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Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea

Received: 10 October 2016     Accepted: 1 November 2016     Published: 23 November 2016
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Abstract

A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.

Published in World Journal of Applied Chemistry (Volume 1, Issue 1)
DOI 10.11648/j.wjac.20160101.14
Page(s) 22-25
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Nickel, Mixed Ligand Complex, Antimicrobial, Furfuralurea, Coordination Compounds

References
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    Idoko Owoicho, Emmanuel Stella, Abubakar Salisu, Thomas Sunday Asuquo. (2016). Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World Journal of Applied Chemistry, 1(1), 22-25. https://doi.org/10.11648/j.wjac.20160101.14

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    ACS Style

    Idoko Owoicho; Emmanuel Stella; Abubakar Salisu; Thomas Sunday Asuquo. Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World J. Appl. Chem. 2016, 1(1), 22-25. doi: 10.11648/j.wjac.20160101.14

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    AMA Style

    Idoko Owoicho, Emmanuel Stella, Abubakar Salisu, Thomas Sunday Asuquo. Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World J Appl Chem. 2016;1(1):22-25. doi: 10.11648/j.wjac.20160101.14

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  • @article{10.11648/j.wjac.20160101.14,
      author = {Idoko Owoicho and Emmanuel Stella and Abubakar Salisu and Thomas Sunday Asuquo},
      title = {Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea},
      journal = {World Journal of Applied Chemistry},
      volume = {1},
      number = {1},
      pages = {22-25},
      doi = {10.11648/j.wjac.20160101.14},
      url = {https://doi.org/10.11648/j.wjac.20160101.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20160101.14},
      abstract = {A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea
    AU  - Idoko Owoicho
    AU  - Emmanuel Stella
    AU  - Abubakar Salisu
    AU  - Thomas Sunday Asuquo
    Y1  - 2016/11/23
    PY  - 2016
    N1  - https://doi.org/10.11648/j.wjac.20160101.14
    DO  - 10.11648/j.wjac.20160101.14
    T2  - World Journal of Applied Chemistry
    JF  - World Journal of Applied Chemistry
    JO  - World Journal of Applied Chemistry
    SP  - 22
    EP  - 25
    PB  - Science Publishing Group
    SN  - 2637-5982
    UR  - https://doi.org/10.11648/j.wjac.20160101.14
    AB  - A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

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