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Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast

Received: 21 March 2023     Accepted: 12 April 2023     Published: 27 April 2023
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Abstract

The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.

Published in Journal of Food and Nutrition Sciences (Volume 11, Issue 2)
DOI 10.11648/j.jfns.20231102.13
Page(s) 43-52
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Lycopersiconesculentum, Homocysteine, Thromboembolic Diseases, LDL-cholesterol, HDL-cholesterol

References
[1] Ouamane M., 2022. Contribution to the study of tomato cultivated with the aquaponic system in the region of Biskra. Master thesis in agronomy (plant production). University Mohamed Khider of Biskra (Algeria). 50p.
[2] Belaidi S. and Dokari A., 2018. Preservation kinetics (freezing) of tomatoes and monitoring the stability of carotenoids. Master thesis, University of Bouira (Algeria). 35p.
[3] Boumendjel M.; Houamdi M.; Samar M. F.; Sabeg H.; Boutebba A. & Soltane M.., 2012. Effect of appertization heat treatments on the biochemical, nutritional and technological quality of single, double and triple concentrated tomato. Science and Technology C. Biotechnologies, (36): 51-59.
[4] LafrenièreJ.; Couillard C.; Lamarche B. & Lemieux S., 2017. Serum carotenoids as Biomarkers: a strategy to improve the validity of dietary assessment. Canadian journal of dietetics practice and research, 79 (1): 23-27.
[5] Rao A. V. and Agarwal S., 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review. Nutrition Research, 19: 305-323.
[6] Giovannucci E.; Rimm E. B.; Liu Y.; Stampfer M. J. & Willett W. C., 2002. A prospective study of tomato products, lycopene, and prostate cancer risk. J. Natl. Cancer Inst., 94: 391-398.
[7] Ahlimine A, 2017. Clinical and prognostic characteristics of metastatic prostate cancer (About 52 cases). Doctoral thesis from Sidi Mohamed Ben Abdellah University (Morocco). 134p.
[8] Borguini R. and Torres E., 2009. Tomatoes and tomato products as dietary sources of antioxidants. Food Reviews International. 25: 313-325.
[9] Panda J. L. K.; Masumbuko J-L. &Mairiaux P., 2020. Prevalence of arterial hypertension and risk factors in the workplace in the Democratic Republic of Congo: the case of the textile company in Kisangani. Ethics, Medicine and Public Health. 15, 100581.
[10] Randrianarisoa M. A.; Eid P.; Randriamihangy N. A.; Rakotomalala O. and Bélanger C., 2022. Psychosocial processes and factors associated with adult hypertension in Mahajanga, Madagascar. Science and Behavior, 32 (2): 7-16.
[11] Ouknouz N., 2019. Disorder of methionine metabolism. Doctoral thesis in Medicine, Mohammed V University, Rabat (Morocco). 212p.
[12] Akchiché N., 2009. Consequences of methyl donor deficiency on cell differentiation, survival and neuroplasticity: in vitro mechanistic approaches on neuronal lines. PhD thesis from the University Henri Poincaré, Nancy 1. 268p.
[13] Ouerdiene A.; Messelmani M.; Malek M.; Jamel Z. & Mrissa R., 2021. Involvement of vitamin B12 deficiency in the occurrence of ischemic stroke in young subjects. Revue Neurologique, 177, S98.
[14] Atae-Allah R., 2019. Classical homocystinuria due to cystathionine beta-synthase deficiency: two family cases and review of the literature. Doctoral thesis in Medicine, Mohammed V University, Rabat, Morocco. 195p.
[15] Amelal Z., 2022. Hyperhomocysteinemia and cardiovascular risk. Doctoral thesis in Medicine, Mohammed V University, Rabat, Morocco. 153p.
[16] Gherrase Y. and Bendahmane A., 2022. Effect of dietary habits on the metabolic profile of patients suffering from chronic renal failure in the Oran region. Master's thesis in Food Science (Nutrition and Dietetics), University AboubekrBelkaid-Tlemcen (Algeria). 103p.
[17] Tangara D., 2022. Evaluation of nutritional risk factors of type 2 diabetics in the six (6) CSRéfs of Bamako. Doctoral thesis in Medicine and Odonto-stomatology, University of Sciences, Techniques and Technologies of Bamako (Mali), 104p.
[18] Djeghim F.; Hameurlaine A.; Hameurlaine B., 2019. Lipid profile of renal failure in the population of Tiaret. Master's thesis in Natural and Life Sciences (Biological Sciences), Ibn Khaldoun University-Tiaret, 84p.
[19] Benkhedda S., 2001. The new recommendations of the WHO international society of Best, C. H., The first clinical use of insulin. Diabetes. 1956 (5): 65-67.
[20] Diop M., 2022. Study of therapeutic compliance in hypertensive patients followed in ambulatory care in the cardiology department of the Ziguinchor Peace Hospital. Doctoral thesis in Medicine, AssaneSeck University of Ziguinchor (Senegal), 178p.
[21] M. S. H. P., 2015. Health in motion, 2015 review. Abidjan Cote d'Ivoire. Ministry of Health and Public Hygiene, 64p.
[22] Malik K. S. and Adoubi K. A., 2018. Obesity, hypertension, and physical activity levels in a black African population. Annales de Cardiologie et d'Angéiologie. 68 (3), 133-138.
[23] Kramoh K. E.; Ekoua D.; Abina A.; Koffi K. F.; Koffi D. B.; Boka B.; Aké-Traboulsi E.; N'cho-Mottoh M-P.; Tanoh M.; Kouakou N. Y. N.; Konin C.; Anzouan-Kacou J-B.; N'guetta R.; Coulibaly I.; Xia X.; Beaney T.; Poulter N. R. &Assi A. R., 2019. May measurement Mounth 2017: an analysis of blood pressure screening results in Cote d'Ivoire-Sub-Saharan Africa. European Heart Journal Supplements. 21 (Supplement_D), D47-D49.
[24] Giovannucci E., 2007. Risk factor for prostate cancer incidence and progression in the health professionnals follow-up study. International Journal of cancer, 121 (7): 1571-1578.
[25] Costa-Rodrigues J.; Pinho O. R. & Monteiro P. R., 2018. Can lycopene be considered an effective protection against cardiovascular desease? Food chem., 245: 1148-1153.
[26] Paran E.; Novac C.; Engelhard Y. N. and Hazanhalevy I., 2009. The effects of natural antioxidants form tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc. Drugs Ther. 23 (2): 145-151.
[27] Bidié A. P.; N’guessan B.; Yapo A. F.; N’guessan J. D.; Djaman A. J., 2011. Antioxidant activities of ten medicinal plants from the Ivorian pharmacopoeia. Sci. & Nat., 8: 1-11.
[28] Nhanes (2003-2004) Hitachi 704 Cholesterol/HP (1998), Triglycérides/GPO (1997) and HDL-cholesterol/direct (1998). Roche/boehringer Mannheim Corporation, Indianapolis, IN.
[29] Dou C.; Xia D.; Zhang L.; Chen X.; Flores P.; Datta A. & Yuan C., 2005. Development of a novel enzymatic cycling assay for total homocystein. Clinical chemistry. 51 (10): 1982-1998.
[30] El-Yakin A. N.; Yousra C. &Soumaya L., 2022. Contribution to the study of some biochemical parameters in the diagnosis of arterial hypertension in pregnant women in the Tébéssa region. Master's thesis in Biological Sciences (Applied Biochemistry), LarbiTébessi-Tébessa University, 115p.
[31] Bah M. M.; Barry M.; Balde N. &Sylla A., 2018. Prevalence of hypertension in diabetics at the diabetes unit of the Kindiaregional hospital. Revue Africaine de Médecine interne, 5 (2): 50-54.
[32] Alaoui L., Jaonina G.; M Keba N., 2020. Role of minerals (Sodium, Potassium, Calcium and Magnesium) in the prevention and management of hypertension. RévueMarocaine des Sciences Agronomiqueset veterinaries, 8 (2): 333-341.
[33] Dicken F.; Aylin G.; Yoldas Z. &Lourdel S., 2022. Regulation of blood pressure - A major role of potassium intake. Medecine/Sciences, 38: 743-745.
[34] Ghobche M. and Touahri. F., 2020. Analysis of some biochemical markers in patients with arterial hypertension. Master's thesis in Biological Sciences (Toxicology), EchahidHammaLakhdar University of El-oued, 60p.
[35] Roy M. A., 2022. Directional sensitivity of the relationship between blood pressure and cerebral blood flow in young individuals trained in endurance and resistance. Master's thesis in kinesiology, Université LAVAL, Quebec (CANADA), 98p.
[36] Ugawa T.; Kakuta H.; Moritani H., 2000. YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species. Br. J. Pharmacol., 131: 63-70.
[37] Oyedepo T. A.; Babarinde S. O.; Ajayeoba T. A., 2013. Evaluation of antihyperlipidemic effect of aqueous leaves extract of moringaoleifera in alloxan induced diabetic rats. Int. J. Biochem. Res. Rev.., 3: 162-170.
[38] Nguele B. O., 2019. Screening of the AOMI in type 2 diabetics: Interest of the systolic pressure index. Doctoral thesis in Medicine and Odontostomatology, University of Sciences, Techniques and Technologies of Bamako (Mali), 131p.
[39] Koné A. S., 2022. Screening for obliterativearteriopathy of the lower limbs by measuring the systolic pressure index (SPI) in patients hospitalized in the internal medicine department of the Pont G University Hospital. Doctoral thesis in Medicine and Odontostomatology, University of Sciences, Techniques and Technologies of Bamako (Mali), 111p.
[40] Afani L.; Belbaraka R. A. & Awada, 2020. Everolimus tolerance in clinical practice: a retrospective study. Pan African Medical Journal. 36 (26): 1-7.
[41] Harnafi M.; Touiss I.; Khatib S.; Bekkouch O.; Rouis M.; Ougurram K.; Harnafi H. &Amrani. S., 2021. Phenolic extract of almond fleshy husk (Prunusamygdalus L.) restores lipid metabolism in hyperlipidemic mice and prevents plasma lipoprotein oxidation. Phytothérapie., 19 (3): 163-170.
[42] Adjenia B. S.; Akpovi C. G.; Segbo J. &Fiogbe S., 2021. Variation of uric acid and urea levels according to glomerular filtration rate in subjects followed at the Ouidah Garrison Medical-Social Center. EPAC/UAC. Rapport de stage, Licence professionnelle, Université d'Abomey-Calavi, Benin, 42p.
[43] Boulghiti F.; Mabrouki F. Z. & Rahmani I., 2022. Determination of urea and creatinine parameters in diabetics in the Adrar region. Master'sthesis of the University Ahmed Draia-Adrar. 81p.
Cite This Article
  • APA Style

    Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. (2023). Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. Journal of Food and Nutrition Sciences, 11(2), 43-52. https://doi.org/10.11648/j.jfns.20231102.13

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    ACS Style

    Dembélé Syndoux; Koffi N’dri Emmanuel; Fofana Ibrahim; Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J. Food Nutr. Sci. 2023, 11(2), 43-52. doi: 10.11648/j.jfns.20231102.13

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    AMA Style

    Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J Food Nutr Sci. 2023;11(2):43-52. doi: 10.11648/j.jfns.20231102.13

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  • @article{10.11648/j.jfns.20231102.13,
      author = {Dembélé Syndoux and Koffi N’dri Emmanuel and Fofana Ibrahim and Anin Atchibri Anin Louise},
      title = {Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast},
      journal = {Journal of Food and Nutrition Sciences},
      volume = {11},
      number = {2},
      pages = {43-52},
      doi = {10.11648/j.jfns.20231102.13},
      url = {https://doi.org/10.11648/j.jfns.20231102.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20231102.13},
      abstract = {The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast
    AU  - Dembélé Syndoux
    AU  - Koffi N’dri Emmanuel
    AU  - Fofana Ibrahim
    AU  - Anin Atchibri Anin Louise
    Y1  - 2023/04/27
    PY  - 2023
    N1  - https://doi.org/10.11648/j.jfns.20231102.13
    DO  - 10.11648/j.jfns.20231102.13
    T2  - Journal of Food and Nutrition Sciences
    JF  - Journal of Food and Nutrition Sciences
    JO  - Journal of Food and Nutrition Sciences
    SP  - 43
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2330-7293
    UR  - https://doi.org/10.11648/j.jfns.20231102.13
    AB  - The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.
    VL  - 11
    IS  - 2
    ER  - 

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Author Information
  • Training and Research Unit (Faculty) of Agriculture, Fisheries Resources and Agro-food Industry, University of San Pedro, SanPedro, Ivory Coast

  • Department of Sciences and Technologies, Advanced Teacher's Training College of Abidjan (ENS), Abidjan, Ivory Coast

  • Training and Research Unit (Faculty) of Agriculture, Fisheries Resources and Agro-food Industry, University of San Pedro, SanPedro, Ivory Coast

  • Laboratory of Nutrition and Food Safety (LNSA), Research Training-Unit of Sciences and Food Technologies, University Nangui Abrogoua, Abidjan, Ivory Coast

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