Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health.
Published in | Journal of Food and Nutrition Sciences (Volume 13, Issue 2) |
DOI | 10.11648/j.jfns.20251302.14 |
Page(s) | 85-92 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Lion’s Mane Mushroom, Hericium erinaceus, Distinguishing Features, Edibility, Supplements, Improving Brain Function, Easing Depression and Anxiety, Heart Health, Diabetes Management
[1] | Phan CW, Lee GS, Hong SL, Wong YT, Brkljača R, Urban S, Abd Malek SN, Sabaratnam V. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. Food Funct. 2014 Dec; 5(12): 3160-9. |
[2] | Černelič Bizjak, M., Jenko Pražnikar, Z., Kenig, S., Hladnik, M., Bandelj, D., Gregori, A., & Kranjc, K. (2024). Effect of erinacine A-enriched Hericium erinaceus supplementation on cognition: A randomized, double-blind, placebo-controlled pilot study. Journal of Functional Foods, 115, 106120. |
[3] | Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27; 23(1): 49. |
[4] | Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci. 2016 Nov 1; 17(11): 1810. |
[5] | Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016 Jun 7; 16: 170. |
[6] | Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3; 12: 155. |
[7] | Chiu CH, Chyau CC, Chen CC, Lee LY, Chen WP, Liu JL, Lin WH, Mong MC. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int J Mol Sci. 2018 Jan 24; 19(2): 341. |
[8] | Docherty S, Doughty FL, Smith EF. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023 Nov 20; 15(22): 4842. |
[9] | Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, Di Iorio C, Savino E, Girometta C, Brandalise F, Rossi P. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid Based Complement Alternat Med. 2019 Apr 18; 2019. |
[10] |
Ren Z, Qin T, Qiu F, Song Y, Lin D, Ma Y, Li J, Huang Y. Immunomodulatory effects of hydroxyethylated Hericium erinaceus polysaccharide on macrophages RAW264.7. Int J Biol Macromol. 2017 Dec; 105.
https://doi.org/10.1016/j.ijbiomac.2017.07104 Epub 2017 Jul 18. |
[11] |
Diling C, Chaoqun Z, Jian Y, Jian L, Jiyan S, Yizhen X, Guoxiao L. Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota. Front Immunol. 2017 Jun 12; 8: 666.
https://doi.org/10.3389/fimmu.2017.00666 Epub 2017 Jul 18. |
[12] |
Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012 Jun 6; 60(22): 5590-6.
https://doi.org/10.1021/jf300897w Epub 2012 May 24. |
[13] | Wu F, Zhou C, Zhou D, Ou S, Zhang X, Huang H. Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities. Food Funct. 2018 Jan 24; 9(1): 294-306. |
[14] |
Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceus Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun; 41(2): 94-9.
https://doi.org/10.5941/MYCO.2013.41.2.94 Epub 2013 Jun 30. |
[15] |
Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai M. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010; 74(7): 1447-51.
https://doi.org/10.1271/bbb.100130 Epub 2010 Jul 7. |
[16] |
Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed Res Int. 2014; 2014: 828149.
https://doi.org/10.1155/2014/828149 Epub 2014 May 13. |
[17] |
Mori, K., Kikuchi, H., Obara, Y., Iwashita, M., Azumi, Y., Kinugasa, S., Inatomi, S., Oshima, Y., & Nakahata, N. (2010). Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine: international journal of phytotherapy and phytopharmacology, 17(14), 1082–1085.
https://doi.org/10.1016/j.phymed.2010.05.004 Epub 2010 Jul 16. |
[18] |
He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review. Int J Biol Macromol. 2017 Apr; 97: 228-237.
https://doi.org/10.1016/j.ijbiomac.2017.01.040 Epub 2017 Jan 10. |
[19] | Liang, B., Guo, Z., Xie, F., & Zhao, A. (2013). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC complementary and alternative medicine, 13, 253. |
[20] | Zhang C, Li J, Hu C, Wang J, Zhang J, Ren Z, Song X, Jia L. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. Sci Rep. 2017 Sep 7; 7(1): 10847 |
[21] |
Lee SK, Ryu SH, Turk A, Yeon SW, Jo YH, Han YK, Hwang BY, Lee KY, Lee MK. Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus). J Ethnopharmacol. 2020 Nov 15; 262: 113197.
https://doi.org/10.1016/j.jep.2020.113197 Epub 2020 Jul 29. |
[22] |
Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. 2015; 2015: 595480
https://doi.org/10.1155/2015/595480 Epub 2015 Apr 16. |
[23] |
Nandi S., Banerjee A., Sarkar S., Chakraborty N., Acharya K. Prospecting medicinal properties of Lion’s mane mushroom. J. Food Biochem. 2021; 45: e13833
https://doi.org/10.1111/jfbc.13833 Epub ahead of print. |
[24] | Thongbai B., Rapior S., Hyde K. D., Wittstein K., Stadler M. Hericium erinaceus, an amazing medicinal mushroom. Mycol. Prog. 2015; 14: 1–23. |
[25] |
Friedman M. Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J. Agric. Food Chem. 2015; 63: 7108–7123.
https://doi.org/10.1021/acs.jafc.5b02914 Epub 2015 Aug 5. |
[26] | Khan M. A., Tania M., Liu R., Rahman M. M. Hericium erinaceus: An edible mushroom with medicinal values. J. Complement. Integr. Med. 2013; 10: 253–258. |
APA Style
Amaranthus, M. (2025). Lion’s Mane for Your Brain and Body. Journal of Food and Nutrition Sciences, 13(2), 85-92. https://doi.org/10.11648/j.jfns.20251302.14
ACS Style
Amaranthus, M. Lion’s Mane for Your Brain and Body. J. Food Nutr. Sci. 2025, 13(2), 85-92. doi: 10.11648/j.jfns.20251302.14
@article{10.11648/j.jfns.20251302.14, author = {Mike Amaranthus}, title = {Lion’s Mane for Your Brain and Body }, journal = {Journal of Food and Nutrition Sciences}, volume = {13}, number = {2}, pages = {85-92}, doi = {10.11648/j.jfns.20251302.14}, url = {https://doi.org/10.11648/j.jfns.20251302.14}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20251302.14}, abstract = {Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health. }, year = {2025} }
TY - JOUR T1 - Lion’s Mane for Your Brain and Body AU - Mike Amaranthus Y1 - 2025/03/21 PY - 2025 N1 - https://doi.org/10.11648/j.jfns.20251302.14 DO - 10.11648/j.jfns.20251302.14 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 85 EP - 92 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20251302.14 AB - Lion’s mane (Hericium erinaceus) is a unique and fascinating mushroom species. Lion’s mane is saprophytic, meaning it feeds on decaying organic material, particularly dead trees, fallen logs and wounded trees. Native to both North America and Eurasia, lion’s mane mushrooms are easy to identify and are most commonly foraged during late summer and autumn on hardwood trees. They are also cultivated and available as supplements year-round in markets, health food stores and online. Lion’s mane is a versatile ingredient in the kitchen, perfect for marinating, sautéing, barbecuing, stir-frying, or baking. Lion’s mane taste and texture is often compared to crab or other seafood, which makes it a highly sought-after edible mushroom species. Lion’s mane has a long history of medicinal use in Asian cultures, dating back millennia. Recent research indicates potential health benefits include avoiding dementia and improving cognitive function; easing depression and anxiety; reducing risk of heart disease; diminishing diabetes symptoms and improved immune system function. Evidence of improved cognitive function has been particularly significant and well documented. Certain individuals should avoid consuming lion’s mane mushrooms or supplements due to potential health risks. This includes individuals with bleeding disorders or taking blood thinners and people with diabetes taking blood sugar-lowering medications. While published peer reviewed scientific studies of lion’s mane mushrooms effects continues to grow, much of the current evidence is based on non-human animal and laboratory studies. More human research is needed to determine the full extent of its health benefits for a growing interested public. Nonetheless, the identification of specific lion’s mane bioactive compounds, hericenones and erinacines, has sparked significant interest in both research and medical communities, paving the way for future applications in brain, heart, blood, and overall health. VL - 13 IS - 2 ER -