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The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats

Received: 19 October 2016     Accepted: 5 November 2016     Published: 16 December 2016
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Abstract

The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.

Published in International Journal of Psychological and Brain Sciences (Volume 1, Issue 3)
DOI 10.11648/j.ijpbs.20160103.14
Page(s) 62-68
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Cerebral Ischemia, Cytokines, Nerve Growth Factor, Neuroprotection, Oligopeptides, Rats

References
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Cite This Article
  • APA Style

    Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. (2016). The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. International Journal of Psychological and Brain Sciences, 1(3), 62-68. https://doi.org/10.11648/j.ijpbs.20160103.14

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    ACS Style

    Roman Danylovych Deiko; Serhiy Yuriyovych Shtrygolʹ; Tetyana Victorivna Gorbach; Alexandr Alexandrovich Kolobov; Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int. J. Psychol. Brain Sci. 2016, 1(3), 62-68. doi: 10.11648/j.ijpbs.20160103.14

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    AMA Style

    Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int J Psychol Brain Sci. 2016;1(3):62-68. doi: 10.11648/j.ijpbs.20160103.14

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  • @article{10.11648/j.ijpbs.20160103.14,
      author = {Roman Danylovych Deiko and Serhiy Yuriyovych Shtrygolʹ and Tetyana Victorivna Gorbach and Alexandr Alexandrovich Kolobov and Andrey Semenovich Simbirtsev},
      title = {The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats},
      journal = {International Journal of Psychological and Brain Sciences},
      volume = {1},
      number = {3},
      pages = {62-68},
      doi = {10.11648/j.ijpbs.20160103.14},
      url = {https://doi.org/10.11648/j.ijpbs.20160103.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20160103.14},
      abstract = {The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats
    AU  - Roman Danylovych Deiko
    AU  - Serhiy Yuriyovych Shtrygolʹ
    AU  - Tetyana Victorivna Gorbach
    AU  - Alexandr Alexandrovich Kolobov
    AU  - Andrey Semenovich Simbirtsev
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    DO  - 10.11648/j.ijpbs.20160103.14
    T2  - International Journal of Psychological and Brain Sciences
    JF  - International Journal of Psychological and Brain Sciences
    JO  - International Journal of Psychological and Brain Sciences
    SP  - 62
    EP  - 68
    PB  - Science Publishing Group
    SN  - 2575-1573
    UR  - https://doi.org/10.11648/j.ijpbs.20160103.14
    AB  - The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.
    VL  - 1
    IS  - 3
    ER  - 

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Author Information
  • Department of Pharmacology, National University of Pharmacy, Kharkiv, Ukraine

  • Department of Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine

  • Department of Chemistry of Peptides, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia

  • Department of Chemistry of Peptides, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia

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