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Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo

Received: 9 June 2021     Accepted: 26 June 2021     Published: 19 October 2021
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Abstract

Background: Human Papillomavirus (HPV) infection is the most common sexually transmitted infection in the world, particularly affecting people living with human immunodeficiency virus (HIV). A synergy between the two viruses is however described by several authors but very little is known in women living with HIV-HPV co-infection in Lubumbashi in the South of the Democratic Republic of Congo (DRC). Objective: The purpose of this study was to determine the prevalence of HPV infection in women living with HIV, to define the socio-demographic profile of HPV infection and to analyze certain clinical and paraclinical parameters. Methodology: A total of 77 women, including 58 HIV-infected women (group 1) and 19 HIV-free women (group 2), were included in a cross-sectional descriptive study that was conducted from November 01 to 30, 2019 at the HIV-AIDS Mother-Child Transmission Prevention Unit (MCTPU) of the Lubumbashi University Clinics (LUC). HPV was tested on cervical-vaginal secretions obtained either by self-sampling or by a sample taken by a previously trained examiner. HPV was investigated by the INNO-LIPA (PCR) method at the Microbiology, Bioorganic Chemistry and Macromolecular Unit laboratory of the Free University of Brussels in Belgium (FUB) while the diagnosis of HIV infection (PCR), viral load determination and CD4 level assay was performed in the LUC laboratory. Results: The overall frequency of HPV infection was 74.03%. It was significantly higher in HIV-infected women than in non-HIV-infected women (81.08% vs. 52.63%). The socio-demographic profile of the HPV-infected patient was made up of predominantly married, multi-parented women, aged on average 35, with a secondary education level and an average socio-economic level. Low monthly incomes and HIV infection were almost 4 times at risk for HPV infection (OR 4.2 [1,439-12,262] and OR 3.75 [1,269-11,080] respectively). Finally, HIV-positive patients infected with HPV had overall low levels of Lymphocyte T CD4 compared to those not infected with HPV. Conclusion: Our study shows that in Lubumbashi, HPV infection is present in both HIV-positive and negative women but its prevalence is distinctly higher in HIV-positive patients than those without HIV infection. It is interesting to determine in subsequent studies the different genotypes of HPV circulating in Lubumbashi and to define the proportion of genotypes at high carcinogenic risk.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 6, Issue 4)
DOI 10.11648/j.ijcocr.20210604.11
Page(s) 145-150
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Human Papillomavirus, HIV, Lubumbashi

References
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Cite This Article
  • APA Style

    Munkana Ndundula Arthur, Isango Idi Yves, Kasonga Kasonga Michel, Mushemuka Baleke Christian, Kasamba Ilunga Eric, et al. (2021). Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo. International Journal of Clinical Oncology and Cancer Research, 6(4), 145-150. https://doi.org/10.11648/j.ijcocr.20210604.11

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    ACS Style

    Munkana Ndundula Arthur; Isango Idi Yves; Kasonga Kasonga Michel; Mushemuka Baleke Christian; Kasamba Ilunga Eric, et al. Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo. Int. J. Clin. Oncol. Cancer Res. 2021, 6(4), 145-150. doi: 10.11648/j.ijcocr.20210604.11

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    AMA Style

    Munkana Ndundula Arthur, Isango Idi Yves, Kasonga Kasonga Michel, Mushemuka Baleke Christian, Kasamba Ilunga Eric, et al. Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo. Int J Clin Oncol Cancer Res. 2021;6(4):145-150. doi: 10.11648/j.ijcocr.20210604.11

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  • @article{10.11648/j.ijcocr.20210604.11,
      author = {Munkana Ndundula Arthur and Isango Idi Yves and Kasonga Kasonga Michel and Mushemuka Baleke Christian and Kasamba Ilunga Eric and Mwamba Mulumba Claude and Bakamwimba Kamwina Boaz and Tamubango Kitoko Hermann and Kakoma Sakatolo Zambèze and Fontaine Véronique and Kalenga Muenze Kayamba Prosper},
      title = {Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {6},
      number = {4},
      pages = {145-150},
      doi = {10.11648/j.ijcocr.20210604.11},
      url = {https://doi.org/10.11648/j.ijcocr.20210604.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20210604.11},
      abstract = {Background: Human Papillomavirus (HPV) infection is the most common sexually transmitted infection in the world, particularly affecting people living with human immunodeficiency virus (HIV). A synergy between the two viruses is however described by several authors but very little is known in women living with HIV-HPV co-infection in Lubumbashi in the South of the Democratic Republic of Congo (DRC). Objective: The purpose of this study was to determine the prevalence of HPV infection in women living with HIV, to define the socio-demographic profile of HPV infection and to analyze certain clinical and paraclinical parameters. Methodology: A total of 77 women, including 58 HIV-infected women (group 1) and 19 HIV-free women (group 2), were included in a cross-sectional descriptive study that was conducted from November 01 to 30, 2019 at the HIV-AIDS Mother-Child Transmission Prevention Unit (MCTPU) of the Lubumbashi University Clinics (LUC). HPV was tested on cervical-vaginal secretions obtained either by self-sampling or by a sample taken by a previously trained examiner. HPV was investigated by the INNO-LIPA (PCR) method at the Microbiology, Bioorganic Chemistry and Macromolecular Unit laboratory of the Free University of Brussels in Belgium (FUB) while the diagnosis of HIV infection (PCR), viral load determination and CD4 level assay was performed in the LUC laboratory. Results: The overall frequency of HPV infection was 74.03%. It was significantly higher in HIV-infected women than in non-HIV-infected women (81.08% vs. 52.63%). The socio-demographic profile of the HPV-infected patient was made up of predominantly married, multi-parented women, aged on average 35, with a secondary education level and an average socio-economic level. Low monthly incomes and HIV infection were almost 4 times at risk for HPV infection (OR 4.2 [1,439-12,262] and OR 3.75 [1,269-11,080] respectively). Finally, HIV-positive patients infected with HPV had overall low levels of Lymphocyte T CD4 compared to those not infected with HPV. Conclusion: Our study shows that in Lubumbashi, HPV infection is present in both HIV-positive and negative women but its prevalence is distinctly higher in HIV-positive patients than those without HIV infection. It is interesting to determine in subsequent studies the different genotypes of HPV circulating in Lubumbashi and to define the proportion of genotypes at high carcinogenic risk.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Human Papillomavirus Infection Among HIV-positive Women in Lubumbashi, Democratic Republic of the Congo
    AU  - Munkana Ndundula Arthur
    AU  - Isango Idi Yves
    AU  - Kasonga Kasonga Michel
    AU  - Mushemuka Baleke Christian
    AU  - Kasamba Ilunga Eric
    AU  - Mwamba Mulumba Claude
    AU  - Bakamwimba Kamwina Boaz
    AU  - Tamubango Kitoko Hermann
    AU  - Kakoma Sakatolo Zambèze
    AU  - Fontaine Véronique
    AU  - Kalenga Muenze Kayamba Prosper
    Y1  - 2021/10/19
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijcocr.20210604.11
    DO  - 10.11648/j.ijcocr.20210604.11
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 145
    EP  - 150
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20210604.11
    AB  - Background: Human Papillomavirus (HPV) infection is the most common sexually transmitted infection in the world, particularly affecting people living with human immunodeficiency virus (HIV). A synergy between the two viruses is however described by several authors but very little is known in women living with HIV-HPV co-infection in Lubumbashi in the South of the Democratic Republic of Congo (DRC). Objective: The purpose of this study was to determine the prevalence of HPV infection in women living with HIV, to define the socio-demographic profile of HPV infection and to analyze certain clinical and paraclinical parameters. Methodology: A total of 77 women, including 58 HIV-infected women (group 1) and 19 HIV-free women (group 2), were included in a cross-sectional descriptive study that was conducted from November 01 to 30, 2019 at the HIV-AIDS Mother-Child Transmission Prevention Unit (MCTPU) of the Lubumbashi University Clinics (LUC). HPV was tested on cervical-vaginal secretions obtained either by self-sampling or by a sample taken by a previously trained examiner. HPV was investigated by the INNO-LIPA (PCR) method at the Microbiology, Bioorganic Chemistry and Macromolecular Unit laboratory of the Free University of Brussels in Belgium (FUB) while the diagnosis of HIV infection (PCR), viral load determination and CD4 level assay was performed in the LUC laboratory. Results: The overall frequency of HPV infection was 74.03%. It was significantly higher in HIV-infected women than in non-HIV-infected women (81.08% vs. 52.63%). The socio-demographic profile of the HPV-infected patient was made up of predominantly married, multi-parented women, aged on average 35, with a secondary education level and an average socio-economic level. Low monthly incomes and HIV infection were almost 4 times at risk for HPV infection (OR 4.2 [1,439-12,262] and OR 3.75 [1,269-11,080] respectively). Finally, HIV-positive patients infected with HPV had overall low levels of Lymphocyte T CD4 compared to those not infected with HPV. Conclusion: Our study shows that in Lubumbashi, HPV infection is present in both HIV-positive and negative women but its prevalence is distinctly higher in HIV-positive patients than those without HIV infection. It is interesting to determine in subsequent studies the different genotypes of HPV circulating in Lubumbashi and to define the proportion of genotypes at high carcinogenic risk.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Biomedical Sciences, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Internal Medicine, Infectiology Unit, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

  • Faculty of Pharmacy, Microbiology Unit, Bioorganic and Macromolecular Chemistry Laboratory, Free University of Brussels, Brussels, Belgium

  • Department of Gynecology-Obstetrics, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo

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