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Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh

Received: 16 May 2024    Accepted: 31 May 2024    Published: 19 June 2024
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Abstract

Background: Appendicular mass, a common occurrence in acute appendicitis (10% of cases), develops within 24-48 hours of symptom onset. Management strategies, including early appendectomy, non-operative management with or without drainage, and interval appendectomy, vary widely. This study aims to evaluate the outcomes of early surgical management and compare different surgical approaches. Methodology: This retroospective observational study was performed in different private and government hospital at Jamalpur, Manikgonj for a period of 8 years from January 2015 to December 2022. A total of 288 consecutive patients meeting eligibility criteria underwent open appendectomy within 24 hours of hospital admission due to appendicular lump diagnosis based on clinical or ultrasonographic findings. Two surgical techniques were employed: appendicectomy with generalized peritoneal toileting and appendicectomy with loco-regional peritoneal toileting All data were collected from hospital records. Follow-up records for a period of 2 weeks and at the end of 1 year were reviewed. Results: Patients had a mean age of 30.04 years, mostly male and under 30 years old. Appendicular lump with abscess was predominant (73.96%), along with perforated appendix and presence of pus (71.18% and 75.35% respectively). 68.75% underwent appendicectomy with loco-regional toileting, and 31.25% with generalized peritoneal toileting. Both groups were similar in demographics and perioperative findings, with common difficulties in localization and dissection (76.79% and 88.89% respectively). No bowel injuries occurred in the loco-regional toileting group. Postoperative complications were significantly lower in this group, especially superficial and deep wound infections (11.61% vs 16.67%, 2.53% vs 10%). Fecal fistula and incisional hernia were observed in the generalized peritoneal toileting group (1.11%, 2.22%). Operative time was notably shorter in the loco-regional peritoneal toileting group (92 minutes vs 65 minutes) Conclusion: Early appendicectomy allows for single-admission treatment, serving as an effective alternative to conservative therapy by significantly reducing hospital stays and expenses. Specifically, early appendicectomy with loco-regional peritoneal toileting demonstrates shorter operative times and lower post-operative complications compared to generalized peritoneal toileting, suggesting its favorable utility in managing appendicular mass and warranting further optimization in surgical strategies.

Published in Clinical Medicine Research (Volume 13, Issue 3)
DOI 10.11648/j.cmr.20241303.12
Page(s) 33-38
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Early Surgery, Appendicular Mass, Loco-regional Peritoneal Toileting, Generalized Peritoneal Toileting, Bangladesh

1. Introduction
Acute appendicitis, a prevalent acute abdominal condition in surgical practice, often manifests as an appendicular mass, constituting up to 10% of cases . This condition, ranging from phlegmon to abscess formation, develops within 24 to 48 hours of symptom onset, comprising the inflamed appendix, omentum, and bowel loops as a protective mechanism against infection spread . Despite its frequent occurrence, the management of appendicular mass remains controversial over decades. It constitutes a significant portion of acute surgical abdomen cases in children, with 10% of acute appendicitis cases presenting as appendicular mass, and a notable percentage involving perforation . Treatment strategies vary widely, with approaches encompassing early appendectomy, non-operative management with or without percutaneous drainage, and interval appendectomy. Conservative management with interval appendectomy, advocated since the early 1900s, remains widely practiced, while the emerging trend towards omitting interval appendectomy challenges established norms due to low infection and recurrence rates. There are contradicting evidences to prove superiority of one over another. With conservative treatment being the favored option, the debate over the necessity of interval appendectomy persists, driven by considerations of recurrence risk and post-treatment outcomes .
Traditionally, conservative management followed by interval appendicectomy 4 to 6 weeks later has been the standard approach for patients with appendicular mass. This strategy aims to mitigate the perceived risks associated with early appendicectomy, including potential complications such as fecal fistula, which are considered hazardous and time-consuming. However, proponents of immediate appendicectomy argue for a definitive operative intervention during the initial admission. Studies supporting immediate appendicectomy suggest advantages such as expedited recovery and complete resolution within the same admission, thus reducing the need for subsequent readmission for interval appendicectomy and promptly excluding other pathologies . Therefore, our study aims to observe the outcome of early surgical management of appendicular mass and to compare between different surgical approaches practiced.
2. Methodology
In this retrospective Cross sectional study, we reviewed the cases of 288 patients with appendicular mass who underwent early appendectomy within an 8-year period from January 2015 to December 2022 at the Department of General Surgery, Manikgonj Sadar Hospital, Manikgonj, Dhaka. Early appendectomy was defined as the surgical removal of the appendix within 24 hours of admission and within 14 days of the onset of an acute appendicitis attack. Diagnosis of appendicular mass was established clinically, through ultrasonography, or during surgical exploration. Patients with a lump in the right iliac fossa due to worm bolus, ileo-caecal tuberculosis, or carcinoid tumor were excluded from the study. Additionally, patients with contraindications to surgery or incomplete medical records were also excluded. All patients underwent laparotomy, with the operative approach being a lower right paramedian incision. Two types of operative procedures were performed: laparotomy followed by appendicectomy with generalized peritoneal toileting in 90 patients, and laparotomy followed by appendicectomy with local peritoneal toileting in 198 patients. Data collection involved reviewing medical records for demographic information, indications for surgery, surgical procedures performed, and postoperative outcomes. Surgical outcomes, including postoperative complications, length of hospital stay, and postoperative pain assessment, were evaluated as dependent variables. Follow-up records for a period of 2 weeks were reviewed, and patients were also assessed for late complications such as incisional hernia at 1 year. Statistical analysis included descriptive statistics to summarize patient characteristics, and inferential statistics were used to compare outcomes between the two surgical approaches performed. Categorical variables were described in terms of frequency and percentage, while continuous variables were expressed as mean ± standard deviation or median. Student's t-test and the chi-squared test were conducted using STATA version 17, with the level of significance set at 5% (P < 0.05).
Table 1. Baseline characteristics of patients.

Variables

Frequency (n=288)

Percentage

Age category

0-10

19

6.60

11-20

64

22.22

21-30

97

33, 68

31-40

53

18.40

41-50

53

11.46

>50

22

7.64

Gender

Male

160

55.56

Female

128

44.44

Mean age: 30.04± 14.34 SD

Table 2. Per operative findings of patients.

Diagnosis

Frequency

Percentage

Appendicular lump

69

23.96

Appendicular abcess

03

1.04

Appendicular lump with abcess

213

73.96

Appendicular lump with abcess with left ovarian cyst

1

0.35

Appendicular lump with purulent peritonitis

1

0.35

Appendicular lump with sloughing of Caecum

1

0.35

Per operative Appendix condition

Perforated

205

71.18

Phlegnomous

156

54.17

Gangrenous

08

2.78

Presence of pus

217

75.35

Figure 1. Patient distribution by operative technique.
Figure 2. Distribution of post-operative complications among patients.
Table 3. Operative findings of two groups.

Variables

Appendicectomy and generalized peritoneal toileting (n=90) N (%)

Appendicectomy with loco-regional peritoneal toileting (n=198) N (%)

P-value

Mean age ± SD

29.04±10.12

31.23± 9.15

0.64

Operative findings

Simple mass

21 (23.33%)

59 (29.80)

Pus collection

60 (66.67%)

120 (60.68)

.049

Appendicular abcess

09 (10%)

19 (9.60)

Operative Complication

Difficulty in localization of appendix

83 (92.22%)

189 (95.45)

Difficulty in dissection

69 (76.67%)

176 (88.89)

Bleeding

5 (5.56%)

27 (13.64)

.071

Adjacent bowel injury

01 (1.11%)

00 (0.00)

Need to extend incision

8 (8.89%)

13 (6.57)

Mean Operative time (minutes)

92

65

.023

Table 4. Distribution of post-operative complication between two groups.

Post-operative complication

Appendicectomy and generalized peritoneal toileting (n=90) N (%)

Appendicectomy with loco-regional peritoneal toileting (n=198) N (%)

P-value

Superficial wound infection

15 (16.67)

23 (11.61)

Deep wound infection

09 (10)

05 (2.53)

Residual Abcess

00 (00)

02 (1.01)

.038

Intestinal/Fecal fistula

01 (1.11)

00 (00)

Incisional Hernia

02 (2.22)

00 (00)

3. Results
Among 288 patients with appendicular lump, nearly two-third patients (61.3%) admitted with appendicular lump were below 30 years of age and only 7.6% were above 50 years of age. Children below 10 and elderly frequency of lump formation was less. The mean age of patient was 30.04 years with male predominance.
Among all the patient with abdominal lump, per operative; the most common diagnosis is appendicular lump with abscess, accounting for 73.96% of cases. One patient had appendicular lump with sloughing out of caecum and another one patient with appendicular lump and purulent peritonitis. Perforated appendices and presence of pus were the most prevalent, representing 71.18% and 75.35% of cases respectively. Only 2.78% had gangrenous appendix.
Post-operatively, superficial wound infection developed in 13.19% patients whereas only 4.86% had deep wound infection. Only one patient experienced fecal fistula and unfortunately this patient had per-operative sloughed out caecum. Incisional hernia was reported in one patient during 1 year follow up.
During operation, we followed two techniques, 68.75%(198 cases) underwent appendicectomy with loco-regional peritoneal toileting and 31.25% patients (90 cases) underwent appendicectomy with generalized peritoneal toileting. In the first two years of the study period, appendicectomy with generalized peritoneal toileting was performed in nearly all patients and later on loco-regional peritoneal toileting was preferred by the surgeon.
Based on the appendicectomy technique. Mean age was slightly higher in loco regional toileting group (31.04 vs 29.23 year) although the association was not statistically significant. Localization of appendix and surgical dissection was difficult in majority of the cases in both technniques (76.69-88.89%). No adjacent bowel injury happened in loco-regional toileting group whreas one patient had bowel injury in generalized peritoneal toileting group. Mean operation time was significantly lower in loco-regional toileting group (92 minutes’ vs 65 minutes.
Comparing the post- operative complication between two groups, overall complication rate was hoigher in patients undergoing appendicectomy with generalized peritoneal toileting Superficial wound infection and deep wound infection rate were lower in loco-regional toileting group . Residual abcess developed in 2 patients in loco-regional toileting group but no fecal fistula or intestinal hernia recorded in this group.
4. Discussion
Appendiceal mass formation typically arises from appendiceal wall perforation . Three management approaches exist: emergency surgery, conservative management followed by interval surgery, and entirely conservative management without interval surgery . This study emphasizes early surgery to reduce repeat consultations and hospital admissions, alleviate patient suffering, and promote early recovery.
Among 288 patients, the majority of patients (33.68%) fall within the age range of 21-30 years, with male predominancel. The mean age of the patients is 30.04 years, with a standard deviation of 14.34 years. similar observations were encountered by study carried by Patel BJ and Gilker I A et al . But Rahman, M. A. M., Chowdhury found that majorituy of the patients were below 12 years of age , this may be due to the fact that the study hoapital was paediatrics based hospital, therefore less adult attendance.
The most common diagnosis in the index study was appendicular lump with abscess, accounting for 73.96% of cases. Perforated appendices are the most prevalent, representing 71.18% of cases. Appendicular lump with presence of pus was also the predominant findings by Rahman, M. A. M., Chowdhury et al . MA. Bahram also found All patients had a fixed appendicular mass with peri-appendiceal abscesses and adhesions which strongly supports our study .
During the operation, two techniques were employed: 68.75% (198 cases) underwent appendicectomy with loco-regional peritoneal toileting, while 31.25% (90 cases) underwent appendicectomy with generalized peritoneal toileting. Initially, during the first two years of the study, almost all patients underwent appendicectomy with generalized peritoneal toileting, but later in the study period, the surgeon preferred loco-regional peritoneal toileting. All 288 operations were performed by the principal author of this study by himself. The loco-regional toileting during appendicectomy was a new techniques employed by the surgeon based on her operative experience as this technique involes less operative time, less handling and lower post-operative complications. All these were the observation of surgeon himself; therefore, further study involving this method is required to establish it benefits over the widely practiced generalized peritoneal toileting method.
The index study compares the operative findings of two groups based on the type of appendicectomy performed. There is no significant difference in mean age between patients undergoing different surgical approaches. However, there is a significant difference in the frequency of pus collection, with a higher incidence observed in patients undergoing appendicectomy with generalized peritoneal toileting. Although not statistically significant, there is a trend towards higher rates of bleeding in patients undergoing appendicectomy with loco-regional peritoneal toileting. Additionally, patients undergoing appendicectomy with generalized peritoneal toileting had a significantly longer mean operative time compared to those with loco-regional peritoneal toileting.
Gilkar IA also recorded the above mentioned complication after early surgery but the complication rates were than loco-regional toileting group and comparable with generalized peritoneal toileting group which supports the superiority of loco-regional toileting . E. S. Garba's observations, the emergency group experienced higher rates of both operative and post-operative complications compared to the other group, where they noted a complication rate of approximately 36%, comparable to that of perforated appendicitis. Immediate surgery increases the risk of infection dissemination and intestinal fistula formation, potentially negating the anticipated benefits but in our study the complication rates were comparably lower and no fecal fistulaa or incisional hernia recorded.
This study showed the distribution of postoperative complications between the two groups. The incidence of superficial wound infection and deep wound infection was slightly higher in patients undergoing appendicectomy with generalized peritoneal toileting, although not statistically significant. However, there is a significant difference in the incidence of residual abscess between the two groups, with a higher rate observed in patients undergoing appendicectomy with loco-regional peritoneal toileting. Additionally, two cases of incisional hernia were reported in patients who underwent appendicectomy with generalized peritoneal toileting. Ali et al. found emergency appendectomy to be a safe, cost-effective alternative to conservative management for appendicular mass. Khan et al. conducted trials on 300 patients, with immediate appendectomy showing lower wound infection rates (5% vs. 8%) and less than 2% intra-abdominal abscess frequency. Arshad et al.'s comparative study on 176 patients favored immediate appendectomy despite higher infection rates, citing shorter hospital stays . All these study findings support the index study.
Considering the operative duration and post-operative complications, the loco-regional peritoneal toileting group shows favourable outcomes than the traditional generalized peritoneal toileting group. This suggests that the surgeons can adopt this technique for better operative outcome and patients benefits.
Strengths of this study include its large sample size, comprehensive data collection spanning an 8-year period, and focus on early appendectomy for appendicular mass. Additionally, the inclusion of both perioperative and postoperative outcomes enhances the robustness of the findings. However, limitations include its retrospective design, which may introduce bias, as well as the potential for incomplete medical records and variability in surgical techniques over time. Further prospective studies are warranted to validate the observed associations and optimize treatment strategies for appendicular mass.
5. Conclusions
This retrospective study of 288 patients undergoing early appendectomy for appendicular mass found a predominance of cases below 30 years of age and a male bias. The most common diagnosis was appendicular lump with abscess. Loco-regional peritoneal toileting was the preferred surgical approach, showing potential benefits such as shorter operation times and possibly lower rates of wound infections compared to generalized peritoneal toileting. Further research is needed to confirm these findings and optimize treatment strategies.
Abbreviations

STATA

Statistical Software for Data Science

Author Contributions
Jahangir Md Sarwar: Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing
Abul Kalam Md Shamsuddin: Writing – original draft, Writing – review & editing
Sirajam Munira: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Conflicts of Interest
The authors declare no conflicts of interest.
References
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  • APA Style

    Sarwar, J. M., Shamsuddin, A. K. M., Munira, S. (2024). Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh. Clinical Medicine Research, 13(3), 33-38. https://doi.org/10.11648/j.cmr.20241303.12

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    Sarwar, J. M.; Shamsuddin, A. K. M.; Munira, S. Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh. Clin. Med. Res. 2024, 13(3), 33-38. doi: 10.11648/j.cmr.20241303.12

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    AMA Style

    Sarwar JM, Shamsuddin AKM, Munira S. Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh. Clin Med Res. 2024;13(3):33-38. doi: 10.11648/j.cmr.20241303.12

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  • @article{10.11648/j.cmr.20241303.12,
      author = {Jahangir Md Sarwar and Abul Kalam Md Shamsuddin and Sirajam Munira},
      title = {Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh
    },
      journal = {Clinical Medicine Research},
      volume = {13},
      number = {3},
      pages = {33-38},
      doi = {10.11648/j.cmr.20241303.12},
      url = {https://doi.org/10.11648/j.cmr.20241303.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241303.12},
      abstract = {Background: Appendicular mass, a common occurrence in acute appendicitis (10% of cases), develops within 24-48 hours of symptom onset. Management strategies, including early appendectomy, non-operative management with or without drainage, and interval appendectomy, vary widely. This study aims to evaluate the outcomes of early surgical management and compare different surgical approaches. Methodology: This retroospective observational study was performed in different private and government hospital at Jamalpur, Manikgonj for a period of 8 years from January 2015 to December 2022. A total of 288 consecutive patients meeting eligibility criteria underwent open appendectomy within 24 hours of hospital admission due to appendicular lump diagnosis based on clinical or ultrasonographic findings. Two surgical techniques were employed: appendicectomy with generalized peritoneal toileting and appendicectomy with loco-regional peritoneal toileting All data were collected from hospital records. Follow-up records for a period of 2 weeks and at the end of 1 year were reviewed. Results: Patients had a mean age of 30.04 years, mostly male and under 30 years old. Appendicular lump with abscess was predominant (73.96%), along with perforated appendix and presence of pus (71.18% and 75.35% respectively). 68.75% underwent appendicectomy with loco-regional toileting, and 31.25% with generalized peritoneal toileting. Both groups were similar in demographics and perioperative findings, with common difficulties in localization and dissection (76.79% and 88.89% respectively). No bowel injuries occurred in the loco-regional toileting group. Postoperative complications were significantly lower in this group, especially superficial and deep wound infections (11.61% vs 16.67%, 2.53% vs 10%). Fecal fistula and incisional hernia were observed in the generalized peritoneal toileting group (1.11%, 2.22%). Operative time was notably shorter in the loco-regional peritoneal toileting group (92 minutes vs 65 minutes) Conclusion: Early appendicectomy allows for single-admission treatment, serving as an effective alternative to conservative therapy by significantly reducing hospital stays and expenses. Specifically, early appendicectomy with loco-regional peritoneal toileting demonstrates shorter operative times and lower post-operative complications compared to generalized peritoneal toileting, suggesting its favorable utility in managing appendicular mass and warranting further optimization in surgical strategies.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Early Surgical Management of Appendicular Mass: Evaluation of Surgical Outcome in Selected Private and Government Hospitals, Bangladesh
    
    AU  - Jahangir Md Sarwar
    AU  - Abul Kalam Md Shamsuddin
    AU  - Sirajam Munira
    Y1  - 2024/06/19
    PY  - 2024
    N1  - https://doi.org/10.11648/j.cmr.20241303.12
    DO  - 10.11648/j.cmr.20241303.12
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 33
    EP  - 38
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20241303.12
    AB  - Background: Appendicular mass, a common occurrence in acute appendicitis (10% of cases), develops within 24-48 hours of symptom onset. Management strategies, including early appendectomy, non-operative management with or without drainage, and interval appendectomy, vary widely. This study aims to evaluate the outcomes of early surgical management and compare different surgical approaches. Methodology: This retroospective observational study was performed in different private and government hospital at Jamalpur, Manikgonj for a period of 8 years from January 2015 to December 2022. A total of 288 consecutive patients meeting eligibility criteria underwent open appendectomy within 24 hours of hospital admission due to appendicular lump diagnosis based on clinical or ultrasonographic findings. Two surgical techniques were employed: appendicectomy with generalized peritoneal toileting and appendicectomy with loco-regional peritoneal toileting All data were collected from hospital records. Follow-up records for a period of 2 weeks and at the end of 1 year were reviewed. Results: Patients had a mean age of 30.04 years, mostly male and under 30 years old. Appendicular lump with abscess was predominant (73.96%), along with perforated appendix and presence of pus (71.18% and 75.35% respectively). 68.75% underwent appendicectomy with loco-regional toileting, and 31.25% with generalized peritoneal toileting. Both groups were similar in demographics and perioperative findings, with common difficulties in localization and dissection (76.79% and 88.89% respectively). No bowel injuries occurred in the loco-regional toileting group. Postoperative complications were significantly lower in this group, especially superficial and deep wound infections (11.61% vs 16.67%, 2.53% vs 10%). Fecal fistula and incisional hernia were observed in the generalized peritoneal toileting group (1.11%, 2.22%). Operative time was notably shorter in the loco-regional peritoneal toileting group (92 minutes vs 65 minutes) Conclusion: Early appendicectomy allows for single-admission treatment, serving as an effective alternative to conservative therapy by significantly reducing hospital stays and expenses. Specifically, early appendicectomy with loco-regional peritoneal toileting demonstrates shorter operative times and lower post-operative complications compared to generalized peritoneal toileting, suggesting its favorable utility in managing appendicular mass and warranting further optimization in surgical strategies.
    
    VL  - 13
    IS  - 3
    ER  - 

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