Clinical Neurology and Neuroscience

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Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years

Received: Oct. 03, 2023    Accepted: Oct. 20, 2023    Published: Nov. 09, 2023
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Abstract

Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.

DOI 10.11648/j.cnn.20230704.11
Published in Clinical Neurology and Neuroscience ( Volume 7, Issue 4, December 2023 )
Page(s) 77-81
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Clinical, Electrical, Epilepsies with Centro-Temporal Spikes

References
[1] Anna MB, Ndiaye M, Adjaratou DS, Mamadou MS, Lala BS, Marième SS, et al. Epilepsy with centro-temporal spikes: 105 patients followed at the Neurology department of Dakar (Senegal). Afr Middle East Epilepsy J [online]. 2014.
[2] Beaussart M. Benign epilepsy of children with Rolandic (centro-temporal) paroxysmal foci. A clinical entity. Study of 221 cases. Epilepsy. 1972; 13 (6): 795–811.
[3] Blom S, Heijbel J, Bergfors PG. Benign epilepsy of children with centro-temporal EEG foci. Prevalence and follow-up study of 40 patients. Epilepsy. 1972; 13 (5): 609-619.
[4] Bourrous M, Elibrahimi I, Draiss G, Safini F, Amine M, Bouskraoui M. Characteristics of children with epilepsy followed at the Marrakech University Hospital. Rev Neurol (Paris). 2010; 166 (11): 921-926.
[5] Cavazzuti GB, Cappella L, Nalin A. Longitudinal study of epileptiform EEG patterns in normal children. Epilepsy. 1980; 21 (1): 43-55.
[6] JAMBAQUE I. Cognitive and emotional dysfunctions in non-idiopathic epilepsies. ANAE. 2016; (vol. 28 volume 6 n° 145): 625-634.
[7] Kamoun F, Ayedi I, Hsairi I, Ellouz E, Triki C. Worsening of Central-Temporal Epilepsy by Carbamazepine: Benefit of EEG monitoring. Afr Middle East Epilepsy J [online]. 2013.
[8] Kriz M, Gazdik M. [Epilepsy with centrotemporal (Rolandic) spikes. A peculiar seizure disorder of childhood]. Neurol Neurochir Pol. 1978; 12 (4): 413-419.
[9] Loiseau P, Duché B, Cordova S, Dartigues JF, Cohadon S. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsy. 1988; 29 (3): 229-235.
[10] Malfait D, Lippé S. Cognitive and behavioral disorders in children with benign epilepsy with centro-temporal spikes. Neuropsicol Latinoam. 2011; 3 (1): 47-57.
[11] Massa R, Saint-Martin A de, Rudolf G, Carcangiu R, Seegmuller C, Kleitz C, et al. EEG criteria predictive of cognitive complications in idiopathic focal epilepsy with centro-temporal spikes. Epilepsies. 2001; 13 (2): 81-90.
[12] Masson E. Centrotemporal spike epilepsy in children in Marrakech [online]. EM-Consult.
[13] Masson E. Cohort of 37 cases of benign Rolandic epilepsy followed in epileptology consultation at the University Hospital of Marrakech [online]. EM-Consult.
[14] Saint-Martin AD, Seegmuller C, Carcangiu R, Kleitz C, Hirsch E, Marescaux C, et al. [Cognitive consequences of Rolandic Epilepsy]. Epileptic Disord Int Epilepsy J Videotape. 2001; 3 Spec No 2: SI59-65.
[15] Thiam L, Seck N, Diouf FN, Boiro D, Niang B, Sagna SD, et al. Clinical and paraclinical aspects of childhood epilepsy at the Peace Hospital of Ziguinchor: documentary study. Pan Afr Med J. 2020; 37: 387.
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    Modji Basse, A., Joubaily, Z., Mpung Mansoj, H., Dieynabou Sow, A., Emilie Ndong, M., et al. (2023). Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years. Clinical Neurology and Neuroscience, 7(4), 77-81. https://doi.org/10.11648/j.cnn.20230704.11

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    ACS Style

    Modji Basse, A.; Joubaily, Z.; Mpung Mansoj, H.; Dieynabou Sow, A.; Emilie Ndong, M., et al. Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years. Clin. Neurol. Neurosci. 2023, 7(4), 77-81. doi: 10.11648/j.cnn.20230704.11

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    AMA Style

    Modji Basse A, Joubaily Z, Mpung Mansoj H, Dieynabou Sow A, Emilie Ndong M, et al. Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years. Clin Neurol Neurosci. 2023;7(4):77-81. doi: 10.11648/j.cnn.20230704.11

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  • @article{10.11648/j.cnn.20230704.11,
      author = {Anna Modji Basse and Zeina Joubaily and Halladain Mpung Mansoj and Adjaratou Dieynabou Sow and Marie Emilie Ndong and Seynabou Dieng and Lala Bouna Seck and Moustapha Ndiaye and Amamdou Gallo Diop},
      title = {Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years},
      journal = {Clinical Neurology and Neuroscience},
      volume = {7},
      number = {4},
      pages = {77-81},
      doi = {10.11648/j.cnn.20230704.11},
      url = {https://doi.org/10.11648/j.cnn.20230704.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cnn.20230704.11},
      abstract = {Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years
    AU  - Anna Modji Basse
    AU  - Zeina Joubaily
    AU  - Halladain Mpung Mansoj
    AU  - Adjaratou Dieynabou Sow
    AU  - Marie Emilie Ndong
    AU  - Seynabou Dieng
    AU  - Lala Bouna Seck
    AU  - Moustapha Ndiaye
    AU  - Amamdou Gallo Diop
    Y1  - 2023/11/09
    PY  - 2023
    N1  - https://doi.org/10.11648/j.cnn.20230704.11
    DO  - 10.11648/j.cnn.20230704.11
    T2  - Clinical Neurology and Neuroscience
    JF  - Clinical Neurology and Neuroscience
    JO  - Clinical Neurology and Neuroscience
    SP  - 77
    EP  - 81
    PB  - Science Publishing Group
    SN  - 2578-8930
    UR  - https://doi.org/10.11648/j.cnn.20230704.11
    AB  - Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.
    
    VL  - 7
    IS  - 4
    ER  - 

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Author Information
  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Department of Neurology, Fann National Teaching Hospital, Dakar, Senegal

  • Section