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Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography

Received: 24 August 2020     Accepted: 6 October 2020     Published: 16 October 2020
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Abstract

Background: 320-detector row dynamic volume computed tomography (CT) scanner was widely applied in coronary CT angiography (CCTA),which made it possible to reduce the volume of contrast material (CM) used. Some studies have reported the feasibility of reducing the CM in 320-detector row CCTA using a weight-adapted injection protocol. However, it hasn't been studied to investigate what was the significance of increasing the injection rate with a lower volume of CM. Objective: To investigate the feasibility of reducing the body weight-adapted volume of CM by increasing the injection rate in 320-detector row CCTA. Methods: A total of 116 patients who underwent 320-detector row CCTA were divided into three groups. Group A received 0.7 ml/kg of CM (350 mg I/ml) at an injection rate of 5.0 ml/s (n = 40); group B received 0.6 ml/kg of CM at 5.5 ml/s (n = 39); group C received 0.5 ml/kg of CM at 6.0 ml/s (n = 37). A 30-ml 0.9% saline chaser was administered after the CM. Enhancement values of the cardiovascular territories and coronary arteries were measured and compared. Image quality was also evaluated and compared among the three groups. Result: Enhancement values of the proximal coronary arterial segments for group C were significantly lower than those for groups A and B (all, P < 0.05), whereas there were no significant differences between groups A and B (all, P > 0.05). Similar statistical results were found in the proportion of proximal coronary arterial segments with enhancement values ≥ 300 HU, image quality ratings and the proportion of the main of coronary arterial segments with image quality scores ≥ 3 on both per-vessel and per-patient analyses. Conclusion: At least 0.6 ml/kg with 350 mg I/ml of CM at 5.5 ml/s injection rate was required to achieve sufficient and credible evaluation of the coronary artery in 320-detector row CCTA.

Published in International Journal of Medical Imaging (Volume 8, Issue 4)
DOI 10.11648/j.ijmi.20200804.11
Page(s) 65-71
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Coronary CT Angiography, 320-detector Row CT, Contrast Material, Injection Rate, Image Quality

References
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[2] Fuchs A, Kühl JT, Chen MY, et al. Subtraction CT angiography improves evaluation of significant coronary artery disease in patients with severe calcifications or stents-the C-Sub 320 multicenter trial.[J]. European Radiology. 2018, 28 (10): 4077-4085.
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[4] Jai-Sing Y, Yan-Ru P, Shih-Chang T, et al. The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM)[J]. Biomedicine, 2018, 8 (1): 1-11.
[5] Sun G, Chen JY, Liu Y. Contrast-Induced Nephropathy: Further Investigations About Risk Factors Are Required [J]. Angiology. 2019, 70 (8): 784-785.
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[7] Bao L. Optimization of contrast dose of the 320-slice spiral CT coronary angiography [J]. Journal of Imaging Research and Medical Applications, 2018, 2 (13): 37-38.
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[9] Shirasaka T, Nagao M, Yamasaki Y, et al. Feasible scan timing for 320-row coronary CT angiography generated by the time to peak in the ascending aorta [J]. Clinical imaging, 2019, 54: 153-158.
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[12] Sheng-Jia G U, Le Q, Ze-Peng M A, et al. A Prospective Study of Optimized Contrast Media Injection Protocol for Coronary Computed Tomography Angiography [J]. Chinese Computed Medical Imaging, 2018, 24 (01): 32-37.
[13] Kawaguchi N, Kurata A, Kido T,, et al. Optimization of coronary attenuation in coronary computed tomography angiography using diluted contrast material [J]. Circulation journal, 2014, 78 (3): 662-670.
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[16] Sharma R K, Gottlieb I, João A. C. Lima. Cardiovascular CT for Perfusion and Delayed Contrast Enhancement Imaging [M] / Cardiac CT Imaging. Springer International Publishing, 2016: 211-220.
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    Wencai Yang, Zhaohui Xian, Feifeng Qiu, Nengwei Wang, Sihua Liang, et al. (2020). Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography. International Journal of Medical Imaging, 8(4), 65-71. https://doi.org/10.11648/j.ijmi.20200804.11

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    ACS Style

    Wencai Yang; Zhaohui Xian; Feifeng Qiu; Nengwei Wang; Sihua Liang, et al. Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography. Int. J. Med. Imaging 2020, 8(4), 65-71. doi: 10.11648/j.ijmi.20200804.11

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    AMA Style

    Wencai Yang, Zhaohui Xian, Feifeng Qiu, Nengwei Wang, Sihua Liang, et al. Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography. Int J Med Imaging. 2020;8(4):65-71. doi: 10.11648/j.ijmi.20200804.11

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  • @article{10.11648/j.ijmi.20200804.11,
      author = {Wencai Yang and Zhaohui Xian and Feifeng Qiu and Nengwei Wang and Sihua Liang and Lin Qiu},
      title = {Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography},
      journal = {International Journal of Medical Imaging},
      volume = {8},
      number = {4},
      pages = {65-71},
      doi = {10.11648/j.ijmi.20200804.11},
      url = {https://doi.org/10.11648/j.ijmi.20200804.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20200804.11},
      abstract = {Background: 320-detector row dynamic volume computed tomography (CT) scanner was widely applied in coronary CT angiography (CCTA),which made it possible to reduce the volume of contrast material (CM) used. Some studies have reported the feasibility of reducing the CM in 320-detector row CCTA using a weight-adapted injection protocol. However, it hasn't been studied to investigate what was the significance of increasing the injection rate with a lower volume of CM. Objective: To investigate the feasibility of reducing the body weight-adapted volume of CM by increasing the injection rate in 320-detector row CCTA. Methods: A total of 116 patients who underwent 320-detector row CCTA were divided into three groups. Group A received 0.7 ml/kg of CM (350 mg I/ml) at an injection rate of 5.0 ml/s (n = 40); group B received 0.6 ml/kg of CM at 5.5 ml/s (n = 39); group C received 0.5 ml/kg of CM at 6.0 ml/s (n = 37). A 30-ml 0.9% saline chaser was administered after the CM. Enhancement values of the cardiovascular territories and coronary arteries were measured and compared. Image quality was also evaluated and compared among the three groups. Result: Enhancement values of the proximal coronary arterial segments for group C were significantly lower than those for groups A and B (all, P P > 0.05). Similar statistical results were found in the proportion of proximal coronary arterial segments with enhancement values ≥ 300 HU, image quality ratings and the proportion of the main of coronary arterial segments with image quality scores ≥ 3 on both per-vessel and per-patient analyses. Conclusion: At least 0.6 ml/kg with 350 mg I/ml of CM at 5.5 ml/s injection rate was required to achieve sufficient and credible evaluation of the coronary artery in 320-detector row CCTA.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Reduction of the Body Weight-adapted Volume of Contrast Material by Increasing the Injection Rate in 320-detector Row Coronary CT Angiography
    AU  - Wencai Yang
    AU  - Zhaohui Xian
    AU  - Feifeng Qiu
    AU  - Nengwei Wang
    AU  - Sihua Liang
    AU  - Lin Qiu
    Y1  - 2020/10/16
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijmi.20200804.11
    DO  - 10.11648/j.ijmi.20200804.11
    T2  - International Journal of Medical Imaging
    JF  - International Journal of Medical Imaging
    JO  - International Journal of Medical Imaging
    SP  - 65
    EP  - 71
    PB  - Science Publishing Group
    SN  - 2330-832X
    UR  - https://doi.org/10.11648/j.ijmi.20200804.11
    AB  - Background: 320-detector row dynamic volume computed tomography (CT) scanner was widely applied in coronary CT angiography (CCTA),which made it possible to reduce the volume of contrast material (CM) used. Some studies have reported the feasibility of reducing the CM in 320-detector row CCTA using a weight-adapted injection protocol. However, it hasn't been studied to investigate what was the significance of increasing the injection rate with a lower volume of CM. Objective: To investigate the feasibility of reducing the body weight-adapted volume of CM by increasing the injection rate in 320-detector row CCTA. Methods: A total of 116 patients who underwent 320-detector row CCTA were divided into three groups. Group A received 0.7 ml/kg of CM (350 mg I/ml) at an injection rate of 5.0 ml/s (n = 40); group B received 0.6 ml/kg of CM at 5.5 ml/s (n = 39); group C received 0.5 ml/kg of CM at 6.0 ml/s (n = 37). A 30-ml 0.9% saline chaser was administered after the CM. Enhancement values of the cardiovascular territories and coronary arteries were measured and compared. Image quality was also evaluated and compared among the three groups. Result: Enhancement values of the proximal coronary arterial segments for group C were significantly lower than those for groups A and B (all, P P > 0.05). Similar statistical results were found in the proportion of proximal coronary arterial segments with enhancement values ≥ 300 HU, image quality ratings and the proportion of the main of coronary arterial segments with image quality scores ≥ 3 on both per-vessel and per-patient analyses. Conclusion: At least 0.6 ml/kg with 350 mg I/ml of CM at 5.5 ml/s injection rate was required to achieve sufficient and credible evaluation of the coronary artery in 320-detector row CCTA.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • nterventional Operating Room, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • nterventional Operating Room, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • nterventional Operating Room, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Medical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Medical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Medical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, China

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