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Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review

Received: 23 December 2015     Accepted: 23 February 2016     Published: 16 April 2016
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Abstract

Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.

Published in Science Journal of Clinical Medicine (Volume 5, Issue 4-1)

This article belongs to the Special Issue Clinical Conspectus on Cleft Deformities

DOI 10.11648/j.sjcm.s.2016050401.12
Page(s) 7-13
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Bone Tissue Engineering, Cleft, Stem Cells, Growth Factors, Scaffolds

References
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  • APA Style

    Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. (2016). Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Science Journal of Clinical Medicine, 5(4-1), 7-13. https://doi.org/10.11648/j.sjcm.s.2016050401.12

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    ACS Style

    Rohit Raghavan; Sumitra S.; Nadeem Abdul Rahman; Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci. J. Clin. Med. 2016, 5(4-1), 7-13. doi: 10.11648/j.sjcm.s.2016050401.12

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    AMA Style

    Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci J Clin Med. 2016;5(4-1):7-13. doi: 10.11648/j.sjcm.s.2016050401.12

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  • @article{10.11648/j.sjcm.s.2016050401.12,
      author = {Rohit Raghavan and Sumitra S. and Nadeem Abdul Rahman and Justin Baby},
      title = {Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review},
      journal = {Science Journal of Clinical Medicine},
      volume = {5},
      number = {4-1},
      pages = {7-13},
      doi = {10.11648/j.sjcm.s.2016050401.12},
      url = {https://doi.org/10.11648/j.sjcm.s.2016050401.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2016050401.12},
      abstract = {Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.},
     year = {2016}
    }
    

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    DO  - 10.11648/j.sjcm.s.2016050401.12
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    AB  - Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.
    VL  - 5
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Author Information
  • Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala

  • Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala

  • Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala

  • Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala

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