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Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone

Received: 1 August 2017     Accepted: 16 August 2017     Published: 20 October 2017
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Abstract

Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.

Published in World Journal of Applied Chemistry (Volume 2, Issue 4)
DOI 10.11648/j.wjac.20170204.14
Page(s) 134-139
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Trityl Candesartan, Tin, UV-VIS Spectrophotometer, Phenylflourone

References
[1] T Naka, K Nishikawa, T Kato. Preparation of benzimidazole derivatives as angiotensin II antagonists. Eur. Pat. Appl. (1991); EP 459136 A1 19911204.
[2] A Asati, A Shinde, S Malik, KC Asati. Analytical Assay development on Validation for Estimation of Trityl Candesartan in Bulk Drug of Reverse Phase Liquid Chromatography. Int. J. Pharm. Sci. Rev. Res. 26(1), May-June 2014; Article No. 29, pp. 169-173.
[3] National Center for Biotechnology Information. PubChem Compound Database; CID=10312563. https://pubchem.ncbi.nlm.nih.gov/compound/10312563.
[4] MY Etinger, B Fedotev, B-Z Dolitzky; Preparation of candesartan cilexetil; PCT Int. Appl.; August 2006; US7098342 B2.
[5] B Parthasaradhi, K Rathnakar, R Raji, D Muralidhara, M Ramakrishna. Process for Preparation of Candesartan Cilexitil. Pat. Appl.; April 2011; EP2303870 A2.
[6] Department of Health and Human Services, Public Health Service. Tin and Tin Compounds. Agency for Toxic Substances and Disease Registry. August 2005; p. 4.
[7] P Howe, M Wood, P Watts. Tin and Inorganic Compounds. Concise International Chemical Assessment Document 65. World Health Organization Geneva, 2005; pp. 5-6.
[8] S Dobson, R Cabridenc. Tributyltin Compounds. Environmental Health Criteria 116; International Programme on Chemical Safety; World Health Organization Geneva, 1990; Section 12.
[9] Japanese Pharmacopeia XVI; General Tests; Test Methods for Tin; p.
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  • APA Style

    Yusuf Yildiz, Angela Jan, Lokesh Pendyala, Berrak Yildiz. (2017). Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone. World Journal of Applied Chemistry, 2(4), 134-139. https://doi.org/10.11648/j.wjac.20170204.14

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    ACS Style

    Yusuf Yildiz; Angela Jan; Lokesh Pendyala; Berrak Yildiz. Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone. World J. Appl. Chem. 2017, 2(4), 134-139. doi: 10.11648/j.wjac.20170204.14

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    AMA Style

    Yusuf Yildiz, Angela Jan, Lokesh Pendyala, Berrak Yildiz. Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone. World J Appl Chem. 2017;2(4):134-139. doi: 10.11648/j.wjac.20170204.14

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  • @article{10.11648/j.wjac.20170204.14,
      author = {Yusuf Yildiz and Angela Jan and Lokesh Pendyala and Berrak Yildiz},
      title = {Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone},
      journal = {World Journal of Applied Chemistry},
      volume = {2},
      number = {4},
      pages = {134-139},
      doi = {10.11648/j.wjac.20170204.14},
      url = {https://doi.org/10.11648/j.wjac.20170204.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20170204.14},
      abstract = {Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone
    AU  - Yusuf Yildiz
    AU  - Angela Jan
    AU  - Lokesh Pendyala
    AU  - Berrak Yildiz
    Y1  - 2017/10/20
    PY  - 2017
    N1  - https://doi.org/10.11648/j.wjac.20170204.14
    DO  - 10.11648/j.wjac.20170204.14
    T2  - World Journal of Applied Chemistry
    JF  - World Journal of Applied Chemistry
    JO  - World Journal of Applied Chemistry
    SP  - 134
    EP  - 139
    PB  - Science Publishing Group
    SN  - 2637-5982
    UR  - https://doi.org/10.11648/j.wjac.20170204.14
    AB  - Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Analytical Chemistry, Complete Analysis Laboratories, Highland Park, USA

  • Department of Analytical Research, Eu Tech Scientific Services, Highland Park, USA

  • Department of Biomedical Sciences, Rutgers University, New Brunswick, USA

  • Department of Biomedical Sciences, Rutgers University, New Brunswick, USA

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