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Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats

Received: 15 May 2017     Accepted: 24 May 2017     Published: 17 July 2017
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Abstract

Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.

Published in Journal of Anesthesiology (Volume 5, Issue 3)
DOI 10.11648/j.ja.20170503.11
Page(s) 19-23
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Propofol, Ascorbic Acid, Goat, Physiological Parameters, General Anaesthesia

References
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Cite This Article
  • APA Style

    Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. (2017). Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. International Journal of Anesthesia and Clinical Medicine, 5(3), 19-23. https://doi.org/10.11648/j.ja.20170503.11

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    ACS Style

    Veronica Inyamu Ochigbo; Joseph Olusegun Ayo; Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int. J. Anesth. Clin. Med. 2017, 5(3), 19-23. doi: 10.11648/j.ja.20170503.11

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    AMA Style

    Veronica Inyamu Ochigbo, Joseph Olusegun Ayo, Tagang Aluwong. Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats. Int J Anesth Clin Med. 2017;5(3):19-23. doi: 10.11648/j.ja.20170503.11

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  • @article{10.11648/j.ja.20170503.11,
      author = {Veronica Inyamu Ochigbo and Joseph Olusegun Ayo and Tagang Aluwong},
      title = {Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats},
      journal = {International Journal of Anesthesia and Clinical Medicine},
      volume = {5},
      number = {3},
      pages = {19-23},
      doi = {10.11648/j.ja.20170503.11},
      url = {https://doi.org/10.11648/j.ja.20170503.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20170503.11},
      abstract = {Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats
    AU  - Veronica Inyamu Ochigbo
    AU  - Joseph Olusegun Ayo
    AU  - Tagang Aluwong
    Y1  - 2017/07/17
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ja.20170503.11
    DO  - 10.11648/j.ja.20170503.11
    T2  - International Journal of Anesthesia and Clinical Medicine
    JF  - International Journal of Anesthesia and Clinical Medicine
    JO  - International Journal of Anesthesia and Clinical Medicine
    SP  - 19
    EP  - 23
    PB  - Science Publishing Group
    SN  - 2997-2698
    UR  - https://doi.org/10.11648/j.ja.20170503.11
    AB  - Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.
    VL  - 5
    IS  - 3
    ER  - 

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Author Information
  • Department of Physiology, Pharmacology and Biochemistry, University of Agriculture, Makurdi, Nigeria

  • Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria

  • Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria

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