Background/Objective: D-dimer, a soluble fibrin degradation product, is used to be a marker of vascular thrombosis. However, it has been reported to be elevated in different pathological conditions other than thrombosis. Moreover, its pattern post-liver transplantation (LT) in children is not known. So, we aimed to report its pattern within the first-month post-LT in children and its level in different early post-LT complications. Methods: It is a retrospective observational cohort study in which 52 children who underwent living-related liver transplantation (LRLT) were included. All the available clinical, imaging, and laboratory data including D-dimer level were collected from the patients' files. Those who developed complications within the first post-LT month were assigned to the complication group (n=41), and others were assigned to the non-complication group (n=11). Results: D-dimer level pre-LT ranged from 0.12-16.41 mg/l, with no significant difference between the complication and non-complication groups. Postoperatively, the D-dimer levels were elevated and did not normalize till the postoperative day (POD) 30. The minimum reported level was 1.2 mg/l on POD0 while the maximum one was 33.12 mg/l on POD12. There were no significant differences between the complication and non-complication groups about the D-dimer level from the pre-LT day till the POD30 (p>0.05). The D-dimer level at the onset of the different complications showed no significant difference among the thrombotic, ACR, and the other complication subgroups (p=0.748). Moreover, the vascular thrombosis subgroup didn’t show a significant difference between the D-dimer level before- and at the onset of thrombosis (p=0.480). Conclusion: D-dimer is non-specifically elevated within the 1st-month post-LRLT in children with no clear trend. Moreover, it doesn’t normalize till the end of the 1st post-LT month. Being high early postoperatively doesn't necessarily indicate vascular thrombosis or other complications but rather the nature of the transplantation circumstances.
| Published in | International Journal of Gastroenterology (Volume 8, Issue 1) |
| DOI | 10.11648/j.ijg.20240801.15 |
| Page(s) | 22-31 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Acute Cellular Rejection, Children, D-Dimer, Living-Related Liver Transplantation, Post-Liver Transplantation Complications, Vascular Thrombosis
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APA Style
Darwish, H. S., Adawy, N. M., Saber, M. A., Radwan, N. M. (2024). D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children. International Journal of Gastroenterology, 8(1), 22-31. https://doi.org/10.11648/j.ijg.20240801.15
ACS Style
Darwish, H. S.; Adawy, N. M.; Saber, M. A.; Radwan, N. M. D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children. Int. J. Gastroenterol. 2024, 8(1), 22-31. doi: 10.11648/j.ijg.20240801.15
AMA Style
Darwish HS, Adawy NM, Saber MA, Radwan NM. D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children. Int J Gastroenterol. 2024;8(1):22-31. doi: 10.11648/j.ijg.20240801.15
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Download@article{10.11648/j.ijg.20240801.15,
author = {Hadil Samir Darwish and Nermin Mohamed Adawy and Magdy Anwar Saber and Noha Mohamed Radwan},
title = {D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children
},
journal = {International Journal of Gastroenterology},
volume = {8},
number = {1},
pages = {22-31},
doi = {10.11648/j.ijg.20240801.15},
url = {https://doi.org/10.11648/j.ijg.20240801.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20240801.15},
abstract = {Background/Objective: D-dimer, a soluble fibrin degradation product, is used to be a marker of vascular thrombosis. However, it has been reported to be elevated in different pathological conditions other than thrombosis. Moreover, its pattern post-liver transplantation (LT) in children is not known. So, we aimed to report its pattern within the first-month post-LT in children and its level in different early post-LT complications. Methods: It is a retrospective observational cohort study in which 52 children who underwent living-related liver transplantation (LRLT) were included. All the available clinical, imaging, and laboratory data including D-dimer level were collected from the patients' files. Those who developed complications within the first post-LT month were assigned to the complication group (n=41), and others were assigned to the non-complication group (n=11). Results: D-dimer level pre-LT ranged from 0.12-16.41 mg/l, with no significant difference between the complication and non-complication groups. Postoperatively, the D-dimer levels were elevated and did not normalize till the postoperative day (POD) 30. The minimum reported level was 1.2 mg/l on POD0 while the maximum one was 33.12 mg/l on POD12. There were no significant differences between the complication and non-complication groups about the D-dimer level from the pre-LT day till the POD30 (p>0.05). The D-dimer level at the onset of the different complications showed no significant difference among the thrombotic, ACR, and the other complication subgroups (p=0.748). Moreover, the vascular thrombosis subgroup didn’t show a significant difference between the D-dimer level before- and at the onset of thrombosis (p=0.480). Conclusion: D-dimer is non-specifically elevated within the 1st-month post-LRLT in children with no clear trend. Moreover, it doesn’t normalize till the end of the 1st post-LT month. Being high early postoperatively doesn't necessarily indicate vascular thrombosis or other complications but rather the nature of the transplantation circumstances.
},
year = {2024}
}
TY - JOUR T1 - D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children AU - Hadil Samir Darwish AU - Nermin Mohamed Adawy AU - Magdy Anwar Saber AU - Noha Mohamed Radwan Y1 - 2024/05/17 PY - 2024 N1 - https://doi.org/10.11648/j.ijg.20240801.15 DO - 10.11648/j.ijg.20240801.15 T2 - International Journal of Gastroenterology JF - International Journal of Gastroenterology JO - International Journal of Gastroenterology SP - 22 EP - 31 PB - Science Publishing Group SN - 2640-169X UR - https://doi.org/10.11648/j.ijg.20240801.15 AB - Background/Objective: D-dimer, a soluble fibrin degradation product, is used to be a marker of vascular thrombosis. However, it has been reported to be elevated in different pathological conditions other than thrombosis. Moreover, its pattern post-liver transplantation (LT) in children is not known. So, we aimed to report its pattern within the first-month post-LT in children and its level in different early post-LT complications. Methods: It is a retrospective observational cohort study in which 52 children who underwent living-related liver transplantation (LRLT) were included. All the available clinical, imaging, and laboratory data including D-dimer level were collected from the patients' files. Those who developed complications within the first post-LT month were assigned to the complication group (n=41), and others were assigned to the non-complication group (n=11). Results: D-dimer level pre-LT ranged from 0.12-16.41 mg/l, with no significant difference between the complication and non-complication groups. Postoperatively, the D-dimer levels were elevated and did not normalize till the postoperative day (POD) 30. The minimum reported level was 1.2 mg/l on POD0 while the maximum one was 33.12 mg/l on POD12. There were no significant differences between the complication and non-complication groups about the D-dimer level from the pre-LT day till the POD30 (p>0.05). The D-dimer level at the onset of the different complications showed no significant difference among the thrombotic, ACR, and the other complication subgroups (p=0.748). Moreover, the vascular thrombosis subgroup didn’t show a significant difference between the D-dimer level before- and at the onset of thrombosis (p=0.480). Conclusion: D-dimer is non-specifically elevated within the 1st-month post-LRLT in children with no clear trend. Moreover, it doesn’t normalize till the end of the 1st post-LT month. Being high early postoperatively doesn't necessarily indicate vascular thrombosis or other complications but rather the nature of the transplantation circumstances. VL - 8 IS - 1 ER -
Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom, Egypt
Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom, Egypt
Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom, Egypt
Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom, Egypt
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