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Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients

Received: 4 August 2015     Accepted: 27 August 2015     Published: 3 November 2015
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Abstract

Background: The metabolic syndrome is a clustering of metabolic abnormalities and cardiovascular risk factors. It is vital to start the lifestyle interventions and treatment early in patients with metabolic syndrome to prevent the twin global epidemics of type 2diabetes and CVD. Objective: to investigate the overall effects of omega-3 fatty acids supplementation In addition to Dietary Approaches to Stop Hypertension (DASH) nutritional intervention on the lipid profile in patients with metabolic syndrome and to study if the addition of DASH diet will alleviate the rise in LDL- C that occurs with ω-3 fatty acid supplementation. Research design and methods: This was a prospective interventional outpatient trial conducted on 42 patients with the metabolic syndrome. They received ω-3 fatty acid supplementation 1 g/d in addition to DASH nutritional education for 12 weeks: the DASH diet with increased consumption of fruit, vegetables, low-fat dairy and whole grains and lower in saturated fat, total fat, and cholesterol. The main outcome measures were the lipid profile of the patients with metabolic syndrome. Results: ω-3 fatty acid together with The DASH diet significantly changed the mean of all parameters of lipid profile in metabolic syndrome patients. After 12 weeks, there was a significant increase in HDL-C (14%), significant reductions in TG (37.7%), LDL (29.4%) and a significant reduction in Non HDL-C (24.7%). Conclusion: this study demonstrated that the DASH diet optimizes and complements the effect of ω-3 fatty acid on the lipid profile of patients with metabolic syndrome by alleviating the rise in LDL- C that occurs with omega supplementation.

Published in European Journal of Preventive Medicine (Volume 3, Issue 6)
DOI 10.11648/j.ejpm.20150306.13
Page(s) 180-183
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hypertriglyceridemia, Omega-3 Fatty Acids, LDL, Metabolic Syndrome, DASH, LDL

References
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[2] Sattar N, Gaw A, Scherbakova O. Metabolic syndrome with and without Creactive protein as a predictor of coronary. Circulation; 108:414-9, 2003.
[3] Praveen S and Mishra S, Early identification prevents type ii diabetes and cardiovascular disease Indian Journal of Clinical Biochemistry; 22 (1): 1-3, 2007.
[4] Young-Hyman D, Schlundt DG, Herman L, De Luca F, Counts D: Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children. Diabetes Care; 24: 1359 –1364, 2001.
[5] International Diabetes Federation (IDF) Consensus Worldwide Definition of the Metabolic Syndrome, 2009, available at http://www.idf.org/metabolic-syndrome, last accessed in June 2015.
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[16] Yacowitz H, Fleischman AI, Amsden RT. Effects of dietary calcium upon lipid metabolism in rats fed saturated or unsaturated fat. J. Nutr. 92 (3): 389-392, 1967.
[17] Lopes HF, Martin KL, Nashar K, Morrow JD, Goodfriend TL, Egan BM.: DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity.Hypertension 41: 422 –430, 2003.
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Cite This Article
  • APA Style

    Ghada Mahmoud Khafagy, Mayssa Ebrahim Ali. (2015). Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients. European Journal of Preventive Medicine, 3(6), 180-183. https://doi.org/10.11648/j.ejpm.20150306.13

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    ACS Style

    Ghada Mahmoud Khafagy; Mayssa Ebrahim Ali. Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients. Eur. J. Prev. Med. 2015, 3(6), 180-183. doi: 10.11648/j.ejpm.20150306.13

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    AMA Style

    Ghada Mahmoud Khafagy, Mayssa Ebrahim Ali. Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients. Eur J Prev Med. 2015;3(6):180-183. doi: 10.11648/j.ejpm.20150306.13

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  • @article{10.11648/j.ejpm.20150306.13,
      author = {Ghada Mahmoud Khafagy and Mayssa Ebrahim Ali},
      title = {Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients},
      journal = {European Journal of Preventive Medicine},
      volume = {3},
      number = {6},
      pages = {180-183},
      doi = {10.11648/j.ejpm.20150306.13},
      url = {https://doi.org/10.11648/j.ejpm.20150306.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20150306.13},
      abstract = {Background: The metabolic syndrome is a clustering of metabolic abnormalities and cardiovascular risk factors. It is vital to start the lifestyle interventions and treatment early in patients with metabolic syndrome to prevent the twin global epidemics of type 2diabetes and CVD. Objective: to investigate the overall effects of omega-3 fatty acids supplementation In addition to Dietary Approaches to Stop Hypertension (DASH) nutritional intervention on the lipid profile in patients with metabolic syndrome and to study if the addition of DASH diet will alleviate the rise in LDL- C that occurs with ω-3 fatty acid supplementation. Research design and methods: This was a prospective interventional outpatient trial conducted on 42 patients with the metabolic syndrome. They received ω-3 fatty acid supplementation 1 g/d in addition to DASH nutritional education for 12 weeks: the DASH diet with increased consumption of fruit, vegetables, low-fat dairy and whole grains and lower in saturated fat, total fat, and cholesterol. The main outcome measures were the lipid profile of the patients with metabolic syndrome. Results: ω-3 fatty acid together with The DASH diet significantly changed the mean of all parameters of lipid profile in metabolic syndrome patients. After 12 weeks, there was a significant increase in HDL-C (14%), significant reductions in TG (37.7%), LDL (29.4%) and a significant reduction in Non HDL-C (24.7%). Conclusion: this study demonstrated that the DASH diet optimizes and complements the effect of ω-3 fatty acid on the lipid profile of patients with metabolic syndrome by alleviating the rise in LDL- C that occurs with omega supplementation.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Optimizing the Effect of ω-3 Fatty Acids on the Lipid Profile in Metabolic Syndrome Patients
    AU  - Ghada Mahmoud Khafagy
    AU  - Mayssa Ebrahim Ali
    Y1  - 2015/11/03
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ejpm.20150306.13
    DO  - 10.11648/j.ejpm.20150306.13
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 180
    EP  - 183
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20150306.13
    AB  - Background: The metabolic syndrome is a clustering of metabolic abnormalities and cardiovascular risk factors. It is vital to start the lifestyle interventions and treatment early in patients with metabolic syndrome to prevent the twin global epidemics of type 2diabetes and CVD. Objective: to investigate the overall effects of omega-3 fatty acids supplementation In addition to Dietary Approaches to Stop Hypertension (DASH) nutritional intervention on the lipid profile in patients with metabolic syndrome and to study if the addition of DASH diet will alleviate the rise in LDL- C that occurs with ω-3 fatty acid supplementation. Research design and methods: This was a prospective interventional outpatient trial conducted on 42 patients with the metabolic syndrome. They received ω-3 fatty acid supplementation 1 g/d in addition to DASH nutritional education for 12 weeks: the DASH diet with increased consumption of fruit, vegetables, low-fat dairy and whole grains and lower in saturated fat, total fat, and cholesterol. The main outcome measures were the lipid profile of the patients with metabolic syndrome. Results: ω-3 fatty acid together with The DASH diet significantly changed the mean of all parameters of lipid profile in metabolic syndrome patients. After 12 weeks, there was a significant increase in HDL-C (14%), significant reductions in TG (37.7%), LDL (29.4%) and a significant reduction in Non HDL-C (24.7%). Conclusion: this study demonstrated that the DASH diet optimizes and complements the effect of ω-3 fatty acid on the lipid profile of patients with metabolic syndrome by alleviating the rise in LDL- C that occurs with omega supplementation.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • Department of Family Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

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