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Lion’s Mane for Your Brain and Body

Received: 18 February 2025     Accepted: 6 March 2025     Published: 21 March 2025
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Abstract

Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health.

Published in Journal of Food and Nutrition Sciences (Volume 13, Issue 2)
DOI 10.11648/j.jfns.20251302.14
Page(s) 85-92
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Lion’s Mane Mushroom, Hericium erinaceus, Distinguishing Features, Edibility, Supplements, Improving Brain Function, Easing Depression and Anxiety, Heart Health, Diabetes Management

References
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[2] Černelič Bizjak, M., Jenko Pražnikar, Z., Kenig, S., Hladnik, M., Bandelj, D., Gregori, A., & Kranjc, K. (2024). Effect of erinacine A-enriched Hericium erinaceus supplementation on cognition: A randomized, double-blind, placebo-controlled pilot study. Journal of Functional Foods, 115, 106120.
[3] Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27; 23(1): 49.
[4] Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci. 2016 Nov 1; 17(11): 1810.
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[8] Docherty S, Doughty FL, Smith EF. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023 Nov 20; 15(22): 4842.
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[10] Ren Z, Qin T, Qiu F, Song Y, Lin D, Ma Y, Li J, Huang Y. Immunomodulatory effects of hydroxyethylated Hericium erinaceus polysaccharide on macrophages RAW264.7. Int J Biol Macromol. 2017 Dec; 105.
[11] Diling C, Chaoqun Z, Jian Y, Jian L, Jiyan S, Yizhen X, Guoxiao L. Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota. Front Immunol. 2017 Jun 12; 8: 666.
[12] Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012 Jun 6; 60(22): 5590-6.
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[16] Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed Res Int. 2014; 2014: 828149.
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[20] Zhang C, Li J, Hu C, Wang J, Zhang J, Ren Z, Song X, Jia L. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. Sci Rep. 2017 Sep 7; 7(1): 10847
[21] Lee SK, Ryu SH, Turk A, Yeon SW, Jo YH, Han YK, Hwang BY, Lee KY, Lee MK. Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus). J Ethnopharmacol. 2020 Nov 15; 262: 113197.
[22] Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. 2015; 2015: 595480
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  • APA Style

    Amaranthus, M. (2025). Lion’s Mane for Your Brain and Body. Journal of Food and Nutrition Sciences, 13(2), 85-92. https://doi.org/10.11648/j.jfns.20251302.14

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    ACS Style

    Amaranthus, M. Lion’s Mane for Your Brain and Body. J. Food Nutr. Sci. 2025, 13(2), 85-92. doi: 10.11648/j.jfns.20251302.14

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    AMA Style

    Amaranthus M. Lion’s Mane for Your Brain and Body. J Food Nutr Sci. 2025;13(2):85-92. doi: 10.11648/j.jfns.20251302.14

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  • @article{10.11648/j.jfns.20251302.14,
      author = {Mike Amaranthus},
      title = {Lion’s Mane for Your Brain and Body
    },
      journal = {Journal of Food and Nutrition Sciences},
      volume = {13},
      number = {2},
      pages = {85-92},
      doi = {10.11648/j.jfns.20251302.14},
      url = {https://doi.org/10.11648/j.jfns.20251302.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20251302.14},
      abstract = {Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health.
    },
     year = {2025}
    }
    

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