Research Article | | Peer-Reviewed

Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study

Received: 26 March 2025     Accepted: 2 April 2025     Published: 28 April 2025
Views:       Downloads:
Abstract

Background of the Study: Upper Gastrointestinal bleeding (UGIB) remains to be a significant clinical concern for geriatric patients due to their prolonged hospital stay and higher mortality and morbidity rates. The clinical profile of the geriatric patients are important aspects to consider, given that there is limited data in elderly population. Objective: The study is aimed to determine the clinical profile of elderly patients with UGIB admitted in a Tertiary Hospital from January 2024 to June 2024. Methods: This is a retrospective cohort study among elderly Filipino patients aged 60 years and above; admitted as UGIB and underwent esophagogastroduodenoscopy (EGD). Baseline Demographic, clinical presentation, laboratory results, endoscopic findings, prognosis and predictors of mortality were evaluated. Statistical analysis involved the application of Pearson’s chi-square, Fisher’s exact test, T-test and univariate and multivariate logistic regression analysis. Results: Among 102 admitted elderly patients with UGIB, 67 of them underwent EGD, thus were included in the study; 43 (64.18%) were male and 24 (35.82%) were female with the median age of 69.66 (±7.40) years. The prevalence rate of UGIB among elderly Filipino is 8.90%. 50 of those patients (74.63%) had comorbidities, the most common were: hypertension 38 (56.72%), diabetes mellitus 19 (28.36%) and chronic kidney diseases (13.43%). Patients presented mostly with melena (67.16%), generalized body weakness (53.73%) and 19.40% had abdominal pain. During endoscopy, (47.76%) was due to gastritis and gastric ulcer (19.40%). Mortality rate was higher in patients admitted at the ICU. No association was noted between the patients’ mortality and their sex, age, comorbidities, medications used, clinical findings, INR, BUN, hemoglobin, blood transfusion, and endoscopic findings. Conclusion: The present study reported that elderly patients with UGIB were male, with hypertension as the most common comorbidity. EGD findings showed gastritis as the most common cause of UGIB. Mortality rate is higher in patients admitted at the ICU. None of the variables showed significant differences in terms of predictors of mortality.

Published in International Journal of Gastroenterology (Volume 9, Issue 1)
DOI 10.11648/j.ijg.20250901.13
Page(s) 15-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Upper Gastrointestinal Bleed, Elderly, Clinical Profile, Melena, Predictors of Mortality

References
[1] Elkhatib FA. Acute upper gastrointestinal bleeding among early and late elderly patients. Dig Dis Sci. 2010 Oct; 55(10): 3007-9.
[2] Thomopoulos KC, Vagenas KA, Vagianos CE, Margaritis VG, Blikas AP, Katsakoulis EC, et al. Changes in aetiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 2004; 16: 177-82.
[3] Ahmed, A., & Stanley, A. J. (2012). Acute upper gastrointestinal bleeding in the elderly. Drugs & Aging, 29(12), 933-940.
[4] Alkhatib, A. A., Elkhatib, F. A., Alkhatib, A. A., Maldonado, A., Abubakr, S. M., & Adler, D. G. (2010). Acute upper gastrointestinal bleeding in elderly people: Presentations, endoscopic findings, and outcomes. Journal of the American Geriatrics Society, 58(1), 182-185.
[5] Thongbai T, Thanapirom K, Ridtitid W, Rerknimitr R, Thungsuk R, Noophun P, Et Al. Factors Predicting Mortality Of Elderly Patients With Acute Upper Gastrointestinal Bleeding. Asian Biomedicine. 2016 Apr 1; 10(2): 115-22.
[6] Chandail, Vijantsingh, And Pranav Mahajan. “Etiological And Endoscopic Profile Of Middle Aged And Elderly Patients With Upper Gastrointestinal Bleeding In A Tertiary Care Hospital In North India: A Retrospective Analysis.” Journal Of Mid-Life Health, Vol. 8, No. 3, 2017, P. 137,
[7] Bodh, V., Sharma, B., Kumar, R., & Sharma, R. (2021). Current Trends in Etiological Profile of Acute Upper Gastrointestinal Bleeding in Northern India: A Retrospective Analysis of 5-Year Endoscopic Data. Journal of Digestive Endoscopy, 12(01), 031-035.
[8] Abella, A. et al, A 5-year retrospective study on upper gastrointestinal bleeding based on esophago-gastro-duodenoscopy in Manila Central University Hospital. (2010-2014). 1(1),
[9] Ching, M. C., Domingo, E., Gloria, V., Makalinao, A., & Limson, A. (1985, August 31). Upper gastrointestinal hemorrhage in the elderly. Philippine Journal of Internal Medicine.
[10] Lenti, M. V., Pasina, L., Cococcia, S., Cortesi, L., Miceli, E., Caccia Dominioni, C., Pisati, M., Mengoli, C., Perticone, F., Nobili, A., Di Sabatino, A., & Corazza, G. R. (2019b). Mortality rate and risk factors for gastrointestinal bleeding in elderly patients. European Journal of Internal Medicine, 61, 54-61.
[11] Hossam, M., Abdel-Fattah, S., Elkholy, S. et al. Acute gastrointestinal bleeding in Egyptian elderly patients: real-life experience. Egypt Liver Journal 12, 33 (2022).
[12] Hao, W., Liu, A., Zhu, H. et al. Risk factors and management of gastrointestinal bleeding in patients with or without antiplatelet and anticoagulation therapy: a multicenter real-world prospective study. BMC Gastroenterol 24, 155 (2024).
[13] Charatcharoenwitthaya P, Pausawasdi N, Laosanguaneak N, Bubthamala J, Tanwandee T, Leelakusolvong S. Characteristics And Outcomes Of Acute Upper Gastrointestinal Bleeding After Therapeutic Endoscopy In The Elderly. World J Gastroenterol. 2011; 28; 17: 3724-32.
[14] Minoru Tomizawa, Fuminobu Shinozaki, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, And Naoki Ishige. Patient Characteristics With High Or Low Blood Urea Nitrogen In Upper Gastrointestinal Bleeding. World Journal Of Gastroenterology (2015) 21(24): 7500-7505.
[15] Sato, K., & Lapus, J. (2018). Factors Predicting Mortality In Patients With Acute Upper Gastrointestinal Bleeding In Cardinal Santos Medical Center (P. 8) [Review Of Factors Predicting Mortality In Patients With Acute Upper Gastrointestinal Bleeding In Cardinal Santos Medical Center.
[16] Anand, D. et al. (2014) ‘Clinical and endoscopic profile of patients with upper gastrointestinal bleeding at tertiary care center of North India’, Journal of Digestive Endoscopy, 05(04), pp. 139-143.
[17] Elsebaey Ma, Elashry H, Elbedewy Ta, Elhadidy Aa, Esheba Ne, Ezat S, Et Al. Predictors Of In-Hospital Mortality In A Cohort Of Elderly Egyptian Patients With Acute Upper Gastrointestinal Bleeding.Medicine (Baltimore). 2018; 97: E0403.
Cite This Article
  • APA Style

    Imperial, M. J. C., Lim-Teodoro, A., Sato, K. (2025). Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study. International Journal of Gastroenterology, 9(1), 15-24. https://doi.org/10.11648/j.ijg.20250901.13

    Copy | Download

    ACS Style

    Imperial, M. J. C.; Lim-Teodoro, A.; Sato, K. Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study. Int. J. Gastroenterol. 2025, 9(1), 15-24. doi: 10.11648/j.ijg.20250901.13

    Copy | Download

    AMA Style

    Imperial MJC, Lim-Teodoro A, Sato K. Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study. Int J Gastroenterol. 2025;9(1):15-24. doi: 10.11648/j.ijg.20250901.13

    Copy | Download

  • @article{10.11648/j.ijg.20250901.13,
      author = {Marie Jeramiah Concubierta Imperial and Adolf Lim-Teodoro and Kenji Sato},
      title = {Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study
    },
      journal = {International Journal of Gastroenterology},
      volume = {9},
      number = {1},
      pages = {15-24},
      doi = {10.11648/j.ijg.20250901.13},
      url = {https://doi.org/10.11648/j.ijg.20250901.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20250901.13},
      abstract = {Background of the Study: Upper Gastrointestinal bleeding (UGIB) remains to be a significant clinical concern for geriatric patients due to their prolonged hospital stay and higher mortality and morbidity rates. The clinical profile of the geriatric patients are important aspects to consider, given that there is limited data in elderly population. Objective: The study is aimed to determine the clinical profile of elderly patients with UGIB admitted in a Tertiary Hospital from January 2024 to June 2024. Methods: This is a retrospective cohort study among elderly Filipino patients aged 60 years and above; admitted as UGIB and underwent esophagogastroduodenoscopy (EGD). Baseline Demographic, clinical presentation, laboratory results, endoscopic findings, prognosis and predictors of mortality were evaluated. Statistical analysis involved the application of Pearson’s chi-square, Fisher’s exact test, T-test and univariate and multivariate logistic regression analysis. Results: Among 102 admitted elderly patients with UGIB, 67 of them underwent EGD, thus were included in the study; 43 (64.18%) were male and 24 (35.82%) were female with the median age of 69.66 (±7.40) years. The prevalence rate of UGIB among elderly Filipino is 8.90%. 50 of those patients (74.63%) had comorbidities, the most common were: hypertension 38 (56.72%), diabetes mellitus 19 (28.36%) and chronic kidney diseases (13.43%). Patients presented mostly with melena (67.16%), generalized body weakness (53.73%) and 19.40% had abdominal pain. During endoscopy, (47.76%) was due to gastritis and gastric ulcer (19.40%). Mortality rate was higher in patients admitted at the ICU. No association was noted between the patients’ mortality and their sex, age, comorbidities, medications used, clinical findings, INR, BUN, hemoglobin, blood transfusion, and endoscopic findings. Conclusion: The present study reported that elderly patients with UGIB were male, with hypertension as the most common comorbidity. EGD findings showed gastritis as the most common cause of UGIB. Mortality rate is higher in patients admitted at the ICU. None of the variables showed significant differences in terms of predictors of mortality.
    },
     year = {2025}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Clinical Profile of Filipino Elderly Patients with Upper Gastrointestinal Bleeding Admitted in a Tertiary Hospital: A Retrospective Cohort Study
    
    AU  - Marie Jeramiah Concubierta Imperial
    AU  - Adolf Lim-Teodoro
    AU  - Kenji Sato
    Y1  - 2025/04/28
    PY  - 2025
    N1  - https://doi.org/10.11648/j.ijg.20250901.13
    DO  - 10.11648/j.ijg.20250901.13
    T2  - International Journal of Gastroenterology
    JF  - International Journal of Gastroenterology
    JO  - International Journal of Gastroenterology
    SP  - 15
    EP  - 24
    PB  - Science Publishing Group
    SN  - 2640-169X
    UR  - https://doi.org/10.11648/j.ijg.20250901.13
    AB  - Background of the Study: Upper Gastrointestinal bleeding (UGIB) remains to be a significant clinical concern for geriatric patients due to their prolonged hospital stay and higher mortality and morbidity rates. The clinical profile of the geriatric patients are important aspects to consider, given that there is limited data in elderly population. Objective: The study is aimed to determine the clinical profile of elderly patients with UGIB admitted in a Tertiary Hospital from January 2024 to June 2024. Methods: This is a retrospective cohort study among elderly Filipino patients aged 60 years and above; admitted as UGIB and underwent esophagogastroduodenoscopy (EGD). Baseline Demographic, clinical presentation, laboratory results, endoscopic findings, prognosis and predictors of mortality were evaluated. Statistical analysis involved the application of Pearson’s chi-square, Fisher’s exact test, T-test and univariate and multivariate logistic regression analysis. Results: Among 102 admitted elderly patients with UGIB, 67 of them underwent EGD, thus were included in the study; 43 (64.18%) were male and 24 (35.82%) were female with the median age of 69.66 (±7.40) years. The prevalence rate of UGIB among elderly Filipino is 8.90%. 50 of those patients (74.63%) had comorbidities, the most common were: hypertension 38 (56.72%), diabetes mellitus 19 (28.36%) and chronic kidney diseases (13.43%). Patients presented mostly with melena (67.16%), generalized body weakness (53.73%) and 19.40% had abdominal pain. During endoscopy, (47.76%) was due to gastritis and gastric ulcer (19.40%). Mortality rate was higher in patients admitted at the ICU. No association was noted between the patients’ mortality and their sex, age, comorbidities, medications used, clinical findings, INR, BUN, hemoglobin, blood transfusion, and endoscopic findings. Conclusion: The present study reported that elderly patients with UGIB were male, with hypertension as the most common comorbidity. EGD findings showed gastritis as the most common cause of UGIB. Mortality rate is higher in patients admitted at the ICU. None of the variables showed significant differences in terms of predictors of mortality.
    
    VL  - 9
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Sections