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Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal

Received: 14 November 2022     Accepted: 26 December 2022     Published: 9 January 2023
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Abstract

Concentration of trace nutrients is affected by inflammation; however, there has been limited research on iron and zinc, particularly in children. The objective of the current was to assess associations between inflammation biomarkers and serum ferritin and zinc concentrations., The study used α-1 glycoprotein (AGP) as a second biomarker because C-reactive protein (CRP) detection as a biomarker for inflammation is less sensitive in chronic infections The study utilized cross-sectional data of 1649 preschool Nepalese children from Nepal National Micronutrient Status Survey 2016. A standardized, highly sensitive technique was used to measure CRP and AGP. To obtain associations between CRP and AGP, nutrient concentrations were stratified across classifications of CRP and AGP. Concentrations level greater and smaller than several CRP and AGP cut-off points, namely, 0.5 mg/L, 1.0 mg/L, 3.0 mg/L and 5.0 mg/L (CRP) and 0.5 mg/L, 1.0 mg/L, 1.5 mg/L and 2.0 mg/L (AGP). With CRP biomarker at interval of > 0.5-1 mg/L, the median (25th and 75th percentiles) was 21.6 (11.5, 37.8) mg/L for ferritin; and 83.9 (63.8, 108.8) mg/L for zinc. Corresponding values for ferritin and zinc with AGP biomarker were 22.2 (10.9, 35.9) mg/L and 83.9 (65.6, 106.9) mg/L respectively. CRP concentration at interval of ≥ 5 mg/L was negatively associated with ferritin concentration [adjusted odds ratio (aOR)= 0.44, 95% confidence interval (CI): (0.24, 0.82)]. AGP concentration at interval of ≥ 1.0 mg/L was negatively associated with zinc concentration [aOR: 0.71; 95% CI: (0.50, 1.00)]. High CRP and AGP levels as defined by their low cut-off points (below0.5 mg/L) had no influence on zinc and ferritin concentrations. Using both CRP and AGP as biomarkers for inflammation provides higher precision in the detection of inflammation. This combination of biomarkers is therefore recommended in future research for assessing zinc and iron deficiencies. The negative association of CRP and AGP with serum ferritin and zinc concentrations highlight the need to pay special attention to non-biological factors with elevated levels of the two inflammation biomarkers.

Published in International Journal of Biomedical Science and Engineering (Volume 11, Issue 1)
DOI 10.11648/j.ijbse.20231101.11
Page(s) 1-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

α-1 Acid Glycoprotein, C-reactive Protein, Ferritin, Zinc, Children, Inflammation, Nepal

References
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    Sanjay Rijal, Sher Singh Dahit, Dibya Laxmi Manandhar, Sanjeev Kumar Sahani, Kingsley Agho. (2023). Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal. International Journal of Biomedical Science and Engineering, 11(1), 1-9. https://doi.org/10.11648/j.ijbse.20231101.11

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    Sanjay Rijal; Sher Singh Dahit; Dibya Laxmi Manandhar; Sanjeev Kumar Sahani; Kingsley Agho. Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal. Int. J. Biomed. Sci. Eng. 2023, 11(1), 1-9. doi: 10.11648/j.ijbse.20231101.11

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    AMA Style

    Sanjay Rijal, Sher Singh Dahit, Dibya Laxmi Manandhar, Sanjeev Kumar Sahani, Kingsley Agho. Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal. Int J Biomed Sci Eng. 2023;11(1):1-9. doi: 10.11648/j.ijbse.20231101.11

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  • @article{10.11648/j.ijbse.20231101.11,
      author = {Sanjay Rijal and Sher Singh Dahit and Dibya Laxmi Manandhar and Sanjeev Kumar Sahani and Kingsley Agho},
      title = {Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal},
      journal = {International Journal of Biomedical Science and Engineering},
      volume = {11},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.ijbse.20231101.11},
      url = {https://doi.org/10.11648/j.ijbse.20231101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20231101.11},
      abstract = {Concentration of trace nutrients is affected by inflammation; however, there has been limited research on iron and zinc, particularly in children. The objective of the current was to assess associations between inflammation biomarkers and serum ferritin and zinc concentrations., The study used α-1 glycoprotein (AGP) as a second biomarker because C-reactive protein (CRP) detection as a biomarker for inflammation is less sensitive in chronic infections The study utilized cross-sectional data of 1649 preschool Nepalese children from Nepal National Micronutrient Status Survey 2016. A standardized, highly sensitive technique was used to measure CRP and AGP. To obtain associations between CRP and AGP, nutrient concentrations were stratified across classifications of CRP and AGP. Concentrations level greater and smaller than several CRP and AGP cut-off points, namely, 0.5 mg/L, 1.0 mg/L, 3.0 mg/L and 5.0 mg/L (CRP) and 0.5 mg/L, 1.0 mg/L, 1.5 mg/L and 2.0 mg/L (AGP). With CRP biomarker at interval of > 0.5-1 mg/L, the median (25th and 75th percentiles) was 21.6 (11.5, 37.8) mg/L for ferritin; and 83.9 (63.8, 108.8) mg/L for zinc. Corresponding values for ferritin and zinc with AGP biomarker were 22.2 (10.9, 35.9) mg/L and 83.9 (65.6, 106.9) mg/L respectively. CRP concentration at interval of ≥ 5 mg/L was negatively associated with ferritin concentration [adjusted odds ratio (aOR)= 0.44, 95% confidence interval (CI): (0.24, 0.82)]. AGP concentration at interval of ≥ 1.0 mg/L was negatively associated with zinc concentration [aOR: 0.71; 95% CI: (0.50, 1.00)]. High CRP and AGP levels as defined by their low cut-off points (below0.5 mg/L) had no influence on zinc and ferritin concentrations. Using both CRP and AGP as biomarkers for inflammation provides higher precision in the detection of inflammation. This combination of biomarkers is therefore recommended in future research for assessing zinc and iron deficiencies. The negative association of CRP and AGP with serum ferritin and zinc concentrations highlight the need to pay special attention to non-biological factors with elevated levels of the two inflammation biomarkers.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal
    AU  - Sanjay Rijal
    AU  - Sher Singh Dahit
    AU  - Dibya Laxmi Manandhar
    AU  - Sanjeev Kumar Sahani
    AU  - Kingsley Agho
    Y1  - 2023/01/09
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijbse.20231101.11
    DO  - 10.11648/j.ijbse.20231101.11
    T2  - International Journal of Biomedical Science and Engineering
    JF  - International Journal of Biomedical Science and Engineering
    JO  - International Journal of Biomedical Science and Engineering
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2376-7235
    UR  - https://doi.org/10.11648/j.ijbse.20231101.11
    AB  - Concentration of trace nutrients is affected by inflammation; however, there has been limited research on iron and zinc, particularly in children. The objective of the current was to assess associations between inflammation biomarkers and serum ferritin and zinc concentrations., The study used α-1 glycoprotein (AGP) as a second biomarker because C-reactive protein (CRP) detection as a biomarker for inflammation is less sensitive in chronic infections The study utilized cross-sectional data of 1649 preschool Nepalese children from Nepal National Micronutrient Status Survey 2016. A standardized, highly sensitive technique was used to measure CRP and AGP. To obtain associations between CRP and AGP, nutrient concentrations were stratified across classifications of CRP and AGP. Concentrations level greater and smaller than several CRP and AGP cut-off points, namely, 0.5 mg/L, 1.0 mg/L, 3.0 mg/L and 5.0 mg/L (CRP) and 0.5 mg/L, 1.0 mg/L, 1.5 mg/L and 2.0 mg/L (AGP). With CRP biomarker at interval of > 0.5-1 mg/L, the median (25th and 75th percentiles) was 21.6 (11.5, 37.8) mg/L for ferritin; and 83.9 (63.8, 108.8) mg/L for zinc. Corresponding values for ferritin and zinc with AGP biomarker were 22.2 (10.9, 35.9) mg/L and 83.9 (65.6, 106.9) mg/L respectively. CRP concentration at interval of ≥ 5 mg/L was negatively associated with ferritin concentration [adjusted odds ratio (aOR)= 0.44, 95% confidence interval (CI): (0.24, 0.82)]. AGP concentration at interval of ≥ 1.0 mg/L was negatively associated with zinc concentration [aOR: 0.71; 95% CI: (0.50, 1.00)]. High CRP and AGP levels as defined by their low cut-off points (below0.5 mg/L) had no influence on zinc and ferritin concentrations. Using both CRP and AGP as biomarkers for inflammation provides higher precision in the detection of inflammation. This combination of biomarkers is therefore recommended in future research for assessing zinc and iron deficiencies. The negative association of CRP and AGP with serum ferritin and zinc concentrations highlight the need to pay special attention to non-biological factors with elevated levels of the two inflammation biomarkers.
    VL  - 11
    IS  - 1
    ER  - 

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Author Information
  • Nutrition Section, United Nations Children's Fund (UNICEF), Kathmandu, Nepal

  • Nutrition Section, United Nations Children's Fund (UNICEF), Kathmandu, Nepal

  • Nepali Technical Assistance Groups, Kathmandu, Nepal

  • National Nutrition and Food Security Secretariat, National Planning Commission, Kathmandu, Nepal

  • School of Health Sciences, Western Sydney University, Penrith, New South Wales, Australia

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