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Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats

Received: 11 March 2019     Accepted: 26 April 2019     Published: 23 May 2019
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Abstract

The present experiment is aimed to evaluate the hepatoprotective effects of purslane (PuE) and fig leaves (FlE) extracts on diclofenac-sodium (DS) induced hepatotoxicity in rats. Adult male rats were pretreated orally with PuE and FlE extracts at a dose of 10ml/kg and 200mg/kg body weight, respectively for 14 days. Co-treatment of DS 16mg/kg body weight was given orally for 7days. The present results demonstrated that the treatment with PuE and FlE combination with DS induced a marked improvement in the studied parameters. Data indicated that there were no significant differences in relative liver weight (RLW) and relative kidney weight (RKW) in group treated with PuE and FlE and /or their combination as compared to control. Plasma liver enzyme activities as well as bilirubin levels were increased in the groups receiving diclofenac only or in combination as compared with control group. However, the administration of PuE and FlE ameliorated DS induced hepatotoxicity by improving antioxidant status, decreasing inflammation, lowering TBARS and weakening the adverse effect of diclofenac on hepatic tissues. Liver injury was confirmed by the histological changes. Taken together, the present study concluded that enhancement of antioxidants and promising activity against diclofenac-induced hepatotoxicity may a result for the effect of PuE and FlE.

Published in Journal of Food and Nutrition Sciences (Volume 7, Issue 1)
DOI 10.11648/j.jfns.20190701.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Antioxidant Activity, Portulaca oleracea (Pursalne), Ficus carica (Fig Leaves), Diclofenac-Sodium, Hepatotoxicity

References
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    Mohamed Abd El-Ghany El-Sayed, Omayma El-Sayed Shaltot, Mokhtar Ibrahim Yousef, Entisar Abd El-Mohsen El-Difrawy. (2019). Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats. Journal of Food and Nutrition Sciences, 7(1), 1-7. https://doi.org/10.11648/j.jfns.20190701.11

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    ACS Style

    Mohamed Abd El-Ghany El-Sayed; Omayma El-Sayed Shaltot; Mokhtar Ibrahim Yousef; Entisar Abd El-Mohsen El-Difrawy. Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats. J. Food Nutr. Sci. 2019, 7(1), 1-7. doi: 10.11648/j.jfns.20190701.11

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    AMA Style

    Mohamed Abd El-Ghany El-Sayed, Omayma El-Sayed Shaltot, Mokhtar Ibrahim Yousef, Entisar Abd El-Mohsen El-Difrawy. Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats. J Food Nutr Sci. 2019;7(1):1-7. doi: 10.11648/j.jfns.20190701.11

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  • @article{10.11648/j.jfns.20190701.11,
      author = {Mohamed Abd El-Ghany El-Sayed and Omayma El-Sayed Shaltot and Mokhtar Ibrahim Yousef and Entisar Abd El-Mohsen El-Difrawy},
      title = {Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats},
      journal = {Journal of Food and Nutrition Sciences},
      volume = {7},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.jfns.20190701.11},
      url = {https://doi.org/10.11648/j.jfns.20190701.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20190701.11},
      abstract = {The present experiment is aimed to evaluate the hepatoprotective effects of purslane (PuE) and fig leaves (FlE) extracts on diclofenac-sodium (DS) induced hepatotoxicity in rats. Adult male rats were pretreated orally with PuE and FlE extracts at a dose of 10ml/kg and 200mg/kg body weight, respectively for 14 days. Co-treatment of DS 16mg/kg body weight was given orally for 7days. The present results demonstrated that the treatment with PuE and FlE combination with DS induced a marked improvement in the studied parameters. Data indicated that there were no significant differences in relative liver weight (RLW) and relative kidney weight (RKW) in group treated with PuE and FlE and /or their combination as compared to control. Plasma liver enzyme activities as well as bilirubin levels were increased in the groups receiving diclofenac only or in combination as compared with control group. However, the administration of PuE and FlE ameliorated DS induced hepatotoxicity by improving antioxidant status, decreasing inflammation, lowering TBARS and weakening the adverse effect of diclofenac on hepatic tissues. Liver injury was confirmed by the histological changes. Taken together, the present study concluded that enhancement of antioxidants and promising activity against diclofenac-induced hepatotoxicity may a result for the effect of PuE and FlE.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Protective Effect of Aerial Parts of Portulaca oleracea and Ficus carica Leaves Against Diclofenac-Sodium Induced Hepatotoxicity in Rats
    AU  - Mohamed Abd El-Ghany El-Sayed
    AU  - Omayma El-Sayed Shaltot
    AU  - Mokhtar Ibrahim Yousef
    AU  - Entisar Abd El-Mohsen El-Difrawy
    Y1  - 2019/05/23
    PY  - 2019
    N1  - https://doi.org/10.11648/j.jfns.20190701.11
    DO  - 10.11648/j.jfns.20190701.11
    T2  - Journal of Food and Nutrition Sciences
    JF  - Journal of Food and Nutrition Sciences
    JO  - Journal of Food and Nutrition Sciences
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2330-7293
    UR  - https://doi.org/10.11648/j.jfns.20190701.11
    AB  - The present experiment is aimed to evaluate the hepatoprotective effects of purslane (PuE) and fig leaves (FlE) extracts on diclofenac-sodium (DS) induced hepatotoxicity in rats. Adult male rats were pretreated orally with PuE and FlE extracts at a dose of 10ml/kg and 200mg/kg body weight, respectively for 14 days. Co-treatment of DS 16mg/kg body weight was given orally for 7days. The present results demonstrated that the treatment with PuE and FlE combination with DS induced a marked improvement in the studied parameters. Data indicated that there were no significant differences in relative liver weight (RLW) and relative kidney weight (RKW) in group treated with PuE and FlE and /or their combination as compared to control. Plasma liver enzyme activities as well as bilirubin levels were increased in the groups receiving diclofenac only or in combination as compared with control group. However, the administration of PuE and FlE ameliorated DS induced hepatotoxicity by improving antioxidant status, decreasing inflammation, lowering TBARS and weakening the adverse effect of diclofenac on hepatic tissues. Liver injury was confirmed by the histological changes. Taken together, the present study concluded that enhancement of antioxidants and promising activity against diclofenac-induced hepatotoxicity may a result for the effect of PuE and FlE.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Food Technology Department, Institute of Agriculture Research Center, Giza, Egypt

  • Food Science Department, Faculty of Agriculture Saba Basha, Alexandria University, Alexandria, Egypt

  • Department of Environmental Studies, Institute of Graduate Studies & Research, Alexandria University, Alexandria, Egypt

  • Food Science Department, Faculty of Agriculture Saba Basha, Alexandria University, Alexandria, Egypt

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