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HPMC Capsules for Moisture Sensitive and Hygroscopic Products

Received: 21 July 2021     Accepted: 24 August 2021     Published: 30 September 2021
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Abstract

Background: Moisture content varies in capsules made from different materials. Gelatin capsules contain 13-16% moisture. HPMC (Hydroxypropyl methyl cellulose or Hypromellose) capsules may contain moisture 2- 8%. Usual HPMC capsules have inherently low moisture content which allows for the encapsulation of ingredients that are sensitive to moisture and are hygroscopic in nature. This has greatly broadened the scope of capsules in drug delivery. Moisture content of HPMC capsules can be reduced as low as 2%. HPMC capsules lower moisture content is better for moisture sensitive and hygroscopic products. Objective: Low moisture content of HPMC capsules help to improve stability of moisture sensitive active pharmaceutical and active nutraceutical active ingredients. This is illustrated with examples. Different properties of HPMC capsules helps targeted delivery. It offers some special advantages for nutraceutical products. It also helps to improve physical stability of capsules. Liquid filled hard capsules provide many options and are commonly used for nutraceutical products.

Published in Pharmaceutical Science and Technology (Volume 5, Issue 2)
DOI 10.11648/j.pst.20210502.14
Page(s) 50-52
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

HPMC Capsules, Moisture Sensitive Products, Hygroscopic Products, Liquid-filled Hard Capsules

References
[1] Powale Sanjay, Solanki Anita, Almeida Dorene (2020) Formulation flexibility with new era HPMC capsules. https://ondrugdelivery.com/wp-content/uploads/2020/07/109_Jul_2020_ACG.pdf, 63-66.
[2] Majee, S. B., Avlani D., and Biswas G R.(2017). HPMC as capsule shell material: Physicochemical, Pharamceutical and Biopharmaceutical Properties. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 10, pp. 1-6.
[3] Ding, L, Brunaugh A. D. Stegemann S, Jermain S. V., Herpin M J, Kalapath J, Smyth H. D. C. A [2021]. Quality by Design Framework for Capsule- based dry powder inhalers. Pharmaceutitics, 13, 2013.
[4] Powale Sanjay, Diez Fernando, Kalafat Justin & Bhat Jnanadeva Bhat (2018) Suitability of HPMC capsules for pharmaceutical applications. https://www.acg-world.com/sites/default/files/s3/public/whitepapers/HPMC_Pharma_Whitepaper-CC_28.3.18.pdf.
[5] Seufert Ken, Vatsa Kirti (2016) HPMC capsules gain credibility as alternative to gelatin. https://www.tabletscapsules.com/enews_tc/2016/issues/tcnews_12_26_16.html.
[6] Powale Sanjay, Diez Fernando, Kalafat Justin & Bhat Jnanadeva Bhat (2018) HMPC Capsules gaining strong momentum in Nutraceutical Industry. https://www.nutraceuticalbusinessreview.com/news/article_page/HPMC_capsules_gaining_momentum_in_the_nutraceutical_industry_part_I/148123.
[7] Majee SB, Avlani D, Biswas GR (2017) HPMC as capsule shell material: physicochemical, pharmaceutical and biopharmaceutical properties. International Journal Pharmaceutical Sciences. 9 (10): 1-6.
[8] Rodríguez M, Urbano HC, Ríos DM, Lara-Villoslada F, Martínez MAR & Hernández MEM (2016) Evaluation of Viability of Lactobacillus fermentum CECT 5716 in Gelatin and Gastroresistant Capsules. Journal Pharmacy and Pharmacology. 4: 413-418.
[9] https://www.vantage-nutrition.com/liquid-filled-hard-capsules
[10] Maowia M Al-Tabakha. (2010). HPMC Capsules Current status and Future. J Pharm Pharmaceutical Sc 13 (3), 428-442.
Cite This Article
  • APA Style

    Milind Biyani. (2021). HPMC Capsules for Moisture Sensitive and Hygroscopic Products. Pharmaceutical Science and Technology, 5(2), 50-52. https://doi.org/10.11648/j.pst.20210502.14

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    ACS Style

    Milind Biyani. HPMC Capsules for Moisture Sensitive and Hygroscopic Products. Pharm. Sci. Technol. 2021, 5(2), 50-52. doi: 10.11648/j.pst.20210502.14

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    AMA Style

    Milind Biyani. HPMC Capsules for Moisture Sensitive and Hygroscopic Products. Pharm Sci Technol. 2021;5(2):50-52. doi: 10.11648/j.pst.20210502.14

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  • @article{10.11648/j.pst.20210502.14,
      author = {Milind Biyani},
      title = {HPMC Capsules for Moisture Sensitive and Hygroscopic Products},
      journal = {Pharmaceutical Science and Technology},
      volume = {5},
      number = {2},
      pages = {50-52},
      doi = {10.11648/j.pst.20210502.14},
      url = {https://doi.org/10.11648/j.pst.20210502.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20210502.14},
      abstract = {Background: Moisture content varies in capsules made from different materials. Gelatin capsules contain 13-16% moisture. HPMC (Hydroxypropyl methyl cellulose or Hypromellose) capsules may contain moisture 2- 8%. Usual HPMC capsules have inherently low moisture content which allows for the encapsulation of ingredients that are sensitive to moisture and are hygroscopic in nature. This has greatly broadened the scope of capsules in drug delivery. Moisture content of HPMC capsules can be reduced as low as 2%. HPMC capsules lower moisture content is better for moisture sensitive and hygroscopic products. Objective: Low moisture content of HPMC capsules help to improve stability of moisture sensitive active pharmaceutical and active nutraceutical active ingredients. This is illustrated with examples. Different properties of HPMC capsules helps targeted delivery. It offers some special advantages for nutraceutical products. It also helps to improve physical stability of capsules. Liquid filled hard capsules provide many options and are commonly used for nutraceutical products.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - HPMC Capsules for Moisture Sensitive and Hygroscopic Products
    AU  - Milind Biyani
    Y1  - 2021/09/30
    PY  - 2021
    N1  - https://doi.org/10.11648/j.pst.20210502.14
    DO  - 10.11648/j.pst.20210502.14
    T2  - Pharmaceutical Science and Technology
    JF  - Pharmaceutical Science and Technology
    JO  - Pharmaceutical Science and Technology
    SP  - 50
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2640-4540
    UR  - https://doi.org/10.11648/j.pst.20210502.14
    AB  - Background: Moisture content varies in capsules made from different materials. Gelatin capsules contain 13-16% moisture. HPMC (Hydroxypropyl methyl cellulose or Hypromellose) capsules may contain moisture 2- 8%. Usual HPMC capsules have inherently low moisture content which allows for the encapsulation of ingredients that are sensitive to moisture and are hygroscopic in nature. This has greatly broadened the scope of capsules in drug delivery. Moisture content of HPMC capsules can be reduced as low as 2%. HPMC capsules lower moisture content is better for moisture sensitive and hygroscopic products. Objective: Low moisture content of HPMC capsules help to improve stability of moisture sensitive active pharmaceutical and active nutraceutical active ingredients. This is illustrated with examples. Different properties of HPMC capsules helps targeted delivery. It offers some special advantages for nutraceutical products. It also helps to improve physical stability of capsules. Liquid filled hard capsules provide many options and are commonly used for nutraceutical products.
    VL  - 5
    IS  - 2
    ER  - 

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Author Information
  • R&D Consultant, Aspire Advisors Pvt. Ltd., Mumbai, India

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