| Peer-Reviewed

A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery

Received: 28 February 2023     Accepted: 28 March 2023     Published: 11 April 2023
Views:       Downloads:
Abstract

Kounis syndrome is a hypersensitivity coronary disorder associated with several triggers, such as drugs, foods, environmental, coronary stents and other factors. It was originally proposed by the Greek cardiologist Nicholas Kounis in 1991. Kounis syndrome is a life-threatening and challenging emergency disease, which is constantly being recognized and studied. It is a disease that is constantly being recognized and Kounis syndrome can be classified into three types, involving coronary artery spasm, plaque rupture or stent thrombosis respectively. Most patients with coronary artery spasm caused by allergies can recover completely after active treatment, and the prognosis is good. If not, it may cause severe myocardial damage and even myocardial infarction, which threatens the patient's life. In our case, a 56-year-old female patient was scheduled to undergo right pelvic resection. A few minutes after the start of intravenous succinylated gelatin infusion, she was experienced a decrease in heart rate, blood pressure, oxygen saturation and ST elevation on 2-lead. An anaphylactic reaction was suspected after rapid differential diagnosis and gradually recovered with treatment. In this context, a rapid differential diagnosis and a highly suspicious become essential, because the management of Kounis syndrome is different from the traditional acute coronary syndrome. Kounis syndrome requires simultaneous diagnosis and treatment of both allergic reaction and acute coronary syndrome based on their manifestations and risk factors. This case describes the onset, development, and recovery of Kounis syndrome in this patient in detail, and illustrates the classification, pathophysiology, and treatment of Kounis syndrome. It is hoped that through the management of this case, the occurrence of Kounis syndrome can be rapidly identified and treated accordingly so that avoiding disaster for patients.

Published in International Journal of Anesthesia and Clinical Medicine (Volume 11, Issue 1)
DOI 10.11648/j.ijacm.20231101.15
Page(s) 23-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Kounis Syndrome, Anaphylaxis, Gelofusine

References
[1] R. Desai, T. Parekh, U. Patel, H. K. Fong, and R. Sachdeva, “Epidemiology of acute coronary syndrome co-existent with allergic/hypersensitivity/anaphylactic reactions (Kounis syndrome) in the United States: A nationwide inpatient analysis,” International Journal of Cardiology, vol. 292, pp. 35–38, 2019.
[2] M. Abdelghany, R. Subedi, S. Shah, and H. Kozman, “Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome.” International Journal of Cardiology, vol. 232, pp. 1–4, 2017.
[3] M. Giovannini et al., “Kounis syndrome: a clinical entity penetrating from pediatrics to geriatrics,” J Geriatr Cardiol, vol. 17, no. 5, pp. 294–299, May 2020.
[4] B. Dai, J. Cavaye, M. Judd, J. Beuth, H. Iswariah, and U. Gurunathan, “Perioperative Presentations of Kounis Syndrome: A Systematic Literature Review,” J Cardiothorac Vasc Anesth, vol. 36, no. 7, pp. 2070–2076, Jul. 2022.
[5] S. Miura, T. Yamashita, M. Murata, and N. G. Kounis, “Uncommon but imperative cause of repeated acute stent thrombosis: Kounis syndrome type III,” BMJ Case Rep, vol. 14, no. 3, p. e240704, Mar. 2021.
[6] P. Lieberman et al., “The diagnosis and management of anaphylaxis: An updated practice parameter,” Journal of Allergy and Clinical Immunology, vol. 115, no. 3, pp. S483–S523, Mar. 2005.
[7] Pascale Dewachter, “Anaphylaxis and Anesthesia: Controversies and New Insights,” Survey of Anesthesiology, vol. 54, no. 4, pp. 186–187, Aug. 2010.
[8] S. Vaina et al., “Anaphylactic cardiovascular collapse manifesting as myocardial infarction following salad consumption. A case of Kounis variant type I syndrome,” Acta Biomed, vol. 91, no. 1, pp. 134–138, 2020.
[9] N. G. Kounis, “Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management,” Clin Chem Lab Med, vol. 54, no. 10, pp. 1545–1559, Oct. 2016.
[10] N. G. Kounis, I. Koniari, D. Velissaris, G. Tzanis, and G. Hahalis, “Kounis Syndrome—not a Single-organ Arterial Disorder but a Multisystem and Multidisciplinary Disease,” Balkan Med J, vol. 36, no. 4, pp. 212–221, Jul. 2019.
[11] A. Navarro-Navajas, I. Casallas, D. Isaza, P. Ortiz, D. Baracaldo-Santamaría, and C.-A. Calderon-Ospina, “Type III Kounis Syndrome Secondary to Ciprofloxacin-Induced Hypersensitivity,” Medicina (Kaunas), vol. 58, no. 7, p. 855, Jun. 2022.
[12] E. Sciatti et al., “Kounis syndrome, a disease to know: Case report and review of the literature,” Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo, vol. 88, no. 1, 2018.
[13] M. Omri, H. Kraiem, O. Mejri, M. Naija, and N. Chebili, “Management of Kounis syndrome: two case reports,” J Med Case Rep, vol. 11, no. 1, p. 145, May 2017.
[14] F.-J. Neumann et al., “2018 ESC/EACTS Guidelines on myocardial revascularization,” European Heart Journal, vol. 40, no. 2, pp. 87–165, Jan. 2019.
[15] E. Poggiali et al., “Kounis syndrome: from an unexpected case in the Emergency Room to a review of the literature.” Acta Biomed, vol. 93, no. 1, p. e2022002, 2022.
Cite This Article
  • APA Style

    Peipei Sun, Tao Zhu. (2023). A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery. International Journal of Anesthesia and Clinical Medicine, 11(1), 23-27. https://doi.org/10.11648/j.ijacm.20231101.15

    Copy | Download

    ACS Style

    Peipei Sun; Tao Zhu. A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery. Int. J. Anesth. Clin. Med. 2023, 11(1), 23-27. doi: 10.11648/j.ijacm.20231101.15

    Copy | Download

    AMA Style

    Peipei Sun, Tao Zhu. A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery. Int J Anesth Clin Med. 2023;11(1):23-27. doi: 10.11648/j.ijacm.20231101.15

    Copy | Download

  • @article{10.11648/j.ijacm.20231101.15,
      author = {Peipei Sun and Tao Zhu},
      title = {A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery},
      journal = {International Journal of Anesthesia and Clinical Medicine},
      volume = {11},
      number = {1},
      pages = {23-27},
      doi = {10.11648/j.ijacm.20231101.15},
      url = {https://doi.org/10.11648/j.ijacm.20231101.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20231101.15},
      abstract = {Kounis syndrome is a hypersensitivity coronary disorder associated with several triggers, such as drugs, foods, environmental, coronary stents and other factors. It was originally proposed by the Greek cardiologist Nicholas Kounis in 1991. Kounis syndrome is a life-threatening and challenging emergency disease, which is constantly being recognized and studied. It is a disease that is constantly being recognized and Kounis syndrome can be classified into three types, involving coronary artery spasm, plaque rupture or stent thrombosis respectively. Most patients with coronary artery spasm caused by allergies can recover completely after active treatment, and the prognosis is good. If not, it may cause severe myocardial damage and even myocardial infarction, which threatens the patient's life. In our case, a 56-year-old female patient was scheduled to undergo right pelvic resection. A few minutes after the start of intravenous succinylated gelatin infusion, she was experienced a decrease in heart rate, blood pressure, oxygen saturation and ST elevation on 2-lead. An anaphylactic reaction was suspected after rapid differential diagnosis and gradually recovered with treatment. In this context, a rapid differential diagnosis and a highly suspicious become essential, because the management of Kounis syndrome is different from the traditional acute coronary syndrome. Kounis syndrome requires simultaneous diagnosis and treatment of both allergic reaction and acute coronary syndrome based on their manifestations and risk factors. This case describes the onset, development, and recovery of Kounis syndrome in this patient in detail, and illustrates the classification, pathophysiology, and treatment of Kounis syndrome. It is hoped that through the management of this case, the occurrence of Kounis syndrome can be rapidly identified and treated accordingly so that avoiding disaster for patients.},
     year = {2023}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - A Case of Kounis Syndrome Caused by Anaphylaxis During Surgery
    AU  - Peipei Sun
    AU  - Tao Zhu
    Y1  - 2023/04/11
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijacm.20231101.15
    DO  - 10.11648/j.ijacm.20231101.15
    T2  - International Journal of Anesthesia and Clinical Medicine
    JF  - International Journal of Anesthesia and Clinical Medicine
    JO  - International Journal of Anesthesia and Clinical Medicine
    SP  - 23
    EP  - 27
    PB  - Science Publishing Group
    SN  - 2997-2698
    UR  - https://doi.org/10.11648/j.ijacm.20231101.15
    AB  - Kounis syndrome is a hypersensitivity coronary disorder associated with several triggers, such as drugs, foods, environmental, coronary stents and other factors. It was originally proposed by the Greek cardiologist Nicholas Kounis in 1991. Kounis syndrome is a life-threatening and challenging emergency disease, which is constantly being recognized and studied. It is a disease that is constantly being recognized and Kounis syndrome can be classified into three types, involving coronary artery spasm, plaque rupture or stent thrombosis respectively. Most patients with coronary artery spasm caused by allergies can recover completely after active treatment, and the prognosis is good. If not, it may cause severe myocardial damage and even myocardial infarction, which threatens the patient's life. In our case, a 56-year-old female patient was scheduled to undergo right pelvic resection. A few minutes after the start of intravenous succinylated gelatin infusion, she was experienced a decrease in heart rate, blood pressure, oxygen saturation and ST elevation on 2-lead. An anaphylactic reaction was suspected after rapid differential diagnosis and gradually recovered with treatment. In this context, a rapid differential diagnosis and a highly suspicious become essential, because the management of Kounis syndrome is different from the traditional acute coronary syndrome. Kounis syndrome requires simultaneous diagnosis and treatment of both allergic reaction and acute coronary syndrome based on their manifestations and risk factors. This case describes the onset, development, and recovery of Kounis syndrome in this patient in detail, and illustrates the classification, pathophysiology, and treatment of Kounis syndrome. It is hoped that through the management of this case, the occurrence of Kounis syndrome can be rapidly identified and treated accordingly so that avoiding disaster for patients.
    VL  - 11
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China

  • Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China

  • Sections