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Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis

Received: 10 October 2021     Accepted: 28 October 2021     Published: 5 November 2021
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Abstract

Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.

Published in Science Journal of Clinical Medicine (Volume 10, Issue 4)
DOI 10.11648/j.sjcm.20211004.12
Page(s) 89-96
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Ocular Burn, Amniotic Membrane Transplantation, Complications, Meta-analysis

References
[1] Singh, P., M. Tyagi, Y. Kumar, et al., Ocular chemical injuries and their management. Oman J Ophthalmol, 2013. 6 (2): p. 83-6.
[2] Fish, R. and R. S. Davidson, Management of ocular thermal and chemical injuries, including amniotic membrane therapy. Curr Opin Ophthalmol, 2010. 21 (4): p. 317-21.
[3] Jirsova, K. and G. L. A. Jones, Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting-a review. Cell Tissue Bank, 2017. 18 (2): p. 193-204.
[4] Schallenberg, M., H. Westekemper, K. P. Steuhl, et al., Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. Bmc Ophthalmology, 2013. 13.
[5] Sharma, N., S. S. Lathi, S. V. Sehra, et al., Comparison of umbilical cord serum and amniotic membrane transplantation in acute ocular chemical burns. Br J Ophthalmol, 2015. 99 (5): p. 669-73.
[6] Tamhane, A., R. B. Vajpayee, N. R. Biswas, et al., Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. Ophthalmology, 2005. 112 (11): p. 1963-1969.
[7] Tandon, R., N. Gupta, M. Kalaivani, et al., Amniotic membrane transplantation as an adjunct to medical therapy in acute ocular burns. Br J Ophthalmol, 2011. 95 (2): p. 199-204.
[8] Sharma, N., D. Singh, P. K. Maharana, et al., Comparison of Amniotic Membrane Transplantation and Umbilical Cord Serum in Acute Ocular Chemical Burns: A Randomized Controlled Trial. Am J Ophthalmol, 2016. 168: p. 157-163.
[9] Eslani, M., A. Baradaran-Rafii, A. Y. Cheung, et al., Amniotic Membrane Transplantation in Acute Severe Ocular Chemical Injury: A Randomized Clinical Trial. Am J Ophthalmol, 2019. 199: p. 209-215.
[10] Hao, Y., D. H. -K. Ma, D. G. Hwang, et al., Identification of Antiangiogenic and Antiinflammatory Proteins in Human Amniotic Membrane. Cornea, 2000. 19 (3): p. 348–352.
[11] Davis, J., Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital. Johns Hopkins Med J, 1910. 15: p. 307.
[12] Ro¨tth, A. d., Plastic repair of conjunctival defects with fetal membrane. Arch Ophthalmol, 1940. 23: p. 522–525.
[13] Sorsby, A. and H. M. Symons, Amniotic membrane grafts in caustic burns of the eye (burns of the second degree). Br J Ophthalmol, 1946. 30 (6): p. 337–345.
[14] Fernandes, M., M. S. Sridhar, V. S. Sangwan, et al., Amniotic membrane transplantation for ocular surface reconstruction. Cornea, 2005. 24 (6): p. 643-653.
[15] Sorsby A, Haythorne J, and R. H., Further experience with amniotic membrane grafts in caustic burns of the eye. Br J Ophthalmol, 1947. 31 (7): p. 409 –18.
[16] Meller, D., R. T. Pires, R. J. Mack, et al., Amniotic membrane transplantation for acute chemical orthermal burns. Ophthalmology, 2000. 107 (5): p. 980–989.
[17] Sridhar, M. S., A. K. Bansal, V. S. Sangwan, et al., Amniotic membrane transplantation in acute chemical and thermal injury. Am J Ophthalmol, 2000. 130 (1): p. 134-137.
[18] Joseph., A., H. S. Dua., and A. J. King, Failure of amniotic membrane transplantation in the treatment of acute ocular burns. Br J Ophthalmol, 2001. 85 (9): p. 1065–1069.
[19] Kobayashi, A., Y. Shirao, T. Yoshita, et al., Temporary amniotic membrane patching for acute chemical burns. Eye, 2003. 17 (2): p. 149-158.
[20] Arora, R., D. Mehta, and V. Jain, Amniotic membrane transplantation in acute chemical burns. Eye, 2005. 19 (3): p. 273-278.
[21] Tejwani, S., R. S. Kolari, V. S. Sangwan, et al., Role of amniotic membrane graft for ocular chemical and thermal injuries. Cornea, 2007. 26 (1): p. 21-26.
[22] Kheirkhah, A., D. A. Johnson, D. R. Paranjpe, et al., Temporary sutureless amniotic membrane patch for acute alkaline burns. Arch Ophthalmol, 2008. 126 (8): p. 1059-1066.
[23] Gheorghe, A., M. Pop, M. Burcea, et al., New clinical application of amniotic membrane transplant for ocular surface disease. J Med Life, 2016. 9 (2): p. 177-9.
[24] Westekemper, H., F. C. Figueiredo, W. F. Siah, et al., Clinical outcomes of amniotic membrane transplantation in the management of acute ocular chemical injury. Br J Ophthalmol, 2017. 101 (2): p. 103-107.
[25] López-García, J. S., L. Rivas, I. García-Lozano, et al., Evolution After Moderate Alkaline Burns by Using Impression Cytology. Cornea, 2006. 25 (8): p. 908–913.
[26] Prabhasawat, P., N. Tesavibul, N. Prakairungthong, et al., Efficacy of amniotic membrane patching for acute chemical and thermal ocular burns. J Med Assoc Thai, 2007. 90 (2): p. 319-26.
[27] Walkden, A., Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective. Clin Ophthalmol, 2020. 14: p. 2057-2072.
Cite This Article
  • APA Style

    Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. (2021). Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Science Journal of Clinical Medicine, 10(4), 89-96. https://doi.org/10.11648/j.sjcm.20211004.12

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    ACS Style

    Hua Wang; Jun-Jie Tang; Qing Zhou; Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci. J. Clin. Med. 2021, 10(4), 89-96. doi: 10.11648/j.sjcm.20211004.12

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    AMA Style

    Hua Wang, Jun-Jie Tang, Qing Zhou, Jian Chen. Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis. Sci J Clin Med. 2021;10(4):89-96. doi: 10.11648/j.sjcm.20211004.12

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  • @article{10.11648/j.sjcm.20211004.12,
      author = {Hua Wang and Jun-Jie Tang and Qing Zhou and Jian Chen},
      title = {Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis},
      journal = {Science Journal of Clinical Medicine},
      volume = {10},
      number = {4},
      pages = {89-96},
      doi = {10.11648/j.sjcm.20211004.12},
      url = {https://doi.org/10.11648/j.sjcm.20211004.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211004.12},
      abstract = {Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effects of Amniotic Membrane Transplantation in Ocular Burns: A Meta-Analysis
    AU  - Hua Wang
    AU  - Jun-Jie Tang
    AU  - Qing Zhou
    AU  - Jian Chen
    Y1  - 2021/11/05
    PY  - 2021
    N1  - https://doi.org/10.11648/j.sjcm.20211004.12
    DO  - 10.11648/j.sjcm.20211004.12
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 89
    EP  - 96
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20211004.12
    AB  - Background: Ocular burns is a serious eye injury with a high rate of blindness, efforts should be made to eliminate the serious complications, prevent from lifelong disability, and improve emergency interventions and treatment. Objective: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in ocular burns. Methods: The following electronic databases were searched: PubMed, Web of Science, and Cochrane Library. With the keyword “amniotic membrane” and “ocular burn”. No limitation of year, language, gender, age, nationality, etc. Animal trials, patients with other ocular surface diseases, and amniotic membrane transplantation combined with other surgeries were excluded. We evaluated the corneal epithelium healing time (CEHT), tear break-up time (TBUT), Schirmer test (ST), corneal neovascularization, the formation of symblepharon, and lid abnormalities after conventional treatment (CT) and AMT. The differences were tested by referring to the Cochrane Handbook. Pooled estimates were determined with RevMan software, version 5.3. Results: 5 studies with 310 eyes of 282 participants suffering from ocular burns were included. There was no significant difference between CT and AMT among the following outcomes: CEHT, TBUT, ST, formation of symblepharon, and lid abnormalities, except the extent of corneal neovascularization, which was less in patients treated with AMT (RR 0.81; 95% CI 0.68, 0.96; I2 = 40%, p = 0.02). Conclusions: Compared to CT, AMT does not show better advantages in promoting epithelial healing, improving tear film status, and preventing complications such as symblepharon formation and eyelid abnormalities except reducing corneal neovascularization.
    VL  - 10
    IS  - 4
    ER  - 

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Author Information
  • First School of Clinical Medicine, Jinan University, Guangzhou, China

  • First School of Clinical Medicine, Jinan University, Guangzhou, China

  • Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou, China

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