - Zhou Fang Qiang Y1 - 2020/11/30 PY - 2020 T2 - Asia-Pacific Journal of Medicine JF - Asia-Pacific Journal of Medicine JO - Asia-Pacific Journal of Medicine SP - 14 EP - 20 PB - Science Publishing Group UR - http://www.sciencepg.com/article/10051999 AB - Pyruvic acid (pyruvate plus hydrogen [H+]) is a key of important metabolites in glucose metabolism. Exogenous pyruvate can efficiently improve glucometabolic disorders: mainly preservation of anaerobic glycolysis in cytosol, reactivation of declined oxidative phosphorylation in mitochondria, hence, restoration of the aberrant Warburg effect, enhancement of redox potential status, inhibition of inflammation and apoptosis in addition to depression of advanced glycation end products (AGEs) in tissues. Therefore, pyruvate can protect against diabetes and its organ complications, turning the vicious cycle virtuous in diabetic initiation and development. Pyruvate advantages are incomparable to anions in current medical fluids and hold a potential paramount significance in clinical settings. This review illustrated pyruvate beneficial biomedical properties and their effects on the prevention and treatment of diabetes and diabetic organ complications with the experimental evidence and clinical case reports. It highlights the novel possibility to deal with diabetes by oral pyruvate, the superior choice to resuscitate critical care patients with or without diabetes by pyruvate-enriched fluids and the feasibility to prevent and treat diabetes and its complications with pyruvate-enriched oral rehydration solutions (Pyr-ORS) as a functional beverage in a large population. Attention must be paid to diabetes research with pyruvate and its clinical trials are urgently warranted. VL - 3 IS - 3 ER -
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