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Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study

Received: 13 October 2018     Accepted: 22 April 2019     Published: 10 May 2019
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Abstract

Asthma is a common heterogeneous inflammatory chronic disorder of the airways. It is “defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity often with variable expiratory airflow limitation can be demonstrated”. According to the World Health Organization, asthma is the most common chronic respiratory disorder among children. Magnesium deficiency is associated with increased contractility of smooth muscle cells. Since contractility of bronchial smooth muscle is important in patients with asthma, magnesium deficiency could negatively influence the clinical condition. On the basis of the critical role of Mg in the regulation of bronchial smooth muscle, studies have shown that intravenous application or inhalation of Mg could alleviate symptoms in asthmatic patient. In the present study which was a case-control study plasma concentration of magnesium in 50 asthma patients (27 male, 23 female) in Gaza strip were measured and compare with 50 healthy non-asthmatic controls (37 male, 13 female). Questionnaire interview was applied. The concentrations of Mg were measured by using spectrophotometer. The mean±SD magnesium level in plasma was 1.52±0.4 mg/dl, 2.02±0.27 mg/dl in cases and control respectively, there was statically significant difference between cases and control (P=0.000). Thirty-nine (78%) of cases had Mg deficiency while seven (14%) of control had Mg deficiency. Seven (14%) of patient had sensitivity to dairy product (P=0.031). Forty-five (90%) of patient had health problems especially frequent inflammation of eyes, nose and throat (P=0.000). There were significant differences between cases and control in family history of disease (P=0.000). The finding of this study demonstrate that asthmatics patient had lower plasma magnesium level compared to healthy controls in Gaza strip.

Published in Journal of Chemical, Environmental and Biological Engineering (Volume 3, Issue 1)
DOI 10.11648/j.jcebe.20190301.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Asthma, Magnesium, Chronic, Gaza Strip

References
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    Kholoud Abed El-Fattah Omran, Yusuf Khaled Elzyyan, Emad Atef Saqer, Abed Elraheem Nasrallah Safi. (2019). Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study. Journal of Chemical, Environmental and Biological Engineering, 3(1), 1-7. https://doi.org/10.11648/j.jcebe.20190301.11

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    ACS Style

    Kholoud Abed El-Fattah Omran; Yusuf Khaled Elzyyan; Emad Atef Saqer; Abed Elraheem Nasrallah Safi. Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study. J. Chem. Environ. Biol. Eng. 2019, 3(1), 1-7. doi: 10.11648/j.jcebe.20190301.11

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    AMA Style

    Kholoud Abed El-Fattah Omran, Yusuf Khaled Elzyyan, Emad Atef Saqer, Abed Elraheem Nasrallah Safi. Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study. J Chem Environ Biol Eng. 2019;3(1):1-7. doi: 10.11648/j.jcebe.20190301.11

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  • @article{10.11648/j.jcebe.20190301.11,
      author = {Kholoud Abed El-Fattah Omran and Yusuf Khaled Elzyyan and Emad Atef Saqer and Abed Elraheem Nasrallah Safi},
      title = {Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study},
      journal = {Journal of Chemical, Environmental and Biological Engineering},
      volume = {3},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.jcebe.20190301.11},
      url = {https://doi.org/10.11648/j.jcebe.20190301.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jcebe.20190301.11},
      abstract = {Asthma is a common heterogeneous inflammatory chronic disorder of the airways. It is “defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity often with variable expiratory airflow limitation can be demonstrated”. According to the World Health Organization, asthma is the most common chronic respiratory disorder among children. Magnesium deficiency is associated with increased contractility of smooth muscle cells. Since contractility of bronchial smooth muscle is important in patients with asthma, magnesium deficiency could negatively influence the clinical condition. On the basis of the critical role of Mg in the regulation of bronchial smooth muscle, studies have shown that intravenous application or inhalation of Mg could alleviate symptoms in asthmatic patient. In the present study which was a case-control study plasma concentration of magnesium in 50 asthma patients (27 male, 23 female) in Gaza strip were measured and compare with 50 healthy non-asthmatic controls (37 male, 13 female). Questionnaire interview was applied. The concentrations of Mg were measured by using spectrophotometer. The mean±SD magnesium level in plasma was 1.52±0.4 mg/dl, 2.02±0.27 mg/dl in cases and control respectively, there was statically significant difference between cases and control (P=0.000). Thirty-nine (78%) of cases had Mg deficiency while seven (14%) of control had Mg deficiency. Seven (14%) of patient had sensitivity to dairy product (P=0.031). Forty-five (90%) of patient had health problems especially frequent inflammation of eyes, nose and throat (P=0.000). There were significant differences between cases and control in family history of disease (P=0.000). The finding of this study demonstrate that asthmatics patient had lower plasma magnesium level compared to healthy controls in Gaza strip.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study
    AU  - Kholoud Abed El-Fattah Omran
    AU  - Yusuf Khaled Elzyyan
    AU  - Emad Atef Saqer
    AU  - Abed Elraheem Nasrallah Safi
    Y1  - 2019/05/10
    PY  - 2019
    N1  - https://doi.org/10.11648/j.jcebe.20190301.11
    DO  - 10.11648/j.jcebe.20190301.11
    T2  - Journal of Chemical, Environmental and Biological Engineering
    JF  - Journal of Chemical, Environmental and Biological Engineering
    JO  - Journal of Chemical, Environmental and Biological Engineering
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2640-267X
    UR  - https://doi.org/10.11648/j.jcebe.20190301.11
    AB  - Asthma is a common heterogeneous inflammatory chronic disorder of the airways. It is “defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity often with variable expiratory airflow limitation can be demonstrated”. According to the World Health Organization, asthma is the most common chronic respiratory disorder among children. Magnesium deficiency is associated with increased contractility of smooth muscle cells. Since contractility of bronchial smooth muscle is important in patients with asthma, magnesium deficiency could negatively influence the clinical condition. On the basis of the critical role of Mg in the regulation of bronchial smooth muscle, studies have shown that intravenous application or inhalation of Mg could alleviate symptoms in asthmatic patient. In the present study which was a case-control study plasma concentration of magnesium in 50 asthma patients (27 male, 23 female) in Gaza strip were measured and compare with 50 healthy non-asthmatic controls (37 male, 13 female). Questionnaire interview was applied. The concentrations of Mg were measured by using spectrophotometer. The mean±SD magnesium level in plasma was 1.52±0.4 mg/dl, 2.02±0.27 mg/dl in cases and control respectively, there was statically significant difference between cases and control (P=0.000). Thirty-nine (78%) of cases had Mg deficiency while seven (14%) of control had Mg deficiency. Seven (14%) of patient had sensitivity to dairy product (P=0.031). Forty-five (90%) of patient had health problems especially frequent inflammation of eyes, nose and throat (P=0.000). There were significant differences between cases and control in family history of disease (P=0.000). The finding of this study demonstrate that asthmatics patient had lower plasma magnesium level compared to healthy controls in Gaza strip.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine

  • Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine

  • Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine

  • Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine

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