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Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal

Received: 26 March 2019     Accepted: 6 May 2019     Published: 31 May 2019
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Abstract

Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.

Published in Science Journal of Clinical Medicine (Volume 8, Issue 1)
DOI 10.11648/j.sjcm.20190801.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Radiotherapy, Hyperthermia, Locoregional Recurrence, Reirradiation

References
[1] J Zee, B Holt, PJM Rietveld, et al. Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. British Journal of cancer (1999) 79 (3/4), 483-490.
[2] NG Huilgol, S Gupta, CR Sridhar. Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial. J. Cancer Res. Ther. (2010) 6 (4), 492-496.
[3] M Mallory, E Gogineni, GC Jones, et al. Therapeutic hyperthermia: The old, the new, and the upcoming. Criticals Reviews in Oncology/Hematology 97 (2016), 56-64.
[4] CA Perez, B Gillespie, T Pajak, et al. Quality assurance problems in clinical hyperthermia and their impact on therapeutic outcome: a Report by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys (1989) 16(3), 551-8.
[5] International Collaborative Hyperthermia Group. Hyperthermia in the treatment of superficial localized primary and recurrent breast cancer – results from five randomized controlled trials. Int J Radiat Oncol Biol Phys (1996) 35, 731-744.
[6] H Sahinbas. Retrospective clinical study for advanced brain gliomas by adjuvant electro-hyperthermia treatment. Cancer Therapy (2012) 8, 139-149.
[7] HP Kok, J Crezee. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int J hyperthermia (2017) 33(4), 378-386.
[8] NR Datta, S Rogers, SG Ordóñez, et al. Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis. Int J Hyperthermia (2016) 32(1), 31-40.
[9] NR Datta, E Puric, D Klingbiel, et al. Hyperthermia and radiotherapy in locoregional recurrent breast cancers: A systematic review and meta-analysis. Int J Radiat Oncol Biol Phys (2016) 94(5), 1073-87.
[10] NR Datta, SG Ordóñez, US Gaipl, et al. Local hyperthermia combined with radiotherapy and/or chemotherapy: recent advances and promises for the future. Cancer Treat Rev (2015) 41(9), 742-53.
[11] NR Datta, E Puric, D Klingbiel, et al. Hyperthermia and radiation therapy in locoregional recurrent breast cancers: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys (2016) 94(5):1073–87.
[12] NR Datta, S Rogers, D Klingbiel, et al. Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: a systematic review with conventional and network meta-analyses. Int J Hyperthermia (2016) 6736:1–34.
[13] LCHW Lutgens, PCM Koper, JJ Jobsen, et al. Radiation therapy combined with hyperthermia versus cisplatin for locally advanced cervical cancer: results of the randomized RADCHOC trial. Radiother Oncol (2016) 120(3):378–82.
[14] NR Datta, S Rogers, SG Ordonez, et al S. Hyperthermia and radiotherapy in the management of head and neck cancers: a systematic review and meta-analysis. Int J Hyperthermia (2016) 32(1):31–40.
[15] C Zhao, J Chen, B Yu, et al. Improvement in quality of life in patients with nasopharyngeal carcinoma treated with non-invasive extracorporeal radiofrequency in combination with chemoradiotherapy. Int J Radiat Biol (2014) 90(10):853–8.
[16] M Kang, WQ Liu, YT Qin, et al. Long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treatment of nasopharyngeal carcinoma with cervical lymph node metastases. Asian Pac J Cancer Prev (2013) 14(12):7395–400.
[17] Linthorst M, Baaijens M, Wiggenraad R, et al. Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients. Radiotherapy and Oncology (2015) 117: 217-222.
[18] Peeken JC, Vaupel P, Combs SE. Integrating hyperthermia into modern radiation oncology: what evidence is necessary? Frontiers in Oncology (2017) 7(132): 1-12.
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  • APA Style

    Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. (2019). Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Science Journal of Clinical Medicine, 8(1), 1-5. https://doi.org/10.11648/j.sjcm.20190801.11

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    ACS Style

    Maria Adelina Costa; Carlos Fardilha; Graça Fonseca; Joao Conde; Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci. J. Clin. Med. 2019, 8(1), 1-5. doi: 10.11648/j.sjcm.20190801.11

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    AMA Style

    Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci J Clin Med. 2019;8(1):1-5. doi: 10.11648/j.sjcm.20190801.11

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  • @article{10.11648/j.sjcm.20190801.11,
      author = {Maria Adelina Costa and Carlos Fardilha and Graça Fonseca and Joao Conde and Carmen Calcada and Fatima Rodrigues and Paula Genesio and Fernanda Ponte and Joana Vale and Guilherme Campos and Carla Seixas and Andre Ferreira and Carla Sousa and Moreira Pinto and Paulo Costa},
      title = {Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal},
      journal = {Science Journal of Clinical Medicine},
      volume = {8},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.sjcm.20190801.11},
      url = {https://doi.org/10.11648/j.sjcm.20190801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190801.11},
      abstract = {Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal
    AU  - Maria Adelina Costa
    AU  - Carlos Fardilha
    AU  - Graça Fonseca
    AU  - Joao Conde
    AU  - Carmen Calcada
    AU  - Fatima Rodrigues
    AU  - Paula Genesio
    AU  - Fernanda Ponte
    AU  - Joana Vale
    AU  - Guilherme Campos
    AU  - Carla Seixas
    AU  - Andre Ferreira
    AU  - Carla Sousa
    AU  - Moreira Pinto
    AU  - Paulo Costa
    Y1  - 2019/05/31
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjcm.20190801.11
    DO  - 10.11648/j.sjcm.20190801.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20190801.11
    AB  - Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.
    VL  - 8
    IS  - 1
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Author Information
  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

  • Medical Oncology Service, Hospital CUF, Porto, Portugal

  • Medical Oncology Service, Hospital CUF, Porto, Portugal

  • Medical Oncology Service, Hospital CUF, Porto, Portugal

  • Medical Oncology Service, Hospital CUF, Porto, Portugal

  • Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

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