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Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method

Received: 17 March 2023     Accepted: 1 April 2023     Published: 18 April 2023
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Abstract

β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p < 0.05 using SPSS 16.0 software. As results, moderate negative correlation between serum ferritin and liver, spleen MRI T2* relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.

Published in International Journal of Medical Imaging (Volume 11, Issue 1)
DOI 10.11648/j.ijmi.20231101.14
Page(s) 21-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Serum Ferritin, MRI T2*, β -Thalassemia Major

References
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[3] Andrew T2*: an ROC study. The Internet Journal of Gastroenterology, 2009, 8 (2): 1528-1532.
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    Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. (2023). Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. International Journal of Medical Imaging, 11(1), 21-24. https://doi.org/10.11648/j.ijmi.20231101.14

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    ACS Style

    Nga Thi Ho Nguyen; Phuoc Van Le; Phuoc Thanh Bui; Dung Van Le; Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int. J. Med. Imaging 2023, 11(1), 21-24. doi: 10.11648/j.ijmi.20231101.14

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    AMA Style

    Nga Thi Ho Nguyen, Phuoc Van Le, Phuoc Thanh Bui, Dung Van Le, Lam Hoang Nguyen, et al. Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method. Int J Med Imaging. 2023;11(1):21-24. doi: 10.11648/j.ijmi.20231101.14

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  • @article{10.11648/j.ijmi.20231101.14,
      author = {Nga Thi Ho Nguyen and Phuoc Van Le and Phuoc Thanh Bui and Dung Van Le and Lam Hoang Nguyen and Van Bich Thi Le and Pham Van Bui},
      title = {Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method},
      journal = {International Journal of Medical Imaging},
      volume = {11},
      number = {1},
      pages = {21-24},
      doi = {10.11648/j.ijmi.20231101.14},
      url = {https://doi.org/10.11648/j.ijmi.20231101.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20231101.14},
      abstract = {β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Evaluated the Correlation Between Serum Ferritin and Iron Overload of Liver, Spleen and Heart in β-Thalassemia Major Patients by MRI T2* Method
    AU  - Nga Thi Ho Nguyen
    AU  - Phuoc Van Le
    AU  - Phuoc Thanh Bui
    AU  - Dung Van Le
    AU  - Lam Hoang Nguyen
    AU  - Van Bich Thi Le
    AU  - Pham Van Bui
    Y1  - 2023/04/18
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijmi.20231101.14
    DO  - 10.11648/j.ijmi.20231101.14
    T2  - International Journal of Medical Imaging
    JF  - International Journal of Medical Imaging
    JO  - International Journal of Medical Imaging
    SP  - 21
    EP  - 24
    PB  - Science Publishing Group
    SN  - 2330-832X
    UR  - https://doi.org/10.11648/j.ijmi.20231101.14
    AB  - β-Thalassemia major often results in an excess of iron in the body due to frequent blood transfusions and enhanced absorption of iron in the gastrointestinal tract. Early detection of this condition and administering sufficient iron chelator therapy can significantly decrease the risk of complications and fatalities resulting from iron overload. MRI (Magnetic Resonance Imaging) T2* is an accurate non-invasive method for assessing organ iron overload in β-Thalassaemia major patients. This study evaluated the correlation between serum ferritin and iron overload of liver, spleen, and heart in β -Thalassaemia major patients by MRI T2* method. The design was a cross-section, descriptive study. We used MRI-T2* to evaluate the correlation between serum ferritin and iron overload of liver, spleen, and heart in 24 Thalassaemia major patients admitted in Cho Ray hospital from 10/2013 to 1/2014, using a 1.5T MRI system (Siemens) with a body coil. T2* measurements were taken in the liver, spleen, and myocardium using different gradient echo pulse sequences. T2* values were calculated within homogeneous regions of interest (ROI) in the liver avoiding major blood vessels, spleen, and the entire thickness of the interventricular septum in the myocardium. Pearson correlation coefficient was used to evaluate correlations in the study with a significance threshold of p * relaxation time (r = 0.57 and 0.755) and a weak negative correlation between serum ferritin and heart MRI T2* relaxation time (r = 0.303). Liver and heart MRI T2* readings were poorly correlated (r = 0.28). In conclusion, MRI T2* is useful to evaluate the iron overload status in β thalassemia patients.
    VL  - 11
    IS  - 1
    ER  - 

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Author Information
  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

  • Department of Surgery, Pham Ngoc Thach Medical University, Ho Chi Minh City, Vietnam

  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

  • Department of Radiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam

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