| Peer-Reviewed

The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers

Received: 30 October 2017     Accepted: 16 November 2017     Published: 3 January 2018
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Abstract

miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal and urogenital cancers. The cytosine-phosphoguanine (CpG)-island methylation was one of the most significant factors which controlled the expression of miR-203. Furthermore, miR-203 participated in these cancers via targeting its downstream genes. However, the precise regulatory mechanisms underlying miR-203 association with these cancers are still not fully understood. The aim of this review is to sum up the collective knowledge of miR-203 in gastrointestinal and urogenital cancers.

Published in International Journal of Animal Science and Technology (Volume 1, Issue 1)
DOI 10.11648/j.ijast.20170101.12
Page(s) 5-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

miR-203, Gastrointestinal Cancers, Urogenital Cancers, Methylation, Targeting

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  • APA Style

    Lei Zhan, Bing Wei. (2018). The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers. International Journal of Animal Science and Technology, 1(1), 5-14. https://doi.org/10.11648/j.ijast.20170101.12

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    ACS Style

    Lei Zhan; Bing Wei. The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers. Int. J. Anim. Sci. Technol. 2018, 1(1), 5-14. doi: 10.11648/j.ijast.20170101.12

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    AMA Style

    Lei Zhan, Bing Wei. The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers. Int J Anim Sci Technol. 2018;1(1):5-14. doi: 10.11648/j.ijast.20170101.12

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  • @article{10.11648/j.ijast.20170101.12,
      author = {Lei Zhan and Bing Wei},
      title = {The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers},
      journal = {International Journal of Animal Science and Technology},
      volume = {1},
      number = {1},
      pages = {5-14},
      doi = {10.11648/j.ijast.20170101.12},
      url = {https://doi.org/10.11648/j.ijast.20170101.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20170101.12},
      abstract = {miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal and urogenital cancers. The cytosine-phosphoguanine (CpG)-island methylation was one of the most significant factors which controlled the expression of miR-203. Furthermore, miR-203 participated in these cancers via targeting its downstream genes. However, the precise regulatory mechanisms underlying miR-203 association with these cancers are still not fully understood. The aim of this review is to sum up the collective knowledge of miR-203 in gastrointestinal and urogenital cancers.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers
    AU  - Lei Zhan
    AU  - Bing Wei
    Y1  - 2018/01/03
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijast.20170101.12
    DO  - 10.11648/j.ijast.20170101.12
    T2  - International Journal of Animal Science and Technology
    JF  - International Journal of Animal Science and Technology
    JO  - International Journal of Animal Science and Technology
    SP  - 5
    EP  - 14
    PB  - Science Publishing Group
    SN  - 2640-1312
    UR  - https://doi.org/10.11648/j.ijast.20170101.12
    AB  - miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal and urogenital cancers. The cytosine-phosphoguanine (CpG)-island methylation was one of the most significant factors which controlled the expression of miR-203. Furthermore, miR-203 participated in these cancers via targeting its downstream genes. However, the precise regulatory mechanisms underlying miR-203 association with these cancers are still not fully understood. The aim of this review is to sum up the collective knowledge of miR-203 in gastrointestinal and urogenital cancers.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China

  • Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China

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