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Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System

Received: 24 March 2017     Accepted: 22 April 2017     Published: 21 September 2017
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Abstract

A common diseased condition includes eye infections like conductivities and corneal disorder such as glaucoma etc. Some of the typical classes of drugs used for the ocular delivery are miotics, mydriatics/cycloplegics, anti-inflammatory, anti-infective, surgical adjuvant and diagnostics. This review presents an outline of the prospective of chitosan-based nanomedicine for the treatment of ocular infection for improving the corneal residence time and in vitro bioavailability. In addition, its minimum toxicity and good ocular tolerance, chitosan exhibits constructive biological behavior, like bioadhesion and good permeability with optimum physiochemical characteristics, which make it a unique biocompatible material for the ophthalmic application. The review summarizes the application of chitosan based nanomedicine such as nanoparticles, solid lipid nanoparticles, nanosuspention, nanosponge and nanogels for the treatment of ocular diseases. The results reported provide evidence of the potential of chitosan being natural polymers for enhancing therapeutics effect of drugs.

Published in International Journal of Ophthalmology & Visual Science (Volume 2, Issue 4)
DOI 10.11648/j.ijovs.20170204.14
Page(s) 98-105
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Chitosan Nanoparticles, Nanomedicine, Corneal Residence Time, in Vitro Bioavailability

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    Varsha Gharge, Pravin Pawar. (2017). Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System. International Journal of Ophthalmology & Visual Science, 2(4), 98-105. https://doi.org/10.11648/j.ijovs.20170204.14

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    Varsha Gharge; Pravin Pawar. Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System. Int. J. Ophthalmol. Vis. Sci. 2017, 2(4), 98-105. doi: 10.11648/j.ijovs.20170204.14

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    Varsha Gharge, Pravin Pawar. Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System. Int J Ophthalmol Vis Sci. 2017;2(4):98-105. doi: 10.11648/j.ijovs.20170204.14

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  • @article{10.11648/j.ijovs.20170204.14,
      author = {Varsha Gharge and Pravin Pawar},
      title = {Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {2},
      number = {4},
      pages = {98-105},
      doi = {10.11648/j.ijovs.20170204.14},
      url = {https://doi.org/10.11648/j.ijovs.20170204.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20170204.14},
      abstract = {A common diseased condition includes eye infections like conductivities and corneal disorder such as glaucoma etc. Some of the typical classes of drugs used for the ocular delivery are miotics, mydriatics/cycloplegics, anti-inflammatory, anti-infective, surgical adjuvant and diagnostics. This review presents an outline of the prospective of chitosan-based nanomedicine for the treatment of ocular infection for improving the corneal residence time and in vitro bioavailability. In addition, its minimum toxicity and good ocular tolerance, chitosan exhibits constructive biological behavior, like bioadhesion and good permeability with optimum physiochemical characteristics, which make it a unique biocompatible material for the ophthalmic application. The review summarizes the application of chitosan based nanomedicine such as nanoparticles, solid lipid nanoparticles, nanosuspention, nanosponge and nanogels for the treatment of ocular diseases. The results reported provide evidence of the potential of chitosan being natural polymers for enhancing therapeutics effect of drugs.},
     year = {2017}
    }
    

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    T1  - Recent Trends in Chitosan Based Nanotechnology: A Reference to Ocular Drug Delivery System
    AU  - Varsha Gharge
    AU  - Pravin Pawar
    Y1  - 2017/09/21
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijovs.20170204.14
    DO  - 10.11648/j.ijovs.20170204.14
    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 98
    EP  - 105
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20170204.14
    AB  - A common diseased condition includes eye infections like conductivities and corneal disorder such as glaucoma etc. Some of the typical classes of drugs used for the ocular delivery are miotics, mydriatics/cycloplegics, anti-inflammatory, anti-infective, surgical adjuvant and diagnostics. This review presents an outline of the prospective of chitosan-based nanomedicine for the treatment of ocular infection for improving the corneal residence time and in vitro bioavailability. In addition, its minimum toxicity and good ocular tolerance, chitosan exhibits constructive biological behavior, like bioadhesion and good permeability with optimum physiochemical characteristics, which make it a unique biocompatible material for the ophthalmic application. The review summarizes the application of chitosan based nanomedicine such as nanoparticles, solid lipid nanoparticles, nanosuspention, nanosponge and nanogels for the treatment of ocular diseases. The results reported provide evidence of the potential of chitosan being natural polymers for enhancing therapeutics effect of drugs.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education & Research, Shivaji University, Kolhapur, India

  • Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education & Research, Shivaji University, Kolhapur, India

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