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Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E

Received: 1 May 2019     Accepted: 21 October 2019     Published: 31 October 2019
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Abstract

Hepatitis E is fairly common among pregnant population and puts a threat to mother and fetal wellbeing. Only limited research is available on association of Hepatitis E infection in pregnancy with feto-maternal outcome. The purpose of the current study was to investigate such patients while carefully eliminating bias by controlling confounders. We aimed to determine the feto-maternal outcome in pregnant women with acute hepatitis E. A descriptive case series was conducted to find feto-maternal outcome in pregnant women with acute hepatitis E. The mean maternal age was 30.05±4.49 years ad mean Gestational age of the patients was 35.73±2.10 months. Most (47%) of the patients were para 3 followed by para 2 (31.8%). 78.8% of the mothers underwent caesarean delivery. Most of the patients had Preterm delivery (69.7%). 16 (24.2%) patients died while majority (75.8%) of the patients survived for more than 30 days after delivery. Most of the mothers (50.0%) died during first 10 days of delivery. 28.8% of patients suffered fetal loss while majority (71.2%) of the neonates survived for more than 7 days. Majority (78.9%) of those who expired died in utero while only a smaller percentage (21.1%) expired in neonatal period. Hepatitis E infection in pregnancy is associated with poor feto-maternal outcome. Careful monitoring and early intervention in the form of caesarean delivery can improve the outcome.

Published in Journal of Gynecology and Obstetrics (Volume 7, Issue 6)
DOI 10.11648/j.jgo.20190706.13
Page(s) 166-169
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Viral Hepatitis, Hepatitis E, Feto-Maternal Outcome

References
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[2] Ahmed W, Qureshi H, Arif A, Alam SE. Changing trend of viral hepatitis—"A twenty one year report from Pakistan Medical Research Council Research Centre, Jinnah Postgraduate Medical Centre, Karachi". JPMA The Journal of the Pakistan Medical Association 2010; 60 (2): 86.
[3] Kasper L, Fauci J. Actue viral hepatitis Havrison’s princ intern Med. 2015; 2 (18) 2537-2555.
[4] Lindeman ML, Gabilondo G, Romero B, et al. low prevalence of hepatitis and infection among pregnant women in Madrid spain J Med Virol. 2010; 82: 1666-1668 doi: 10.1002/jmv.201840.
[5] Purcell R, Emerson S. Hepatitis E: an emerging awareness of an old disease. Journal of hepatology 2008; 48 (3): 494-503.
[6] Alvi AH, Sabir O, IKram –ul-Haq R, Nawaz AA, Riaz: Acute hepatitits E during pregnancy; maternal and fetal Outcome professional Med. J 2015; 22 (11): 1379-1382 DoI: 10.17957/TPMJ /152748.
[7] Navaneethan U, Al Mohajer M, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver international 2008; 28 (9): 1190-9.
[8] Rerou C, goket, locher C, moumenA T, timbely O, savany J. Prospective study of hepatis E virus infection among pregnant women in france. virol J 2014; 11: 11-68.
[9] Borkaoti J, Hazam R J, MOhamad A, kumar A, kar P. Does high viral load of Hepatis E virus infuse the severisity and prognosis of acute level faiure during pregnancy. J Med virol. 2013 april; 85 (4); 620-6. doi: 10.1002/jmv23508. Epub 2012 Dec 26.
[10] Shrestha NS, Shrestha SK, Singh A, Malla K, Thapa LB. Maternal and perinatal outcome of pregnancy with hepatitis E infection. Journal of South Asian Federation of Obstetrics and Gynecology 2011; 3 (1): 17-20.
[11] Mansoor M, Raza H, Tariq R. Feto-maternal outcome in HEV infection. Annals of King Edward Medical University 2011; 17 (1): 86-90.
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[14] Kose V, Joshi S. Pregnancy Outcome in Viral Hepatitis. Journal of South Asian Federation of Obstetrics and Gynaecology 2013; 5 (2): 60-3.
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[16] Yasmeen T, Hashmi HA, Taj A. Fetomaternal outcome with hepatitis e in pregnancy. J Coll Physicians Surg Pak 2013; 23 (10): 711-4.
Cite This Article
  • APA Style

    Sadia Asghar, Sadia Maqbool. (2019). Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E. Journal of Gynecology and Obstetrics, 7(6), 166-169. https://doi.org/10.11648/j.jgo.20190706.13

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    ACS Style

    Sadia Asghar; Sadia Maqbool. Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E. J. Gynecol. Obstet. 2019, 7(6), 166-169. doi: 10.11648/j.jgo.20190706.13

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    AMA Style

    Sadia Asghar, Sadia Maqbool. Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E. J Gynecol Obstet. 2019;7(6):166-169. doi: 10.11648/j.jgo.20190706.13

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  • @article{10.11648/j.jgo.20190706.13,
      author = {Sadia Asghar and Sadia Maqbool},
      title = {Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {7},
      number = {6},
      pages = {166-169},
      doi = {10.11648/j.jgo.20190706.13},
      url = {https://doi.org/10.11648/j.jgo.20190706.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190706.13},
      abstract = {Hepatitis E is fairly common among pregnant population and puts a threat to mother and fetal wellbeing. Only limited research is available on association of Hepatitis E infection in pregnancy with feto-maternal outcome. The purpose of the current study was to investigate such patients while carefully eliminating bias by controlling confounders. We aimed to determine the feto-maternal outcome in pregnant women with acute hepatitis E. A descriptive case series was conducted to find feto-maternal outcome in pregnant women with acute hepatitis E. The mean maternal age was 30.05±4.49 years ad mean Gestational age of the patients was 35.73±2.10 months. Most (47%) of the patients were para 3 followed by para 2 (31.8%). 78.8% of the mothers underwent caesarean delivery. Most of the patients had Preterm delivery (69.7%). 16 (24.2%) patients died while majority (75.8%) of the patients survived for more than 30 days after delivery. Most of the mothers (50.0%) died during first 10 days of delivery. 28.8% of patients suffered fetal loss while majority (71.2%) of the neonates survived for more than 7 days. Majority (78.9%) of those who expired died in utero while only a smaller percentage (21.1%) expired in neonatal period. Hepatitis E infection in pregnancy is associated with poor feto-maternal outcome. Careful monitoring and early intervention in the form of caesarean delivery can improve the outcome.},
     year = {2019}
    }
    

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    T1  - Fetomaternal Outcome in Pregnant Women with Acute Hepatitis E
    AU  - Sadia Asghar
    AU  - Sadia Maqbool
    Y1  - 2019/10/31
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    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
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    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20190706.13
    AB  - Hepatitis E is fairly common among pregnant population and puts a threat to mother and fetal wellbeing. Only limited research is available on association of Hepatitis E infection in pregnancy with feto-maternal outcome. The purpose of the current study was to investigate such patients while carefully eliminating bias by controlling confounders. We aimed to determine the feto-maternal outcome in pregnant women with acute hepatitis E. A descriptive case series was conducted to find feto-maternal outcome in pregnant women with acute hepatitis E. The mean maternal age was 30.05±4.49 years ad mean Gestational age of the patients was 35.73±2.10 months. Most (47%) of the patients were para 3 followed by para 2 (31.8%). 78.8% of the mothers underwent caesarean delivery. Most of the patients had Preterm delivery (69.7%). 16 (24.2%) patients died while majority (75.8%) of the patients survived for more than 30 days after delivery. Most of the mothers (50.0%) died during first 10 days of delivery. 28.8% of patients suffered fetal loss while majority (71.2%) of the neonates survived for more than 7 days. Majority (78.9%) of those who expired died in utero while only a smaller percentage (21.1%) expired in neonatal period. Hepatitis E infection in pregnancy is associated with poor feto-maternal outcome. Careful monitoring and early intervention in the form of caesarean delivery can improve the outcome.
    VL  - 7
    IS  - 6
    ER  - 

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Author Information
  • Department of Obstetrics and Gynecology, Rai Medical College, Sargodha, Pakistan

  • Department of Obstetrics and Gynecology, Ganga Ram Hospital, Lahore, Pakistan

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