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Nutritional Genomics in Primary Open-Angle Glaucoma

Received: 20 May 2015     Accepted: 27 May 2015     Published: 28 May 2015
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Abstract

Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by a high intraocular pressure (IOP), an alteration of the optic nerve head and a loss of visual field. POAG is one of the main causes of blindness worldwide, currently with no cure. POAG is a multifactorial disease that involves both genetic and environmental factors, so that the development of the glaucomatous disease is determined not only by the individual effect of each of these factors, but also by the joint effect of the interaction between all of them. To study the interactions between these factors and their association with POAG is a very hard task, but we can approach this issue investigating_the genetics-nutrition relationship and the effect of this binomial on the glaucomatous pathogenesis by means of the Nutritional Genomics. The influence of nutrition on glaucomatous pathogenesis has been studied since long time ago. For example, it is well known the role of vitamins in eye health. However, the interaction of genetic and nutritional factors and their effect on glaucomatous optic neuropathy are investigated recently. In this article we review the genetics of primary open-angle glaucoma, as well as various risk factors for this disease, including nutritional factors. Also, we review the articles studying the interaction of all these factors (genetics and nutritionals) in relation to this optic neuropathy.

Published in European Journal of Clinical and Biomedical Sciences (Volume 1, Issue 1)
DOI 10.11648/j.ejcbs.20150101.11
Page(s) 1-9
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

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Keywords

Primary Open-Angle Glaucoma, Genetics, Nutrigenetics, Nutrigenomics, Nutrition, Diet

References
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    Asensio-Marquez E. M., Ortega-Azorin C., Zanon-Moreno V. (2015). Nutritional Genomics in Primary Open-Angle Glaucoma. European Journal of Clinical and Biomedical Sciences, 1(1), 1-9. https://doi.org/10.11648/j.ejcbs.20150101.11

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    Asensio-Marquez E. M.; Ortega-Azorin C.; Zanon-Moreno V. Nutritional Genomics in Primary Open-Angle Glaucoma. Eur. J. Clin. Biomed. Sci. 2015, 1(1), 1-9. doi: 10.11648/j.ejcbs.20150101.11

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    AMA Style

    Asensio-Marquez E. M., Ortega-Azorin C., Zanon-Moreno V. Nutritional Genomics in Primary Open-Angle Glaucoma. Eur J Clin Biomed Sci. 2015;1(1):1-9. doi: 10.11648/j.ejcbs.20150101.11

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  • @article{10.11648/j.ejcbs.20150101.11,
      author = {Asensio-Marquez E. M. and Ortega-Azorin C. and Zanon-Moreno V.},
      title = {Nutritional Genomics in Primary Open-Angle Glaucoma},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {1},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.ejcbs.20150101.11},
      url = {https://doi.org/10.11648/j.ejcbs.20150101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20150101.11},
      abstract = {Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by a high intraocular pressure (IOP), an alteration of the optic nerve head and a loss of visual field. POAG is one of the main causes of blindness worldwide, currently with no cure. POAG is a multifactorial disease that involves both genetic and environmental factors, so that the development of the glaucomatous disease is determined not only by the individual effect of each of these factors, but also by the joint effect of the interaction between all of them. To study the interactions between these factors and their association with POAG is a very hard task, but we can approach this issue investigating_the genetics-nutrition relationship and the effect of this binomial on the glaucomatous pathogenesis by means of the Nutritional Genomics. The influence of nutrition on glaucomatous pathogenesis has been studied since long time ago. For example, it is well known the role of vitamins in eye health. However, the interaction of genetic and nutritional factors and their effect on glaucomatous optic neuropathy are investigated recently. In this article we review the genetics of primary open-angle glaucoma, as well as various risk factors for this disease, including nutritional factors. Also, we review the articles studying the interaction of all these factors (genetics and nutritionals) in relation to this optic neuropathy.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Nutritional Genomics in Primary Open-Angle Glaucoma
    AU  - Asensio-Marquez E. M.
    AU  - Ortega-Azorin C.
    AU  - Zanon-Moreno V.
    Y1  - 2015/05/28
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ejcbs.20150101.11
    DO  - 10.11648/j.ejcbs.20150101.11
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20150101.11
    AB  - Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by a high intraocular pressure (IOP), an alteration of the optic nerve head and a loss of visual field. POAG is one of the main causes of blindness worldwide, currently with no cure. POAG is a multifactorial disease that involves both genetic and environmental factors, so that the development of the glaucomatous disease is determined not only by the individual effect of each of these factors, but also by the joint effect of the interaction between all of them. To study the interactions between these factors and their association with POAG is a very hard task, but we can approach this issue investigating_the genetics-nutrition relationship and the effect of this binomial on the glaucomatous pathogenesis by means of the Nutritional Genomics. The influence of nutrition on glaucomatous pathogenesis has been studied since long time ago. For example, it is well known the role of vitamins in eye health. However, the interaction of genetic and nutritional factors and their effect on glaucomatous optic neuropathy are investigated recently. In this article we review the genetics of primary open-angle glaucoma, as well as various risk factors for this disease, including nutritional factors. Also, we review the articles studying the interaction of all these factors (genetics and nutritionals) in relation to this optic neuropathy.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Department of Preventive Medicine and Public Health and CIBER Physiopathology of Obesity and Nutrition, School of Medicine, University of Valencia, Valencia, Spain

  • Ophthalmic Research Unit “Santiago Grisolia”, Dr. Peset University Hospital, Valencia, Spain

  • Department of Preventive Medicine and Public Health and CIBER Physiopathology of Obesity and Nutrition, School of Medicine, University of Valencia, Valencia, Spain

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