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Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Received: 19 September 2019     Accepted: 4 November 2019     Published: 26 November 2019
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Abstract

Introduction Marjolin's Ulcer (MU) means all cutaneous malignancies developed on old unsteady scars. The general objective of this study was to report the MU cases in Congo with a literature review. It was a retrospective study conducted at University Teaching Hospital in Brazzaville from January 1998 to December 2017 (a 20-year period). The in-patients for cutaneous cancer histologically confirmed, arose on scarring skin lesions progressive were included. The epidemiological, clinical, histopathological and therapeutical variables were collected. Seven patients were identified. They represented 1.9% of skin cancers. The middle age was 44.4 years. The female predomination was noted with a sex ratio of 2.5. The burn scars was the etiological factor found to all our patients (100%). None of patients had an appropriate care of initial wound. The average time limit of the onset of MU was 34 years. The anatomopathologic examination revealed a squamous cell carcinoma to all our patients (100%). Carcinologic exeresis carried out to one (01) patient (14.28%). The amputation: three (03) patients (42.85%) and the disarticulation: two (02) patients (28.57%). The chemotherapy six (06) patients (85.71%). The decease arose five (05) patients (71.42%) and the entire remission reached to a woman patient (14.28%). This study confirmed the rareness and the severity MU; it also reveals the diagnosis lateness of a great death-rate. The care of quality of burns and chronic injuries, the awareness of patients together with the care givers training could help to improve the prognosis of this affection.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 4, Issue 6)
DOI 10.11648/j.ijcocr.20190406.12
Page(s) 49-53
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Marjolin's Ulcer, Cancer, Scar, Burn

References
[1] Lefebvre P, Rouge D, Chavoin JP, Costagliola M. Dégénérescence de cicatrices, à propos de quatorze observations. Ann Chir Plast Estht 1991; 4: [330], [335].
[2] Sanjay KY, Chandan KJ, Gautam C, Dipendra KS, Abhinav A, Satish K. Marjolin’s Ulcer: Experience from a developping country. Surgery Curr Res 2017; 7: [303].
[3] Copcu E. Marjolin’s ulcer: A preventable complication of burns? Plast Reconstr Surg 2009; 124: [156], [164].
[4] Nthumba PM. Marjolin's ulcers in sub-Saharan Africa. World J Surg. 2010; 34: [2272], [2277].
[5] Da Costa JC. Carcinomatous changes in an area of chronic ulceration, or Marjolin’s ulcer. Ann Surg 1903; 37: [496], [502].
[6] Inglis AM. Squamous cell carcinoma arising in chronic osteomyelitis. Can J Surg 1979; 22: [271], [273].
[7] Oleweiler SD. Marjolin’s ulcer due to venous stasis. Cutis 1995; 56: [168], [170].
[8] Bostwick J, Pendergrast WJ, Vasconez LO. Marjolin's ulcer: an immunologically privileged tumor? Plast Reconstr Surg. 1975; 10: [66], [69]
[9] Hagiwara K, Uezato H, Miyazato H, Nonaka S. Squamous cell carcinoma arising from lupus vulgaris on an old burn scar: diagnosis by polymerase chain reaction. J Dermatol 1996; 23: [883], [889].
[10] Treves N, Pack GT. The development of cancer in burn scars. Analyze and report of 34 cases. Surg Gynec Obstet 1930; 51: [749], [782].
[11] Castillo JL, Goldsmith HS. Burn scar carcinoma. Cancer J Clin. 1968; 18: [140], [142].
[12] Nsondé Malanda J, Lenga-Loumingou I, Gombé Nzi E, Gombé Mbalawa Ch. La Transformation maligne d’une cicatrice de brûlure sur peau noire. Carcinol Prat Afrique 2008; 8: [25], [29]
[13] Kassé AA, Betel E, Deme A, Diop M, Fall MC, Diop PS et al. Les cancers sur cicatrices de brûlures thermiques: A propos de 67 cas. Médecine d'Afrique Noire: 2000, 47: [247], [251].
[14] Dhiab T. Bouzid A. Gamoudi J. Ben Hassouna L. Boulaares F. Khomsi R et al. Carcinomes épidermoïdes sur cicatrices de brûlure: à propos de 68 patients traités à l’Institut Salah Azaïz. Oncologie 2004; 6: [596], [569].
[15] Ouahbi S., Droussi H., Boukind S., Dlimi M., Elatiqi O. K., Elamrani M. D et al. Ulcère De Marjolin: Complication Redoutable des Séquelles de brûlures. Ann Burns Fire Disasters 2013; 16: [199], [205].
[16] Joucdar S, Kismoune M, Boudjemia F., Abchiche M, Fatah S, Zidane D et al. Dégénérescence maligne des séquelles de brûlures: à propos de 35 cas. Ann Medit. Burns Club 1995; 8: [1], [12].
[17] Chlihi A, Bouchta A, Benbrahim A, Bahechar N, Boukind EH. L’ulcère de Marjolin, destinée d’une cicatrice instable. À propos de 54 cas de séquelles de brûlure. Annales de Chirurgie Plastique Esthétique; 2002; 47: [291], [297].
[18] Friedwald WF, Rous P. The initiating and promoting elements in tumor production. J Exp Med 1944; 80: [101].
[19] Mac Kenzie J, Rous P. The experimental disclosure of latent neoplasic changes in tarred skin. J. Exp. Med. 1941; 73: [391].
[20] Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell BW. Marjolin’s Ulcer: Modern Analysis of an Ancient Problem. Plast Reconstr Surg 2009; 123: [184], [192].
[21] Oruc M, Kankaya Y, Sungur N, Ozer K, Isık VM, M. Ulusoy G et al. Clinicopathological evaluation of Marjolin ulcers over two decades. Kaohsiung Journal of Medical Sciences 2017; 33: [327], [333].
[22] Novick M, Guard DA, Hardy SB, Spira M. Burn scar carcinoma: A review and analysis of 46 cases. The Journal of Trauma 1977.17; 10: [809], [817].
[23] Shen R, Zhang J, Zhang F, Du Y, Liang W, Xu L. Clinical characteristics and therapeutic analysis of 51 patients with Marjolin's ulcers. Exp Ther Med 2015; 10: [1364], [1374].
[24] Chalya PL, Mabula JB, Rambau P, Mchembe MD, Kahima KJ, Chandika AB et al. Marjolin’s ulcers at a university teaching hospital in Northwestern Tanzania: A retrospective review of 56 cases. World Journal of Surgical Oncology 2012; 10: [38], [46].
[25] Onah II, Olaitan PB, Ogbonnaya IS, Onuigbo WIB. Marjolin’s ulcer at a Nigerian hospital (1993–2003). J Plast Reconstr Anesthet Surg. 2006; 59: [565], [566].
[26] Bauer T, David T, Rimareix F, Lortat-Jacob A. Marjolin’s ulcer in chronic osteomyelitis: Seven cases and a review of the literature. Rev Chir Orthop Reparatrice Appar Mot 2007; 93: [63], [71]
[27] Al-Zacko SM. Malignancy in chronic burn scar: A 20-year experience in Mosul–Iraq. Burns 2013; 39: [1488], [1491]
[28] Sabin SR, Goldstein G, Rosenthal HG, Haynes KK. Aggressive squamous cell carcinoma originating as a Marjolin’s ulcer. Dematol Surg 2004; 30: [229], [230]
[29] Ozek C, Cankayali R, Bilkay U, Guner U, Gundogan H, Songur E et al. Marjolin’s Ulcers Arising in Burn Scars; Journal of Burn Care & Rehabilitation 2001; 22; 6: [384], [389].
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    Judith Nsondé Malanda, Sophie Bayonne Kombo, Grâce Dulcinée Mabiala Maye, Augustin Bambara Tozoula, Aubièrge Victoire Kimpamboudi Matondo, et al. (2019). Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville. International Journal of Clinical Oncology and Cancer Research, 4(6), 49-53. https://doi.org/10.11648/j.ijcocr.20190406.12

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    ACS Style

    Judith Nsondé Malanda; Sophie Bayonne Kombo; Grâce Dulcinée Mabiala Maye; Augustin Bambara Tozoula; Aubièrge Victoire Kimpamboudi Matondo, et al. Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville. Int. J. Clin. Oncol. Cancer Res. 2019, 4(6), 49-53. doi: 10.11648/j.ijcocr.20190406.12

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    AMA Style

    Judith Nsondé Malanda, Sophie Bayonne Kombo, Grâce Dulcinée Mabiala Maye, Augustin Bambara Tozoula, Aubièrge Victoire Kimpamboudi Matondo, et al. Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville. Int J Clin Oncol Cancer Res. 2019;4(6):49-53. doi: 10.11648/j.ijcocr.20190406.12

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  • @article{10.11648/j.ijcocr.20190406.12,
      author = {Judith Nsondé Malanda and Sophie Bayonne Kombo and Grâce Dulcinée Mabiala Maye and Augustin Bambara Tozoula and Aubièrge Victoire Kimpamboudi Matondo and Eliane Ndounga and Jean Bernard Nkoua Mbon},
      title = {Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {4},
      number = {6},
      pages = {49-53},
      doi = {10.11648/j.ijcocr.20190406.12},
      url = {https://doi.org/10.11648/j.ijcocr.20190406.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20190406.12},
      abstract = {Introduction Marjolin's Ulcer (MU) means all cutaneous malignancies developed on old unsteady scars. The general objective of this study was to report the MU cases in Congo with a literature review. It was a retrospective study conducted at University Teaching Hospital in Brazzaville from January 1998 to December 2017 (a 20-year period). The in-patients for cutaneous cancer histologically confirmed, arose on scarring skin lesions progressive were included. The epidemiological, clinical, histopathological and therapeutical variables were collected. Seven patients were identified. They represented 1.9% of skin cancers. The middle age was 44.4 years. The female predomination was noted with a sex ratio of 2.5. The burn scars was the etiological factor found to all our patients (100%). None of patients had an appropriate care of initial wound. The average time limit of the onset of MU was 34 years. The anatomopathologic examination revealed a squamous cell carcinoma to all our patients (100%). Carcinologic exeresis carried out to one (01) patient (14.28%). The amputation: three (03) patients (42.85%) and the disarticulation: two (02) patients (28.57%). The chemotherapy six (06) patients (85.71%). The decease arose five (05) patients (71.42%) and the entire remission reached to a woman patient (14.28%). This study confirmed the rareness and the severity MU; it also reveals the diagnosis lateness of a great death-rate. The care of quality of burns and chronic injuries, the awareness of patients together with the care givers training could help to improve the prognosis of this affection.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville
    AU  - Judith Nsondé Malanda
    AU  - Sophie Bayonne Kombo
    AU  - Grâce Dulcinée Mabiala Maye
    AU  - Augustin Bambara Tozoula
    AU  - Aubièrge Victoire Kimpamboudi Matondo
    AU  - Eliane Ndounga
    AU  - Jean Bernard Nkoua Mbon
    Y1  - 2019/11/26
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijcocr.20190406.12
    DO  - 10.11648/j.ijcocr.20190406.12
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 49
    EP  - 53
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20190406.12
    AB  - Introduction Marjolin's Ulcer (MU) means all cutaneous malignancies developed on old unsteady scars. The general objective of this study was to report the MU cases in Congo with a literature review. It was a retrospective study conducted at University Teaching Hospital in Brazzaville from January 1998 to December 2017 (a 20-year period). The in-patients for cutaneous cancer histologically confirmed, arose on scarring skin lesions progressive were included. The epidemiological, clinical, histopathological and therapeutical variables were collected. Seven patients were identified. They represented 1.9% of skin cancers. The middle age was 44.4 years. The female predomination was noted with a sex ratio of 2.5. The burn scars was the etiological factor found to all our patients (100%). None of patients had an appropriate care of initial wound. The average time limit of the onset of MU was 34 years. The anatomopathologic examination revealed a squamous cell carcinoma to all our patients (100%). Carcinologic exeresis carried out to one (01) patient (14.28%). The amputation: three (03) patients (42.85%) and the disarticulation: two (02) patients (28.57%). The chemotherapy six (06) patients (85.71%). The decease arose five (05) patients (71.42%) and the entire remission reached to a woman patient (14.28%). This study confirmed the rareness and the severity MU; it also reveals the diagnosis lateness of a great death-rate. The care of quality of burns and chronic injuries, the awareness of patients together with the care givers training could help to improve the prognosis of this affection.
    VL  - 4
    IS  - 6
    ER  - 

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Author Information
  • Oncology Service Teaching Hospital in Brazzaville, Brazzaville, Congo

  • Dermatology Service Talanga? Hospital, Brazzaville, Congo

  • Carcinology Service Teaching Hospital, Ouagadougou, Burkina Faso

  • Surgery Service Makélékélé Hospital, Brazzaville, Congo

  • Oncology Service Teaching Hospital, Brazzaville, Congo

  • Oncology Service Teaching Hospital, Brazzaville, Congo

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