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Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa

Received: 6 August 2023     Accepted: 29 August 2023     Published: 6 September 2023
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Abstract

Objective: The overall aim of this study was to determine the impact of nutrition education on the tolerance and response to chemotherapy of cancer patients at Douala General Hospital. Material and methods: This was a 2-arm randomized comparative study done over a 5-months period from November 1, 2016 to March 31, 2017. A total of 107 patients with all cancers undergoing chemotherapy were randomized into 2 groups after obtaining their informed consent: the group that received nutrition education with each cycle of chemotherapy, and the group without nutrition education that received only the usual treatment. Results: The mean age was 46.6 ±15.3 years. The most common cancers were breast cancer (36.4%) and cervical cancer (19.4%). The incidence of undernutrition in our study population was 45.8%, of which 35.5% was moderate and 10.3% severe. Patients in the nutrition education group showed a marked improvement in their nutritional status after 3 cycles of chemotherapy, tolerated the treatment better and had a better response to it. Conversely, patients in the group without nutritional education showed a deterioration in their nutritional status, tolerated treatment less and also responded less to it. Moreover, in the latter group, the risk of not responding to treatment was 19.6 times greater than in patients who received nutritional follow-up. Conclusion: Nutritional education had a significant impact on patients' nutritional status, tolerance and response to chemotherapy.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 8, Issue 3)
DOI 10.11648/j.ijcocr.20230803.12
Page(s) 46-56
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Nutritional Education, Nutritional Status, Chemotherapy, Tolerance, Response

References
[1] Pressoir M, Desné S, Berchery D, Rossignol G, Poiree B, Meslier M, et al. Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres. Br J Cancer. 2010; 102 (6): 966-71.
[2] Ollenschlager G, Viell B, Thomas W, Konkol K, Burger B. tumor anorexia: causes, assessment, treatment. 1991; 121: 249-59.
[3] Senesse P, Latino Martel P. Nutrition in the adult cancer patient. France; 2013 p. 23.
[4] Cédric Adengoyo, Iliassou Ndam, Rose Mediebou Tchindji, Moïse Moupou. Agricultural colonization of forest areas in MBAM and KIM MERIDIONAL (Centre-Cameroon): Acteurs et processus culturaux. Revue Espace géographique et Société Marocaine. 2023; 71: 49-73.
[5] Swiss Embassy in the Republic of Cameroon. Economic Report 2022 Republic of Cameroon. [online] 2022. [cited May 06, 2023] Available from: file:///C:/Users/User/Downloads/CM%20Rapport%20%C3%A9conomique%202022%20Cameroun%20publique.pdf
[6] Picot J, Cooper K, Bryant J, Clegg AJ. Karnofsky performance status and WHO performance status scores. NIHR journal Library [Internet]. United Kingdom; 2011 [cited 2017 Jun 11]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK97482/
[7] Ravasco P, Monteiro-Grillo I, Camilo M. Individualized nutrition intervention is of major benefit to colorectal cancer patients: long-term follow-up of a randomized controlled trial of nutritional therapy. Am J Clin Nutr. 2012; 96 (6): 1346-53.
[8] Fournier L, Thiam R, Frija G. RECIST 1.1: instructions for use. Cancéro Dig. 2011; 3 (1): 27-28.
[9] Keisuke Maeda, Yuria Ishida, Tomoyuki Nonogaki, Naoharu Mori. Reference body mass index values and the prevalence of malnutrition according to the Global Leadership Initiative on Malnutrition criteria. Clinical Nutrition. 2020; 39: 180 -184.
[10] Shirodkar M, Mohandas KM. Subjective global assessment: a simple and reliable screening tool for malnutrition among Indians. Indian J Gastroenterol Off J Indian Soc Gastroenterol. 2005; 24 (6): 246-50.
[11] National Cancer Control Institute. Cancer Therapy evaluation Programme. Common Toxicity Criteria Manual. [online]. 1999. [cited Aug 05, 2023]. Available from: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcmanual_v4_10-4-99.pdf [Internet]
[12] Wu BW, Yin T, Cao WX, Gu ZD, Wang XJ, Yan M, et al. Clinical application of subjective global assessment in Chinese patients with gastrointestinal cancer. World J Gastroenterol. 2009; 15 (28): 3542-9.
[13] Mazières J. Denutrition and cancer. INSERM; 2012.
[14] Hebuterne X. Prise en charge nutritionnelle des malades atteints d'un cancer digestif. 2009; Paris.
[15] Isenring EA, Capra S, Bauer JD. Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area. Br J Cancer. 2004; 91 (3): 447-52.
[16] Bauer JD, Capra S. Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy?a pilot study. Support Care Cancer. 2005; 13 (4): 270-4.
[17] Hébuterne X, Lemarié E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F. Prevalence of Malnutrition and Current Use of Nutrition Support in Patients With Cancer. J Parenter Enter Nutr. Feb 2014; 38 (2): 196-204.
[18] Duee P, Gerber M, Latino Martel M, Latruffe N, Pecollo N. Nutrition and cancer: Legitimacy of nutritional recommendations in cancer prevention. 2011e ed. ANSES; 2011. 75 p.
[19] May Levin F, Rossignol G, Simon M. Alimentation et cancer Comment s'alimenter pendant les traitements? France: La ligue contre le cancer; 2010. 27 p.
[20] Nayel H, El Ghoneimy E, El Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. 1992 [cited 2017 May 22]; 1 (8). Available from: https://www.ncbi.nlm.nih.gov/pubmed/1562782
[21] Brahmi SA, Zahra ZF, Seddik Y, Afqir S. The problem of the cost of new therapeutics in oncology: what about Morocco? Pan African Medical Journal. 2016; 24: 51.
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  • APA Style

    Dina Bell Esther Hortense Murielle, Esson Mapoko Berthe, Sango Anne, Atenguena Etienne, Maïson Mayeh, et al. (2023). Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa. International Journal of Clinical Oncology and Cancer Research, 8(3), 46-56. https://doi.org/10.11648/j.ijcocr.20230803.12

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    ACS Style

    Dina Bell Esther Hortense Murielle; Esson Mapoko Berthe; Sango Anne; Atenguena Etienne; Maïson Mayeh, et al. Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa. Int. J. Clin. Oncol. Cancer Res. 2023, 8(3), 46-56. doi: 10.11648/j.ijcocr.20230803.12

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    AMA Style

    Dina Bell Esther Hortense Murielle, Esson Mapoko Berthe, Sango Anne, Atenguena Etienne, Maïson Mayeh, et al. Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa. Int J Clin Oncol Cancer Res. 2023;8(3):46-56. doi: 10.11648/j.ijcocr.20230803.12

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  • @article{10.11648/j.ijcocr.20230803.12,
      author = {Dina Bell Esther Hortense Murielle and Esson Mapoko Berthe and Sango Anne and Atenguena Etienne and Maïson Mayeh and Mekah Mapenya and Ndangue Ntone Nancy and Anaba Dominique and Ntama Ambroise and Aminatou Ada and Mbemmo Murielle Laure and Ngo Bikond Grace and Yondo Edimo Suzanne and Mouelle Mbassi W and Mouelle Michel and Tchakounté Boris and Ananga Noa and Mananga Jean Charles and Hilaire Mbiatat and Njock Louis Richard},
      title = {Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {8},
      number = {3},
      pages = {46-56},
      doi = {10.11648/j.ijcocr.20230803.12},
      url = {https://doi.org/10.11648/j.ijcocr.20230803.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20230803.12},
      abstract = {Objective: The overall aim of this study was to determine the impact of nutrition education on the tolerance and response to chemotherapy of cancer patients at Douala General Hospital. Material and methods: This was a 2-arm randomized comparative study done over a 5-months period from November 1, 2016 to March 31, 2017. A total of 107 patients with all cancers undergoing chemotherapy were randomized into 2 groups after obtaining their informed consent: the group that received nutrition education with each cycle of chemotherapy, and the group without nutrition education that received only the usual treatment. Results: The mean age was 46.6 ±15.3 years. The most common cancers were breast cancer (36.4%) and cervical cancer (19.4%). The incidence of undernutrition in our study population was 45.8%, of which 35.5% was moderate and 10.3% severe. Patients in the nutrition education group showed a marked improvement in their nutritional status after 3 cycles of chemotherapy, tolerated the treatment better and had a better response to it. Conversely, patients in the group without nutritional education showed a deterioration in their nutritional status, tolerated treatment less and also responded less to it. Moreover, in the latter group, the risk of not responding to treatment was 19.6 times greater than in patients who received nutritional follow-up. Conclusion: Nutritional education had a significant impact on patients' nutritional status, tolerance and response to chemotherapy.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Impact of Nutrition Education on Nutritional Status, Tolerance and Response to Chemotherapy: Experience at Douala General Hospital, Cameroon, Central Africa
    AU  - Dina Bell Esther Hortense Murielle
    AU  - Esson Mapoko Berthe
    AU  - Sango Anne
    AU  - Atenguena Etienne
    AU  - Maïson Mayeh
    AU  - Mekah Mapenya
    AU  - Ndangue Ntone Nancy
    AU  - Anaba Dominique
    AU  - Ntama Ambroise
    AU  - Aminatou Ada
    AU  - Mbemmo Murielle Laure
    AU  - Ngo Bikond Grace
    AU  - Yondo Edimo Suzanne
    AU  - Mouelle Mbassi W
    AU  - Mouelle Michel
    AU  - Tchakounté Boris
    AU  - Ananga Noa
    AU  - Mananga Jean Charles
    AU  - Hilaire Mbiatat
    AU  - Njock Louis Richard
    Y1  - 2023/09/06
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijcocr.20230803.12
    DO  - 10.11648/j.ijcocr.20230803.12
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 46
    EP  - 56
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20230803.12
    AB  - Objective: The overall aim of this study was to determine the impact of nutrition education on the tolerance and response to chemotherapy of cancer patients at Douala General Hospital. Material and methods: This was a 2-arm randomized comparative study done over a 5-months period from November 1, 2016 to March 31, 2017. A total of 107 patients with all cancers undergoing chemotherapy were randomized into 2 groups after obtaining their informed consent: the group that received nutrition education with each cycle of chemotherapy, and the group without nutrition education that received only the usual treatment. Results: The mean age was 46.6 ±15.3 years. The most common cancers were breast cancer (36.4%) and cervical cancer (19.4%). The incidence of undernutrition in our study population was 45.8%, of which 35.5% was moderate and 10.3% severe. Patients in the nutrition education group showed a marked improvement in their nutritional status after 3 cycles of chemotherapy, tolerated the treatment better and had a better response to it. Conversely, patients in the group without nutritional education showed a deterioration in their nutritional status, tolerated treatment less and also responded less to it. Moreover, in the latter group, the risk of not responding to treatment was 19.6 times greater than in patients who received nutritional follow-up. Conclusion: Nutritional education had a significant impact on patients' nutritional status, tolerance and response to chemotherapy.
    VL  - 8
    IS  - 3
    ER  - 

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Author Information
  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Internal Medicine and Specialities, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon

  • Department of Internal Medicine and Paediatric Faculty of Health Sciences, University of Buea, Buea, Cameroon

  • Department of Internal Medicine and Specialities, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Internal Medicine and Specialities, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon

  • Department of Oncology, Laquintinie Hospital, Douala, Cameroon

  • Department of Internal Medicine and Paediatric Faculty of Health Sciences, University of Buea, Buea, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Oncology, Douala General Hospital, Douala, Cameroon

  • Department of Oncology, Douala General Hospital, Douala, Cameroon

  • Department of Internal Medicine, Oncology Unit, Douala Gynaeco-Obstetric and Paediatric Hospital, Douala, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Oncology Yaoundé Gynaeco-Obstetric and Paediatric Hospital, Yaoundé, Cameroon

  • General Secretary, Ministry of Public Health, Yaoundé, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Department of Oncology, Douala General Hospital, Douala, Cameroon

  • Department of Oncology, Douala General Hospital, Douala, Cameroon

  • Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

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