Cerebral venous sinus thrombosis (CVST) is responsible for about 0.5% to 3% of all strokes, with a markedly higher frequency noted in young women. This condition is determined by several factors; in addition to established risk factors, new contributors that have become better recognized but less well-documented in the tropics include obesity, polycystic ovary syndrome (PCOS), COVID-19 infection, and vaccine-associated thrombocytopenia and thrombosis. We describe the third known case, and the first described in Africa, of CVST in a woman with PCOS and no recognizable pro-thrombotic disorder. A 42-year-old female patient, right-handed, nulligest, and obese presented with a history of infertility and menstrual cycle disorders. She was admitted to our department due to the onset of atypical headaches that progressed subacutely and were associated to generalized tonic-clonic seizures. Neurological assessment upon admission revealed intracranial hypertension syndrome. Brain MRI showed extensive CVST on the left side, involving the lateral sinus and the internal jugular vein. The diagnosis of PCOS was made according to the Rotterdam criteria. A multidisciplinary management strategy was implemented. Comprehensive studies are essential to elucidate the factors associated with CVST in women diagnosed with PCOS, which will facilitate risk assessment and the formulation of preventive measures.
Published in | Clinical Neurology and Neuroscience (Volume 8, Issue 4) |
DOI | 10.11648/j.cnn.20240804.12 |
Page(s) | 54-60 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Polycystic Ovary Syndrome (PCOS), Cerebral Venous Sinus Thrombosis (CVST), Risk Factor, Case Report, Abidjan
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APA Style
Magala, G. C., Aka, A. D., Offoumou, F. D., Amon-Tanoh, M., Kadjo, C. V., et al. (2024). Polycystic Ovary Syndrome (PCOS) an Emerging Risk Factor of Cerebral Venous Sinus Thrombosis (CVST): A Case Report and Literature Review. Clinical Neurology and Neuroscience, 8(4), 54-60. https://doi.org/10.11648/j.cnn.20240804.12
ACS Style
Magala, G. C.; Aka, A. D.; Offoumou, F. D.; Amon-Tanoh, M.; Kadjo, C. V., et al. Polycystic Ovary Syndrome (PCOS) an Emerging Risk Factor of Cerebral Venous Sinus Thrombosis (CVST): A Case Report and Literature Review. Clin. Neurol. Neurosci. 2024, 8(4), 54-60. doi: 10.11648/j.cnn.20240804.12
@article{10.11648/j.cnn.20240804.12, author = {Gloire Chubaka Magala and Arlette Désirée Aka and Fiacre Delors Offoumou and Muriel Amon-Tanoh and Cédric Valery Kadjo and Marceline Sifa Balungwe and Abel Christian Tanoh and Constance Yapo-Ehounoud and Mariam Doumbia-Ouattara and Paulette Yapo-Yapi Chia and Évelyne Aka-Anghui Diarra and Berthe Assi}, title = {Polycystic Ovary Syndrome (PCOS) an Emerging Risk Factor of Cerebral Venous Sinus Thrombosis (CVST): A Case Report and Literature Review}, journal = {Clinical Neurology and Neuroscience}, volume = {8}, number = {4}, pages = {54-60}, doi = {10.11648/j.cnn.20240804.12}, url = {https://doi.org/10.11648/j.cnn.20240804.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20240804.12}, abstract = {Cerebral venous sinus thrombosis (CVST) is responsible for about 0.5% to 3% of all strokes, with a markedly higher frequency noted in young women. This condition is determined by several factors; in addition to established risk factors, new contributors that have become better recognized but less well-documented in the tropics include obesity, polycystic ovary syndrome (PCOS), COVID-19 infection, and vaccine-associated thrombocytopenia and thrombosis. We describe the third known case, and the first described in Africa, of CVST in a woman with PCOS and no recognizable pro-thrombotic disorder. A 42-year-old female patient, right-handed, nulligest, and obese presented with a history of infertility and menstrual cycle disorders. She was admitted to our department due to the onset of atypical headaches that progressed subacutely and were associated to generalized tonic-clonic seizures. Neurological assessment upon admission revealed intracranial hypertension syndrome. Brain MRI showed extensive CVST on the left side, involving the lateral sinus and the internal jugular vein. The diagnosis of PCOS was made according to the Rotterdam criteria. A multidisciplinary management strategy was implemented. Comprehensive studies are essential to elucidate the factors associated with CVST in women diagnosed with PCOS, which will facilitate risk assessment and the formulation of preventive measures.}, year = {2024} }
TY - JOUR T1 - Polycystic Ovary Syndrome (PCOS) an Emerging Risk Factor of Cerebral Venous Sinus Thrombosis (CVST): A Case Report and Literature Review AU - Gloire Chubaka Magala AU - Arlette Désirée Aka AU - Fiacre Delors Offoumou AU - Muriel Amon-Tanoh AU - Cédric Valery Kadjo AU - Marceline Sifa Balungwe AU - Abel Christian Tanoh AU - Constance Yapo-Ehounoud AU - Mariam Doumbia-Ouattara AU - Paulette Yapo-Yapi Chia AU - Évelyne Aka-Anghui Diarra AU - Berthe Assi Y1 - 2024/12/23 PY - 2024 N1 - https://doi.org/10.11648/j.cnn.20240804.12 DO - 10.11648/j.cnn.20240804.12 T2 - Clinical Neurology and Neuroscience JF - Clinical Neurology and Neuroscience JO - Clinical Neurology and Neuroscience SP - 54 EP - 60 PB - Science Publishing Group SN - 2578-8930 UR - https://doi.org/10.11648/j.cnn.20240804.12 AB - Cerebral venous sinus thrombosis (CVST) is responsible for about 0.5% to 3% of all strokes, with a markedly higher frequency noted in young women. This condition is determined by several factors; in addition to established risk factors, new contributors that have become better recognized but less well-documented in the tropics include obesity, polycystic ovary syndrome (PCOS), COVID-19 infection, and vaccine-associated thrombocytopenia and thrombosis. We describe the third known case, and the first described in Africa, of CVST in a woman with PCOS and no recognizable pro-thrombotic disorder. A 42-year-old female patient, right-handed, nulligest, and obese presented with a history of infertility and menstrual cycle disorders. She was admitted to our department due to the onset of atypical headaches that progressed subacutely and were associated to generalized tonic-clonic seizures. Neurological assessment upon admission revealed intracranial hypertension syndrome. Brain MRI showed extensive CVST on the left side, involving the lateral sinus and the internal jugular vein. The diagnosis of PCOS was made according to the Rotterdam criteria. A multidisciplinary management strategy was implemented. Comprehensive studies are essential to elucidate the factors associated with CVST in women diagnosed with PCOS, which will facilitate risk assessment and the formulation of preventive measures. VL - 8 IS - 4 ER -