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In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography

Received: 16 October 2015     Accepted: 24 October 2015     Published: 10 November 2015
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Abstract

Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.

Published in International Journal of Medical Imaging (Volume 3, Issue 6)
DOI 10.11648/j.ijmi.20150306.12
Page(s) 110-113
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

OCT, 3D Reconstruction, PAD

References
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Cite This Article
  • APA Style

    Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. (2015). In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. International Journal of Medical Imaging, 3(6), 110-113. https://doi.org/10.11648/j.ijmi.20150306.12

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    ACS Style

    Mehmet Cilingiroglu; Massoud Leesar; Taylor Hoyt; Austin Mcelroy; Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int. J. Med. Imaging 2015, 3(6), 110-113. doi: 10.11648/j.ijmi.20150306.12

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    AMA Style

    Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int J Med Imaging. 2015;3(6):110-113. doi: 10.11648/j.ijmi.20150306.12

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  • @article{10.11648/j.ijmi.20150306.12,
      author = {Mehmet Cilingiroglu and Massoud Leesar and Taylor Hoyt and Austin Mcelroy and Thomas Milner and Konstantinos Marmagkiolis and Marc D. Feldman and Vasili Lendel},
      title = {In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography},
      journal = {International Journal of Medical Imaging},
      volume = {3},
      number = {6},
      pages = {110-113},
      doi = {10.11648/j.ijmi.20150306.12},
      url = {https://doi.org/10.11648/j.ijmi.20150306.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20150306.12},
      abstract = {Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography
    AU  - Mehmet Cilingiroglu
    AU  - Massoud Leesar
    AU  - Taylor Hoyt
    AU  - Austin Mcelroy
    AU  - Thomas Milner
    AU  - Konstantinos Marmagkiolis
    AU  - Marc D. Feldman
    AU  - Vasili Lendel
    Y1  - 2015/11/10
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ijmi.20150306.12
    DO  - 10.11648/j.ijmi.20150306.12
    T2  - International Journal of Medical Imaging
    JF  - International Journal of Medical Imaging
    JO  - International Journal of Medical Imaging
    SP  - 110
    EP  - 113
    PB  - Science Publishing Group
    SN  - 2330-832X
    UR  - https://doi.org/10.11648/j.ijmi.20150306.12
    AB  - Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • Arkansas Heart Hospital, Little Rock, AR, USA/Koc University, School of Medicine, Istanbul, Turkey

  • University of Alabama at Birmingham, Department of Medicine, Section of Cardiology,Birmingham, AL,USA

  • University of Texas Health Sciences Center at San Antonio, Department of Medicine, Section of Cardiology, San Antonio, TX, San Antonio, TX, USA

  • University of Texas at Austin, Cockrell School of Biomedical Engineering, Austin, TX, USA

  • University of Texas at Austin, Cockrell School of Biomedical Engineering, Austin, TX, USA

  • Citizens Memorial Hospital, Bolivar, MO, USA /University of Missouri, Columbia MO, USA

  • University of Texas Health Sciences Center at San Antonio, Department of Medicine, Section of Cardiology, San Antonio, TX, San Antonio, TX, USA

  • Arkansas Heart Hospital, Little Rock, AR, USA/Koc University, School of Medicine, Istanbul, Turkey

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