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Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear

Received: 24 November 2019     Accepted: 24 December 2019     Published: 7 January 2020
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Abstract

Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies,such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears,in order to provide reference for clinical work.

Published in International Journal of Ophthalmology & Visual Science (Volume 5, Issue 1)
DOI 10.11648/j.ijovs.20200501.13
Page(s) 15-20
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Anti-vascular Endothelial Growth Factor, Retinal Pigment Epithelium Tear, Neovascular Age-related Macular Degeneration

References
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Cite This Article
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    Wei Liping, He Guiyun. (2020). Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. International Journal of Ophthalmology & Visual Science, 5(1), 15-20. https://doi.org/10.11648/j.ijovs.20200501.13

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    Wei Liping; He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int. J. Ophthalmol. Vis. Sci. 2020, 5(1), 15-20. doi: 10.11648/j.ijovs.20200501.13

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    AMA Style

    Wei Liping, He Guiyun. Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear. Int J Ophthalmol Vis Sci. 2020;5(1):15-20. doi: 10.11648/j.ijovs.20200501.13

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  • @article{10.11648/j.ijovs.20200501.13,
      author = {Wei Liping and He Guiyun},
      title = {Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {5},
      number = {1},
      pages = {15-20},
      doi = {10.11648/j.ijovs.20200501.13},
      url = {https://doi.org/10.11648/j.ijovs.20200501.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20200501.13},
      abstract = {Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies,such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears,in order to provide reference for clinical work.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Research Progress on Anti-Vascular Endothelial Growth Factor-Induced Retinal Pigment Epithelium Tear
    AU  - Wei Liping
    AU  - He Guiyun
    Y1  - 2020/01/07
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijovs.20200501.13
    DO  - 10.11648/j.ijovs.20200501.13
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 15
    EP  - 20
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20200501.13
    AB  - Various eye diseases can cause retinal pigment epithelium (RPE) tear. RPE tear is common in neovascular age-related macular degeneration (nAMD). The injection of anti-vascular endothelial growth factor (VEGF) increases the risk of PRE tear, the mechanism of which is a sudden change in intraocular pressure during drug injection, vitreous macular traction, destruction of the RPE tight junction barrier and secondary contraction and fibrosis of the choroidal neovascular membrane. The height of pigment epithelial detachment (PED) is an important risk factor for RPE tear in patients with nAMD after injection of anti-VEGF drugs. The diagnosis of RPE tears primarily relies on imaging studies,such as fundus photography、fundus autofluorescence、optical coherence tomography and so on. Regarding treatment, we must first determine whether the patient has a RPE tear, or whether there are risk factors related to the RPE tear, and then perform the corresponding personalized treatment. If possible, consider stem cell transplant alternatives. There is no proven method to prevent RPE tear so far. This article will review and summarize the research progress in the pathogenesis, risk factors, diagnosis, treatment and prevention of RPE tear caused by anti-VEGF drugs, and further improve the understanding of RPE tears,in order to provide reference for clinical work.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Medical College, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China

  • Hunan Provincial People's Hospital, Changsha, China

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