| Peer-Reviewed

Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients

Received: 18 November 2020     Accepted: 11 December 2020     Published: 10 February 2021
Views:       Downloads:
Abstract

Objectives: To evaluate the correlation between glaucomatous structural change using vertical-cup-disc ratio of the optic nerve head and functional loss measured by Frequency Doubling Technology perimetry. Materials and methods: It was a retrospective observational clinic-based study of 77 newly diagnosed Primary Open Angle Glaucoma (POAG) patients from a Private Eye clinic in a suburb of Port Harcourt city, Nigeria. They underwent clinical fundal examination with slit-lamp biomicroscope (Perkin’s slit-lamp) with 90D (Volk) lens; and Frequency Doubling Technology perimetry 24-2 threshold (Humphrey Matrix 800, 2011 Carl Zeiss Meditec, Dublin, California). The Vertical-cup-disc-ratio was assessed for each eye and the Mean deviation calculated for each eye. The relationship between VCDR and mean deviation was evaluated using Pearson’s correlation coefficient regression analysis. Result: There were 24 males (31.17%) and 53 females (68.83%). The mean age of the patients was 56.65 ± 14.33 years with a range of 37-78 years. The mean VCDR was 0.83±0.09 and 0.78±0.13 for the right and left eyes, respectively while mean FDT mean deviation was -13.99±9.33Db and -11.9.22Db for the right and left eyes, respectively. The VCDR significantly correlated with FDT mean deviation (Pearson Correlation Coefficient, r= -0.923, r2= 0.852, p-value=0.001 for the right eye; r= -0.915, r2=0.836, p-value=0.001 for the left eye. Conclusion: This study shows that at least 80% of VCDR correlated with the Mean deviation of matrix FDT amongst this cohort of POAG patients. it buttresses the fact that clinical evaluation of the optic nerve remains an indispensable tool in glaucoma diagnosis and can use to assess glaucoma severity in resource poor setting where visual field machine is not available.

Published in International Journal of Ophthalmology & Visual Science (Volume 6, Issue 1)
DOI 10.11648/j.ijovs.20210601.13
Page(s) 17-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Correlation, Vertical-cup-disc-ratio, FDT Mean Deviation, Primary Open-angle Glaucoma

References
[1] Leske MC. Open-angle glaucoma - an epidemiologic overview. Ophthalmic Epidemiol. 2007;14(4):166–172
[2] Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–267.
[3] Kapetanakis VV, Chan MP, Foster PJ, Cook DG, Owen CG, Rudnicka AR. Global variations, and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol. 2016;100(1):86–93.
[4] Betz P, Camps F, Collignon-Brach J, et al. Biometric study of the disc cup in open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol1982; 218:70–74.
[5] Garway-Heath DF, Ruben S, Viswanathan A, Hitchings RA. Vertical cup/disc ratio in relation to optic disc size: Its value in the assessment of the glaucoma suspect. Br J Ophthalmol 98; 82 (10): 1118-1124.
[6] Sommer A, Katz J, Quigley HA et al. “Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss,” Arch Ophthalmol 1991; 109(1):77-83.
[7] Johnson CA, Samuels JS, “Screening for glaucomatous visual field loss with frequency-doubling perimetry,” Investigative Ophthalmology & Visual Science. 1997; 38(2):413-425.
[8] Zarkovic A, Mora J, McKelvie J, Gamble G (2007) Relationship between second-generation frequency doubling technology and standard automated perimetry in patients with glaucoma. Clin Experiment Ophthalmol 35: 808–811.
[9] Spry PG, Hussin HM, Sparrow JM (2005) Clinical evaluation of frequency doubling technology perimetry using the Humphrey Matrix 24–2 threshold strategy. Br J Ophthalmol 89: 1031–1035.
[10] Johnson CA, Cioffi GA, Van Buskirk EM (1999) Frequency doubling technology perimetry using a 24–2 stimulus presentation pattern. Optom Vis Sci 76: 571– 581.
[11] Bozkurt B, Yilmaz PT, Irkec M (2008) Relationship between Humphrey 30–2 SITA Standard Test, Matrix 30–2 threshold test, and Heidelberg retina tomograph in ocular hypertensive and glaucoma patients. J Glaucoma 17: 203– 210.
[12] Kim TW, Zangwill LM, Bowd C, Sample PA, Shah N, et al. Retinal nerve fiber layer damage as assessed by optical coherence tomography in eyes with a visual field defect detected by frequency doubling technology perimetry but not by standard automated perimetry. Ophthalmology 2007; 114: 1053–1057.
[13] Artes PH, Hutchison DM, Nicolela MT, LeBlanc RP, Chauhan BC (2005) Threshold and variability properties of matrix frequency-doubling technology and standard automated perimetry in glaucoma. Invest Ophthalmol Vis Sci 46: 2451–2457.
[14] El Beltagi TA, Bowd C, Boden C, et al. Retinal nerve fiber layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes. Ophthalmology. 2003; 110:2185–2191.
[15] Nilforushan N, Nassiri N, Moghimi S, et al. Structure–Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry. Invest Opthalmol Vis Sci. 2012;:2740–2748.
[16] Leite MT, Zangwill LM, Weinreb RN, et al. Structure-Function relationships using the Cirrus Spectral Domain Optical Coherence Tomography and Standard Automated Perimetry. J Glaucoma. 2012; 21:49–54.
[17] Leske MC, Heijl A, Hyman L, et al. Early Manifest Glaucoma Trial: design and baseline data. Ophthalmology. 1999; 106:2144–153.
[18] Miglior S, Zeyen T, Pfeiffer N, Cunha-Vaz J, Torri V, Adamsons I, European Glaucoma Prevention Study (EGPS) Group. Results of the European Glaucoma Prevention Study. Ophthalmology. 2005; 112:366–375.
[19] Pederson JE, Anderson DR. The Mode of Progressive Disc Cupping in Ocular Hypertension and Glaucoma. Arch Ophthalmol. 1980; 98:490–495.
[20] Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007; 26:688–710.
[21] Kuang TM, Zhang C, Zangwill LM, et al. Estimating Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects. Ophthalmology. 2015; 122:2002–2009.
[22] Thomas R, Loibi K, Prarikh R. Evaluation of a glaucoma patient. Indian J Ophthalmol 2011; 59: 43-52.
[23] Ritch R, Shields M, Krupin TCaprioli J(1996) Quantitative measurements of the optic nerve head. in The glaucomas. 2 ed. eds Ritch R, Shields M, Krupin T (Mosby-Year Book, St Louis), pp 659–675.
[24] Sommer A, Pollack I, Maumenee AE. Optic disc parameters and onset of glaucomatous field loss. I. Methods and progressive changes in disc morphology. Arch Ophthalmol 1979; 97:1444–1448.
[25] Read RM, Spaeth GL. The practical clinical appraisal of the optic disc in glaucoma: The natural history of cup progression and some specific disc-field correlations. Trans Am Acad Ophthalmol Otolaryngol 1974; 78:255–267.
[26] Jonas JB, Bergua A, Schmitz-Valckenberg P, Papastathopoulos KI, Budde WM. Ranking of Optic Disc Variables for Detection of Glaucomatous Optic Nerve Damage. Invest Ophthalmol Vis Sci 2000; 41:1764-1773.
[27] Lamparter J, Russell RA, Schulze A, et al. Structure-Function Relationship between FDF, FDT, SAP, and Scanning Laser Ophthalmoscopy in Glaucoma Patients. Invest Opthalmol Vis Sci. 2012; 53:7553–9.
[28] Nathaniel GI, Ogunro A, Awoyesuku EA. The correlation between Frequency Doubling Technology Matrix Mean Deviation and Peripapillary Retinal Nerve Fibre thickness of newly diagnosed glaucoma patients. International Journal of Medical Ophthalmology 2020: vol 2 (1): 32-36.
[29] Kaushit S, Pandav SS, Ichhpujani P, Gupta A. Correlation of Frequency Doubling Perimetry with Retinal Nerve Fibre Layer thickness and Optic Disc Size in Ocular hypertensives and Glaucoma suspects. J Glaucoma 2011; 20: 366-370.
[30] Iutaka NA, Grochowski RA, Kasashara N. Correlation between Visual Field Index and other Functional and Structural Measures in Glaucoma Patients and Suspects. J Ophthalmics Vis Res 2017; 12: 53-57.
[31] Silva AL, Melo LA, Campos M, Tavares I. Correlation between peripapillary retinal nerve fibre layer thickness and visual field in glaucoma. Invest Ophthalmol Vis Sci 2013; 54: 2283.
Cite This Article
  • APA Style

    Nathaniel Godswill Inye, Pepple Godswill. (2021). Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients. International Journal of Ophthalmology & Visual Science, 6(1), 17-21. https://doi.org/10.11648/j.ijovs.20210601.13

    Copy | Download

    ACS Style

    Nathaniel Godswill Inye; Pepple Godswill. Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients. Int. J. Ophthalmol. Vis. Sci. 2021, 6(1), 17-21. doi: 10.11648/j.ijovs.20210601.13

    Copy | Download

    AMA Style

    Nathaniel Godswill Inye, Pepple Godswill. Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients. Int J Ophthalmol Vis Sci. 2021;6(1):17-21. doi: 10.11648/j.ijovs.20210601.13

    Copy | Download

  • @article{10.11648/j.ijovs.20210601.13,
      author = {Nathaniel Godswill Inye and Pepple Godswill},
      title = {Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {6},
      number = {1},
      pages = {17-21},
      doi = {10.11648/j.ijovs.20210601.13},
      url = {https://doi.org/10.11648/j.ijovs.20210601.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20210601.13},
      abstract = {Objectives: To evaluate the correlation between glaucomatous structural change using vertical-cup-disc ratio of the optic nerve head and functional loss measured by Frequency Doubling Technology perimetry. Materials and methods: It was a retrospective observational clinic-based study of 77 newly diagnosed Primary Open Angle Glaucoma (POAG) patients from a Private Eye clinic in a suburb of Port Harcourt city, Nigeria. They underwent clinical fundal examination with slit-lamp biomicroscope (Perkin’s slit-lamp) with 90D (Volk) lens; and Frequency Doubling Technology perimetry 24-2 threshold (Humphrey Matrix 800, 2011 Carl Zeiss Meditec, Dublin, California). The Vertical-cup-disc-ratio was assessed for each eye and the Mean deviation calculated for each eye. The relationship between VCDR and mean deviation was evaluated using Pearson’s correlation coefficient regression analysis. Result: There were 24 males (31.17%) and 53 females (68.83%). The mean age of the patients was 56.65 ± 14.33 years with a range of 37-78 years. The mean VCDR was 0.83±0.09 and 0.78±0.13 for the right and left eyes, respectively while mean FDT mean deviation was -13.99±9.33Db and -11.9.22Db for the right and left eyes, respectively. The VCDR significantly correlated with FDT mean deviation (Pearson Correlation Coefficient, r= -0.923, r2= 0.852, p-value=0.001 for the right eye; r= -0.915, r2=0.836, p-value=0.001 for the left eye. Conclusion: This study shows that at least 80% of VCDR correlated with the Mean deviation of matrix FDT amongst this cohort of POAG patients. it buttresses the fact that clinical evaluation of the optic nerve remains an indispensable tool in glaucoma diagnosis and can use to assess glaucoma severity in resource poor setting where visual field machine is not available.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Correlation of Vertical Cup Disc Ratio and Matrix FDT Mean Deviation in Primary Open Angle Glaucoma Patients
    AU  - Nathaniel Godswill Inye
    AU  - Pepple Godswill
    Y1  - 2021/02/10
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijovs.20210601.13
    DO  - 10.11648/j.ijovs.20210601.13
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 17
    EP  - 21
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20210601.13
    AB  - Objectives: To evaluate the correlation between glaucomatous structural change using vertical-cup-disc ratio of the optic nerve head and functional loss measured by Frequency Doubling Technology perimetry. Materials and methods: It was a retrospective observational clinic-based study of 77 newly diagnosed Primary Open Angle Glaucoma (POAG) patients from a Private Eye clinic in a suburb of Port Harcourt city, Nigeria. They underwent clinical fundal examination with slit-lamp biomicroscope (Perkin’s slit-lamp) with 90D (Volk) lens; and Frequency Doubling Technology perimetry 24-2 threshold (Humphrey Matrix 800, 2011 Carl Zeiss Meditec, Dublin, California). The Vertical-cup-disc-ratio was assessed for each eye and the Mean deviation calculated for each eye. The relationship between VCDR and mean deviation was evaluated using Pearson’s correlation coefficient regression analysis. Result: There were 24 males (31.17%) and 53 females (68.83%). The mean age of the patients was 56.65 ± 14.33 years with a range of 37-78 years. The mean VCDR was 0.83±0.09 and 0.78±0.13 for the right and left eyes, respectively while mean FDT mean deviation was -13.99±9.33Db and -11.9.22Db for the right and left eyes, respectively. The VCDR significantly correlated with FDT mean deviation (Pearson Correlation Coefficient, r= -0.923, r2= 0.852, p-value=0.001 for the right eye; r= -0.915, r2=0.836, p-value=0.001 for the left eye. Conclusion: This study shows that at least 80% of VCDR correlated with the Mean deviation of matrix FDT amongst this cohort of POAG patients. it buttresses the fact that clinical evaluation of the optic nerve remains an indispensable tool in glaucoma diagnosis and can use to assess glaucoma severity in resource poor setting where visual field machine is not available.
    VL  - 6
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

  • Rivers State University Teaching Hospital, Port Harcourt, Nigeria

  • Sections