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Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis

Received: 15 July 2014     Accepted: 23 July 2014     Published: 30 July 2014
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Abstract

Objective: To compare the rate of preterm delivery in patients who had an amniocentesis before and after 20 weeks gestation. Study Design: This is a single-center retrospective cohort study of patients referred for specialized sonogram between January 1, 2007 and December 31, 2009. Outcomes of patients who underwent amniocentesis at less than 20 0/7 weeks were compared to those who had amniocentesis on or after 20 0/7 weeks. Results: 1041 patients met the inclusion criteria, and 290 (27.9%) underwent amniocentesis. Women were younger in the late amniocentesis group and were more likely to be African-American. Gestational age at delivery, rate of preterm birth,, and birth weight did not differ between the two groups. In a multivariate analysis, gestational age at amniocentesis was not a significant factor for gestational age at delivery. Conclusion: Amniocentesis performed after 20 weeks gestation appears to be safe. This study provides reassuring information regarding late amniocentesis.

Published in Journal of Gynecology and Obstetrics (Volume 2, Issue 4)
DOI 10.11648/j.jgo.20140204.13
Page(s) 59-62
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Amniocentesis, Preterm Delivery, Prenatal Diagnosis

References
[1] Invasive prenatal testing for aneuploidy. ACOG Practice Bulletin No. 88. Obstet Gynecol 2007; 110:1459-1467
[2] Chorionic villus sampling and amniocentesis: recommendations for prenatal counseling. MMWR Recomm Rep 1995;44(RR-9):1-12
[3] Odibo AO, Gray DL, Dicke JM, Stamilio DM, Macones GA, Crane JP. Revisiting the fetal loss rate after second-trimester genetic amniocentesis: a single center’s 16-year experience. Obstet Gynecol 2008; 111:589-95
[4] Mazza V, Pati M, Bertucci E, et al. Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases. Prenat Diagn 2007; 27:180-183
[5] Towner D, Currier RJ, Lorey FW, Cunningham GC, Greve LC.. Miscarriage risk from amniocentesis performed for abnormal maternal serum screening. Am J Obstet Gynecol 2007;196:608.e1-608.e5
[6] Kong CW, Leung TN, Leung TY, et al. Risk factors for procedure-related fetal loses after mid-trimester genetic amniocentesis. Prenat Diagn 2006;26: 925-930
[7] Roper EC, Konje JC, De Chazal RC, Duckett DP, Oppenheimer CA, Taylor DJ. Genetic amniocentesis: gestation-specific pregnancy outcome and comparison of outcome following early and traditional amniocentesis. Prenat Diagn 1999;19: 803-807
[8] Tabor A, Philip J, Madsen M, Bang J, Obel EB, Norgaard-Pedersen B. Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet 1986; 1(8493):1287-1293
[9] Seeds JW. Diagnostic mid trimester amniocentesis: how safe? Am J Obstet Gynecol 2004; 191: 607-615
[10] Mujezinovic F, Alfirevic Z. Procedure-related complications of amniocentesis and chorionic villous sampling: a systematic review. Obstet Gynecol 2007;110: 687-694
[11] Eddleman KA, Malone FD, Sullivan L, et al. Pregnancy loss rates after midtrimester amniocentesis. Obstet Gynecol 2006; 108: 1067-1072
[12] Gordon MC, Narula K, O’Shaughnessy R, Barth WH Jr. Complications of third-trimester amniocentesis using continuous ultrasound guidance. Obstet Gynecol 2002; 99: 255-259
[13] O’Donoghue K, Giorgi L, Pontello V, Pasquini L, Kumar S. Amniocentesis in the third trimester of pregnancy. Prenat Diagn 2007; 27: 1000-1004
[14] Stark CM, Smith RS, Lagrandeur RM,Batton DG, Lorenz RP. Need for urgent delivery after third-trimester amniocentesis. Obstet Gynecol 2000; 95: 48-50
Cite This Article
  • APA Style

    Shauna F. Williams, Emily Fay, Cristina Montalvo, Bart Holland, Joseph J. Apuzzio. (2014). Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis. Journal of Gynecology and Obstetrics, 2(4), 59-62. https://doi.org/10.11648/j.jgo.20140204.13

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    ACS Style

    Shauna F. Williams; Emily Fay; Cristina Montalvo; Bart Holland; Joseph J. Apuzzio. Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis. J. Gynecol. Obstet. 2014, 2(4), 59-62. doi: 10.11648/j.jgo.20140204.13

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    AMA Style

    Shauna F. Williams, Emily Fay, Cristina Montalvo, Bart Holland, Joseph J. Apuzzio. Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis. J Gynecol Obstet. 2014;2(4):59-62. doi: 10.11648/j.jgo.20140204.13

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  • @article{10.11648/j.jgo.20140204.13,
      author = {Shauna F. Williams and Emily Fay and Cristina Montalvo and Bart Holland and Joseph J. Apuzzio},
      title = {Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {2},
      number = {4},
      pages = {59-62},
      doi = {10.11648/j.jgo.20140204.13},
      url = {https://doi.org/10.11648/j.jgo.20140204.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20140204.13},
      abstract = {Objective: To compare the rate of preterm delivery in patients who had an amniocentesis before and after 20 weeks gestation. Study Design: This is a single-center retrospective cohort study of patients referred for specialized sonogram between January 1, 2007 and December 31, 2009. Outcomes of patients who underwent amniocentesis at less than 20 0/7 weeks were compared to those who had amniocentesis on or after 20 0/7 weeks. Results: 1041 patients met the inclusion criteria, and 290 (27.9%) underwent amniocentesis. Women were younger in the late amniocentesis group and were more likely to be African-American. Gestational age at delivery, rate of preterm birth,, and birth weight did not differ between the two groups. In a multivariate analysis, gestational age at amniocentesis was not a significant factor for gestational age at delivery. Conclusion: Amniocentesis performed after 20 weeks gestation appears to be safe. This study provides reassuring information regarding late amniocentesis.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Pregnancy Outcomes after Late Second Trimester Amniocentesis for Prenatal Diagnosis
    AU  - Shauna F. Williams
    AU  - Emily Fay
    AU  - Cristina Montalvo
    AU  - Bart Holland
    AU  - Joseph J. Apuzzio
    Y1  - 2014/07/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.jgo.20140204.13
    DO  - 10.11648/j.jgo.20140204.13
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 59
    EP  - 62
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20140204.13
    AB  - Objective: To compare the rate of preterm delivery in patients who had an amniocentesis before and after 20 weeks gestation. Study Design: This is a single-center retrospective cohort study of patients referred for specialized sonogram between January 1, 2007 and December 31, 2009. Outcomes of patients who underwent amniocentesis at less than 20 0/7 weeks were compared to those who had amniocentesis on or after 20 0/7 weeks. Results: 1041 patients met the inclusion criteria, and 290 (27.9%) underwent amniocentesis. Women were younger in the late amniocentesis group and were more likely to be African-American. Gestational age at delivery, rate of preterm birth,, and birth weight did not differ between the two groups. In a multivariate analysis, gestational age at amniocentesis was not a significant factor for gestational age at delivery. Conclusion: Amniocentesis performed after 20 weeks gestation appears to be safe. This study provides reassuring information regarding late amniocentesis.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Obstetrics, Gynecology and Women’s Health, Division of Maternal Fetal Medicine, Newark, New Jersey

  • Department of Obstetrics, Gynecology and Women’s Health, Division of Maternal Fetal Medicine, Newark, New Jersey

  • Department of Obstetrics, Gynecology and Women’s Health, Division of Maternal Fetal Medicine, Newark, New Jersey

  • Department of Preventive Medicine and Community Health, Rutgers New Jersey Medical School, Newark, New Jersey

  • Department of Obstetrics, Gynecology and Women’s Health, Division of Maternal Fetal Medicine, Newark, New Jersey

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