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Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer

Received: 21 February 2023     Accepted: 13 March 2023     Published: 10 May 2023
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Abstract

Background: Lung cancer kills the most people worldwide. Most Bangladeshi patients had regionally advanced surgically inoperable Non-Small Cell Lung Cancer (NSCLC), a deadly disease. Radiotherapy to main tumor and regional lymphatics with chemotherapy is conventional treatment. Objective: This study was done to investigate the symptoms relief and treatment related toxicities in hypo fractionated 17 Gy in 2 fractions which is effectively comparable to 30 Gy in 10 fractions. Methods: A total 60 patients were divided equally into Arm A and Arm B with locally advanced stage IIIA, and stage IIIB NSCLC patients with the objective to compare palliation of symptoms and to assess the toxicity profile. This Quasi Experimental study was carried out from January 2018 to December 2018 in the department of Radiation oncology, National Institute of Cancer Research and Hospital. Cases of Arm A were treated with 17 Gy radiotherapy in 2 fractions and those of Arm B were treated with 30 Gy radiotherapy in 10 fractions. Results: The mean age was 49.3±8.8 and 52.2±8.1 years for the Arm- A and the Arm-B respectively. Most patients in both groups were males, 80% in group A and 90% in group B. Adenocarcinoma (Arm A-70%, Arm B- 66.7%) was the most common pathological subtype in both groups, followed by Squamous cell carcinoma (30%, 33.3% respectively). This study showed that there was a significant palliation of these symptoms following radiotherapy as reported by patients and as assessed clinically with no statistically significant difference between two Arms. Hemoptysis had the highest rate of improvement, 100% in both arms and improvement in chest pain by 83.3% in arm A and 70% in Arm B. Cough was improved in 83.3% and 67.7% and dyspnea was palliated in 80.0% and 70.0% of patients in Arm A and Arm B, respectively as per clinical assessment of the patients. The early toxicities in both arms had no significant difference. Patients with locally advanced inoperable NSCLC have poor prognosis and less survival. The first goal was acceptable symptoms control as cough, dyspnoea, haemoptysis and chest pain. Conclusion: The result of this study showed that a significant palliation of symptoms with minimum toxicities improving quality of life following radiotherapy as reported by patients also assessed clinically and radiographically with no statistically significant difference among both arms.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 8, Issue 2)
DOI 10.11648/j.ijcocr.20230802.11
Page(s) 20-26
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Hypofractionated Palliative Radiotherapy, Lung Cancer, Toxicities

References
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[3] Pfister, D. G., Johnson, D. H., Azzoli, C. G., Sause, W., Smith, T. J., Baker Jr, S. et al., 2004. American Society of Clinical Oncology treatment of unresectable non–small-cell lung cancer guideline: Update 2003. Journal of Clinical Oncology, 22 (2), pp. 330-353.
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[15] ASRTO 2016 : Hypofractionated radiation therapy may halve treatment time for lung cancer patient with poor performance status.
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[17] Senkus-Konefka, E., Dziadziuszko, R., Bednaruk-Młyński, E., Pliszka, A., Kubrak, J., Lewandowska, A., et al., 2005. A prospective, randomised study to compare two palliative radiotherapy schedules for non-small-cell lung cancer (NSCLC). British journal of cancer, 92 (6), pp. 1038–1045.
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  • APA Style

    Kamrun Nahar Tania, Jannatun Nisa, Moarraf Hossen, Muhammad Masudul Hassan Arup, Muhammad Abdullah-Al-Noman, et al. (2023). Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer. International Journal of Clinical Oncology and Cancer Research, 8(2), 20-26. https://doi.org/10.11648/j.ijcocr.20230802.11

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    ACS Style

    Kamrun Nahar Tania; Jannatun Nisa; Moarraf Hossen; Muhammad Masudul Hassan Arup; Muhammad Abdullah-Al-Noman, et al. Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer. Int. J. Clin. Oncol. Cancer Res. 2023, 8(2), 20-26. doi: 10.11648/j.ijcocr.20230802.11

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    AMA Style

    Kamrun Nahar Tania, Jannatun Nisa, Moarraf Hossen, Muhammad Masudul Hassan Arup, Muhammad Abdullah-Al-Noman, et al. Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer. Int J Clin Oncol Cancer Res. 2023;8(2):20-26. doi: 10.11648/j.ijcocr.20230802.11

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  • @article{10.11648/j.ijcocr.20230802.11,
      author = {Kamrun Nahar Tania and Jannatun Nisa and Moarraf Hossen and Muhammad Masudul Hassan Arup and Muhammad Abdullah-Al-Noman and Mohammad Shaiful Hassan Shameem and Sonya Begum and Mohammad Arifur Rahman},
      title = {Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {8},
      number = {2},
      pages = {20-26},
      doi = {10.11648/j.ijcocr.20230802.11},
      url = {https://doi.org/10.11648/j.ijcocr.20230802.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20230802.11},
      abstract = {Background: Lung cancer kills the most people worldwide. Most Bangladeshi patients had regionally advanced surgically inoperable Non-Small Cell Lung Cancer (NSCLC), a deadly disease. Radiotherapy to main tumor and regional lymphatics with chemotherapy is conventional treatment. Objective: This study was done to investigate the symptoms relief and treatment related toxicities in hypo fractionated 17 Gy in 2 fractions which is effectively comparable to 30 Gy in 10 fractions. Methods: A total 60 patients were divided equally into Arm A and Arm B with locally advanced stage IIIA, and stage IIIB NSCLC patients with the objective to compare palliation of symptoms and to assess the toxicity profile. This Quasi Experimental study was carried out from January 2018 to December 2018 in the department of Radiation oncology, National Institute of Cancer Research and Hospital. Cases of Arm A were treated with 17 Gy radiotherapy in 2 fractions and those of Arm B were treated with 30 Gy radiotherapy in 10 fractions. Results: The mean age was 49.3±8.8 and 52.2±8.1 years for the Arm- A and the Arm-B respectively. Most patients in both groups were males, 80% in group A and 90% in group B. Adenocarcinoma (Arm A-70%, Arm B- 66.7%) was the most common pathological subtype in both groups, followed by Squamous cell carcinoma (30%, 33.3% respectively). This study showed that there was a significant palliation of these symptoms following radiotherapy as reported by patients and as assessed clinically with no statistically significant difference between two Arms. Hemoptysis had the highest rate of improvement, 100% in both arms and improvement in chest pain by 83.3% in arm A and 70% in Arm B. Cough was improved in 83.3% and 67.7% and dyspnea was palliated in 80.0% and 70.0% of patients in Arm A and Arm B, respectively as per clinical assessment of the patients. The early toxicities in both arms had no significant difference. Patients with locally advanced inoperable NSCLC have poor prognosis and less survival. The first goal was acceptable symptoms control as cough, dyspnoea, haemoptysis and chest pain. Conclusion: The result of this study showed that a significant palliation of symptoms with minimum toxicities improving quality of life following radiotherapy as reported by patients also assessed clinically and radiographically with no statistically significant difference among both arms.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer
    AU  - Kamrun Nahar Tania
    AU  - Jannatun Nisa
    AU  - Moarraf Hossen
    AU  - Muhammad Masudul Hassan Arup
    AU  - Muhammad Abdullah-Al-Noman
    AU  - Mohammad Shaiful Hassan Shameem
    AU  - Sonya Begum
    AU  - Mohammad Arifur Rahman
    Y1  - 2023/05/10
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijcocr.20230802.11
    DO  - 10.11648/j.ijcocr.20230802.11
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 20
    EP  - 26
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20230802.11
    AB  - Background: Lung cancer kills the most people worldwide. Most Bangladeshi patients had regionally advanced surgically inoperable Non-Small Cell Lung Cancer (NSCLC), a deadly disease. Radiotherapy to main tumor and regional lymphatics with chemotherapy is conventional treatment. Objective: This study was done to investigate the symptoms relief and treatment related toxicities in hypo fractionated 17 Gy in 2 fractions which is effectively comparable to 30 Gy in 10 fractions. Methods: A total 60 patients were divided equally into Arm A and Arm B with locally advanced stage IIIA, and stage IIIB NSCLC patients with the objective to compare palliation of symptoms and to assess the toxicity profile. This Quasi Experimental study was carried out from January 2018 to December 2018 in the department of Radiation oncology, National Institute of Cancer Research and Hospital. Cases of Arm A were treated with 17 Gy radiotherapy in 2 fractions and those of Arm B were treated with 30 Gy radiotherapy in 10 fractions. Results: The mean age was 49.3±8.8 and 52.2±8.1 years for the Arm- A and the Arm-B respectively. Most patients in both groups were males, 80% in group A and 90% in group B. Adenocarcinoma (Arm A-70%, Arm B- 66.7%) was the most common pathological subtype in both groups, followed by Squamous cell carcinoma (30%, 33.3% respectively). This study showed that there was a significant palliation of these symptoms following radiotherapy as reported by patients and as assessed clinically with no statistically significant difference between two Arms. Hemoptysis had the highest rate of improvement, 100% in both arms and improvement in chest pain by 83.3% in arm A and 70% in Arm B. Cough was improved in 83.3% and 67.7% and dyspnea was palliated in 80.0% and 70.0% of patients in Arm A and Arm B, respectively as per clinical assessment of the patients. The early toxicities in both arms had no significant difference. Patients with locally advanced inoperable NSCLC have poor prognosis and less survival. The first goal was acceptable symptoms control as cough, dyspnoea, haemoptysis and chest pain. Conclusion: The result of this study showed that a significant palliation of symptoms with minimum toxicities improving quality of life following radiotherapy as reported by patients also assessed clinically and radiographically with no statistically significant difference among both arms.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, Chittagong Medical College Hospital, Chittagong, Bangladesh

  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, Delta Hospital, Dhaka, Bangladesh

  • Department of Radiation Oncology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

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