Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health

Ayat Fatima; Sayyed Aun Muhammad; Abdul Mateen

doi:doi:10.11648/j.ijast.20250904.12

Communication |

| Peer-Reviewed

Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health

Ayat Fatima^*, Sayyed Aun Muhammad, Abdul Mateen

Published in International Journal of Animal Science and Technology (Volume 9, Issue 4)

Received: 8 September 2025 Accepted: 13 October 2025 Published: 31 October 2025

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The gut microbiome is an extremely complex ecosystem made up of different microorganisms, including viruses, bacteria, fungus, and protozoa. It plays an important role in maintaining host health through protection provided by the immune system against the colonization of the gastrointestinal tract by harmful enteropathogens, ensuring integrity of the epithelial cells, and enhancing absorptive capability of nutrition by enterocytes. The scientific literature of the last years underlined the role of metabolites produced by intestinal microbiota, better known as intestinal metabolome, and how much it can influence the general health of the host. In particular, from literature, it emerged that some metabolites produced by gut microbiota can affect the immune system, metabolism, and gut health. Fecal microbiota transplantation is one method of restoring or augmenting gut microbiota in an individual, especially when one has gastrointestinal problems. While it has also been employed in cases of chronic enteropathies in cats when conventional therapy has failed. Despite the limited application of FMT in cats, there is a requirement for evidence-based guidelines on its implementation in clinical settings to ensure that the intestinal health of felines is at an optimum best after FMT. In this way Veterinarians will have a new way of treating gastrointestinal disorders that are not responding to conventional medications more effectively. Thats why standardized protocols are important to improve the overall health and wellness in the feline patient. The following article highlights the importance and implementation of FMT in feline practice to ensure sound gut health.

Published in	International Journal of Animal Science and Technology (Volume 9, Issue 4)
DOI	10.11648/j.ijast.20250904.12
Page(s)	193-196
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Microbiome, Faecal, Transplant, Feline, Chronic Diarrhea

References

[1]	Paul A, Stayt J. The intestinal microbiome in dogs and cats with diarrhoea as detected by a faecal polymerase chain reaction‐based panel in Perth, Western Australia. Australian Veterinary Journal 2019; 97: 418-21. https://doi.org/10.1111/avj.12867
[2]	Tuniyazi M, Hu X, Fu Y, Zhang N. Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms. Veterinary Sciences 2022; 9: 396. https://doi.org/10.3390/vetsci9080396
[3]	Berlanda M, Innocente G, Simionati B, Di Camillo B, Facchin S, Giron M, et al. Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution. Animals 2021; 11: 1433. https://doi.org/10.3390/ani11051433
[4]	Amorim N, McGovern E, Raposo A, Khatiwada S, Shen S, Koentgen S, et al. Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination. Frontiers in Medicine 2022; 9. https://doi.org/10.3389/fmed.2022.770017
[5]	Rojas CA, Entrolezo Z, Jarett JK, Jospin G, Kingsbury DD, Martin A, et al. Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues. Veterinary Sciences 2023; 10: 561. https://doi.org/10.3390/vetsci10090561
[6]	Sugita K, Shima A, Takahashi K, Ishihara G, Kawano K, Ohmori K. Pilot evaluation of a single oral fecal microbiota transplantation for canine atopic dermatitis. Scientific Reports 2023; 13. https://doi.org/10.1038/s41598-023-35565-y
[7]	Secombe KR, Al-Qadami GH, Subramaniam CB, Bowen JM, Scott J, Van Sebille YZA, et al. Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols. Gut Microbes 2021; 13. https://doi.org/10.1080/19490976.2021.1979878
[8]	Keubler LM, Talbot SR, Bleich A, Boyle EC. Systematic review and meta-analysis of the effect of fecal microbiota transplantation on behavior in animals. Neuroscience & Biobehavioral Reviews 2023; 153: 105316. https://doi.org/10.1016/j.neubiorev.2023.105316
[9]	Fecal transplant for managing GI disorders \| Vet Focus n.d. https://vetfocus.royalcanin.com/en/scientific/fecal-microbiota-transplantation-for-gi-disorders
[10]	Takáčová M, Bomba A, Tóthová C, Micháľová A, Turňa H. Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine? Life 2022; 12: 723. https://doi.org/10.3390/life12050723
[11]	Bokoliya, S. C., Dorsett, Y., Panier, H., & Zhou, Y. (2021b). Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies. Frontiers in Cellular and Infection Microbiology, 11. https://doi.org/10.3389/fcimb.2021.711055
[12]	Ryu, M. O., Lee, S. Y., Kim, S. H., Youn, H. Y., & Seo, K. W. (2024b). Fecal Microbiota Transplantation via Commercial Oral Capsules for Chronic Enteropathies in Dogs and Cats. Journal of Veterinary Clinics, 41(3), 150-156. https://doi.org/10.17555/jvc.2024.41.3.150
[13]	Suchodolski, J. S. (2021b). Analysis of the gut microbiome in dogs and cats. Veterinary Clinical Pathology, 50(S1), 6-17. https://doi.org/10.1111/vcp.13031

Cite This Article

Plain Text BibTeX RIS

APA Style

Fatima, A., Muhammad, S. A., Mateen, A. (2025). Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. International Journal of Animal Science and Technology, 9(4), 193-196. https://doi.org/10.11648/j.ijast.20250904.12

Copy | Download

ACS Style

Fatima, A.; Muhammad, S. A.; Mateen, A. Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. Int. J. Anim. Sci. Technol. 2025, 9(4), 193-196. doi: 10.11648/j.ijast.20250904.12

Copy | Download

AMA Style

Fatima A, Muhammad SA, Mateen A. Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. Int J Anim Sci Technol. 2025;9(4):193-196. doi: 10.11648/j.ijast.20250904.12

Copy | Download

@article{10.11648/j.ijast.20250904.12,
  author = {Ayat Fatima and Sayyed Aun Muhammad and Abdul Mateen},
  title = {Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health
},
  journal = {International Journal of Animal Science and Technology},
  volume = {9},
  number = {4},
  pages = {193-196},
  doi = {10.11648/j.ijast.20250904.12},
  url = {https://doi.org/10.11648/j.ijast.20250904.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20250904.12},
  abstract = {The gut microbiome is an extremely complex ecosystem made up of different microorganisms, including viruses, bacteria, fungus, and protozoa. It plays an important role in maintaining host health through protection provided by the immune system against the colonization of the gastrointestinal tract by harmful enteropathogens, ensuring integrity of the epithelial cells, and enhancing absorptive capability of nutrition by enterocytes. The scientific literature of the last years underlined the role of metabolites produced by intestinal microbiota, better known as intestinal metabolome, and how much it can influence the general health of the host. In particular, from literature, it emerged that some metabolites produced by gut microbiota can affect the immune system, metabolism, and gut health. Fecal microbiota transplantation is one method of restoring or augmenting gut microbiota in an individual, especially when one has gastrointestinal problems. While it has also been employed in cases of chronic enteropathies in cats when conventional therapy has failed. Despite the limited application of FMT in cats, there is a requirement for evidence-based guidelines on its implementation in clinical settings to ensure that the intestinal health of felines is at an optimum best after FMT. In this way Veterinarians will have a new way of treating gastrointestinal disorders that are not responding to conventional medications more effectively. Thats why standardized protocols are important to improve the overall health and wellness in the feline patient. The following article highlights the importance and implementation of FMT in feline practice to ensure sound gut health.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health

AU  - Ayat Fatima
AU  - Sayyed Aun Muhammad
AU  - Abdul Mateen
Y1  - 2025/10/31
PY  - 2025
N1  - https://doi.org/10.11648/j.ijast.20250904.12
DO  - 10.11648/j.ijast.20250904.12
T2  - International Journal of Animal Science and Technology
JF  - International Journal of Animal Science and Technology
JO  - International Journal of Animal Science and Technology
SP  - 193
EP  - 196
PB  - Science Publishing Group
SN  - 2640-1312
UR  - https://doi.org/10.11648/j.ijast.20250904.12
AB  - The gut microbiome is an extremely complex ecosystem made up of different microorganisms, including viruses, bacteria, fungus, and protozoa. It plays an important role in maintaining host health through protection provided by the immune system against the colonization of the gastrointestinal tract by harmful enteropathogens, ensuring integrity of the epithelial cells, and enhancing absorptive capability of nutrition by enterocytes. The scientific literature of the last years underlined the role of metabolites produced by intestinal microbiota, better known as intestinal metabolome, and how much it can influence the general health of the host. In particular, from literature, it emerged that some metabolites produced by gut microbiota can affect the immune system, metabolism, and gut health. Fecal microbiota transplantation is one method of restoring or augmenting gut microbiota in an individual, especially when one has gastrointestinal problems. While it has also been employed in cases of chronic enteropathies in cats when conventional therapy has failed. Despite the limited application of FMT in cats, there is a requirement for evidence-based guidelines on its implementation in clinical settings to ensure that the intestinal health of felines is at an optimum best after FMT. In this way Veterinarians will have a new way of treating gastrointestinal disorders that are not responding to conventional medications more effectively. Thats why standardized protocols are important to improve the overall health and wellness in the feline patient. The following article highlights the importance and implementation of FMT in feline practice to ensure sound gut health.

VL  - 9
IS  - 4
ER  -

Copy | Download

Author Information

Ayat Fatima

Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang, Pakistan

Contact Email
Sayyed Aun Muhammad

Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang, Pakistan
Abdul Mateen

Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang, Pakistan

Download PDF

Submit an Article

Sections

Plain Text BibTeX RIS

APA Style

Fatima, A., Muhammad, S. A., Mateen, A. (2025). Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. International Journal of Animal Science and Technology, 9(4), 193-196. https://doi.org/10.11648/j.ijast.20250904.12

Copy | Download

ACS Style

Fatima, A.; Muhammad, S. A.; Mateen, A. Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. Int. J. Anim. Sci. Technol. 2025, 9(4), 193-196. doi: 10.11648/j.ijast.20250904.12

Copy | Download

AMA Style

Fatima A, Muhammad SA, Mateen A. Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health. Int J Anim Sci Technol. 2025;9(4):193-196. doi: 10.11648/j.ijast.20250904.12

Copy | Download

@article{10.11648/j.ijast.20250904.12,
  author = {Ayat Fatima and Sayyed Aun Muhammad and Abdul Mateen},
  title = {Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health
},
  journal = {International Journal of Animal Science and Technology},
  volume = {9},
  number = {4},
  pages = {193-196},
  doi = {10.11648/j.ijast.20250904.12},
  url = {https://doi.org/10.11648/j.ijast.20250904.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20250904.12},
  abstract = {The gut microbiome is an extremely complex ecosystem made up of different microorganisms, including viruses, bacteria, fungus, and protozoa. It plays an important role in maintaining host health through protection provided by the immune system against the colonization of the gastrointestinal tract by harmful enteropathogens, ensuring integrity of the epithelial cells, and enhancing absorptive capability of nutrition by enterocytes. The scientific literature of the last years underlined the role of metabolites produced by intestinal microbiota, better known as intestinal metabolome, and how much it can influence the general health of the host. In particular, from literature, it emerged that some metabolites produced by gut microbiota can affect the immune system, metabolism, and gut health. Fecal microbiota transplantation is one method of restoring or augmenting gut microbiota in an individual, especially when one has gastrointestinal problems. While it has also been employed in cases of chronic enteropathies in cats when conventional therapy has failed. Despite the limited application of FMT in cats, there is a requirement for evidence-based guidelines on its implementation in clinical settings to ensure that the intestinal health of felines is at an optimum best after FMT. In this way Veterinarians will have a new way of treating gastrointestinal disorders that are not responding to conventional medications more effectively. Thats why standardized protocols are important to improve the overall health and wellness in the feline patient. The following article highlights the importance and implementation of FMT in feline practice to ensure sound gut health.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Microbiome Restoration via Fecal Transplant: A Novel Approach to Feline Gut Health

AU  - Ayat Fatima
AU  - Sayyed Aun Muhammad
AU  - Abdul Mateen
Y1  - 2025/10/31
PY  - 2025
N1  - https://doi.org/10.11648/j.ijast.20250904.12
DO  - 10.11648/j.ijast.20250904.12
T2  - International Journal of Animal Science and Technology
JF  - International Journal of Animal Science and Technology
JO  - International Journal of Animal Science and Technology
SP  - 193
EP  - 196
PB  - Science Publishing Group
SN  - 2640-1312
UR  - https://doi.org/10.11648/j.ijast.20250904.12
AB  - The gut microbiome is an extremely complex ecosystem made up of different microorganisms, including viruses, bacteria, fungus, and protozoa. It plays an important role in maintaining host health through protection provided by the immune system against the colonization of the gastrointestinal tract by harmful enteropathogens, ensuring integrity of the epithelial cells, and enhancing absorptive capability of nutrition by enterocytes. The scientific literature of the last years underlined the role of metabolites produced by intestinal microbiota, better known as intestinal metabolome, and how much it can influence the general health of the host. In particular, from literature, it emerged that some metabolites produced by gut microbiota can affect the immune system, metabolism, and gut health. Fecal microbiota transplantation is one method of restoring or augmenting gut microbiota in an individual, especially when one has gastrointestinal problems. While it has also been employed in cases of chronic enteropathies in cats when conventional therapy has failed. Despite the limited application of FMT in cats, there is a requirement for evidence-based guidelines on its implementation in clinical settings to ensure that the intestinal health of felines is at an optimum best after FMT. In this way Veterinarians will have a new way of treating gastrointestinal disorders that are not responding to conventional medications more effectively. Thats why standardized protocols are important to improve the overall health and wellness in the feline patient. The following article highlights the importance and implementation of FMT in feline practice to ensure sound gut health.

VL  - 9
IS  - 4
ER  -

Copy | Download