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Elevated Liver Enzymes in Patients with Cholecystitis

Received: 9 May 2014     Accepted: 15 May 2014     Published: 30 May 2014
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Abstract

Aims: To investigate changes in liver function tests in calcular cholecystitis (acute and chronic) and to relate that changes to cholecystitis. Methods: A retrospective study including 389 patients with clinical and sonographic evidence of cholecystitis with exclusion of other causes of elevated liver function tests, which are done preoperatively and four weeks postoperatively. Results: Increased liver function tests observed in both acute and chronic cholecystitis. The only significant differences between both groups were a higher bilirubin level (P= 0.001) and WBC (P= 0.018). Pre and post-cholecystectomy levels of AST, ALK-P and GGT were significantly changed (P= 0.001). Conclusion: Our study showed that the abnormal biochemical liver function tests resolved rapidly and spontaneously after cholecystectomy indicating transient hepatocellular injury with cholecystitis.

Published in Journal of Surgery (Volume 2, Issue 3)
DOI 10.11648/j.js.20140203.11
Page(s) 38-41
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Cholecystitis, Liver function tests, Leucocytosis

References
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Cite This Article
  • APA Style

    Amir A. Fikry, Arafat A. Kassem, Doaa Shahin, Hosam aldeen S. Shabana. (2014). Elevated Liver Enzymes in Patients with Cholecystitis. Journal of Surgery, 2(3), 38-41. https://doi.org/10.11648/j.js.20140203.11

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    ACS Style

    Amir A. Fikry; Arafat A. Kassem; Doaa Shahin; Hosam aldeen S. Shabana. Elevated Liver Enzymes in Patients with Cholecystitis. J. Surg. 2014, 2(3), 38-41. doi: 10.11648/j.js.20140203.11

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    AMA Style

    Amir A. Fikry, Arafat A. Kassem, Doaa Shahin, Hosam aldeen S. Shabana. Elevated Liver Enzymes in Patients with Cholecystitis. J Surg. 2014;2(3):38-41. doi: 10.11648/j.js.20140203.11

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  • @article{10.11648/j.js.20140203.11,
      author = {Amir A. Fikry and Arafat A. Kassem and Doaa Shahin and Hosam aldeen S. Shabana},
      title = {Elevated Liver Enzymes in Patients with Cholecystitis},
      journal = {Journal of Surgery},
      volume = {2},
      number = {3},
      pages = {38-41},
      doi = {10.11648/j.js.20140203.11},
      url = {https://doi.org/10.11648/j.js.20140203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20140203.11},
      abstract = {Aims: To investigate changes in liver function tests in calcular cholecystitis (acute and chronic) and to relate that changes to cholecystitis. Methods: A retrospective study including 389 patients with clinical and sonographic evidence of cholecystitis with exclusion of other causes of elevated liver function tests, which are done preoperatively and four weeks postoperatively. Results: Increased liver function tests observed in both acute and chronic cholecystitis. The only significant differences between both groups were a higher bilirubin level (P= 0.001) and WBC (P= 0.018). Pre and post-cholecystectomy levels of AST, ALK-P and GGT were significantly changed (P= 0.001). Conclusion: Our study showed that the abnormal biochemical liver function tests resolved rapidly and spontaneously after cholecystectomy indicating transient hepatocellular injury with cholecystitis.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Elevated Liver Enzymes in Patients with Cholecystitis
    AU  - Amir A. Fikry
    AU  - Arafat A. Kassem
    AU  - Doaa Shahin
    AU  - Hosam aldeen S. Shabana
    Y1  - 2014/05/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.js.20140203.11
    DO  - 10.11648/j.js.20140203.11
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 38
    EP  - 41
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20140203.11
    AB  - Aims: To investigate changes in liver function tests in calcular cholecystitis (acute and chronic) and to relate that changes to cholecystitis. Methods: A retrospective study including 389 patients with clinical and sonographic evidence of cholecystitis with exclusion of other causes of elevated liver function tests, which are done preoperatively and four weeks postoperatively. Results: Increased liver function tests observed in both acute and chronic cholecystitis. The only significant differences between both groups were a higher bilirubin level (P= 0.001) and WBC (P= 0.018). Pre and post-cholecystectomy levels of AST, ALK-P and GGT were significantly changed (P= 0.001). Conclusion: Our study showed that the abnormal biochemical liver function tests resolved rapidly and spontaneously after cholecystectomy indicating transient hepatocellular injury with cholecystitis.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

  • Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

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