Research Article | | Peer-Reviewed

Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents

Received: 14 July 2023     Accepted: 16 August 2023     Published: 8 January 2024
Views:       Downloads:
Abstract

Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.

Published in Clinical Medicine Research (Volume 13, Issue 1)
DOI 10.11648/j.cmr.20241301.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hydro Alcoholic Extract (Withania Coagulans), Furosemide, Active Diurnal, Urinary Output

References
[1] Adomako, E. A., & Sambandam, K. K. (2022). Challenges in diuretic therapy: A case-based discussion. The American Journal of the Medical Sciences.
[2] Vazir, A., & Cowie, M. R. (2013). The use of diuretics in acute heart failure: Evidence based therapy?
[3] Dutta, K. N., Chetia, P., Lahkar, S., & Das, S. (2014). Herbal plants used as diuretics: a comprehensive review. J Pharm Chem Biol Sci, 2 (1), 27–32.
[4] Brater, D. C. (2000). Pharmacology of diuretics. The American Journal of the Medical Sciences, 319 (1), 38–50.
[5] Suri, S. S., & Pamboukian, S. V. (2021). Optimal diuretic strategies in heart failure. Annals of Translational Medicine, 9 (6).
[6] Gupta, V. K., & Arya, V. (2011). A review on potential diuretics of Indian medicinal plants. J Chem Pharm Res, 3 (1), 613–620.
[7] Gupta, P. C. (2012). Withania coagulans Dunal-an overview. International Journal of Pharmaceutical Sciences Review and Research, 12 (2), 68–71.
[8] Mathur, D., Agrawal, R. C., & Shrivastava, V. (2011). Phytochemical screening and determination of antioxidant potential of fruits extracts of Withania coagulans. Recent Research in Science and Technology, 3 (11), 26–29.
[9] de Oliveira, P. B., Silva, M. J., Ferreira, R. B., Oliveira, C. M., & Monteiro, A. A. (2007). Dry matter partitioning, carbohydrate composition, protein reserves, and fruiting in ‘Autumn Bliss’ red raspberry vary in response to pruning date and cane density. HortScience, 42 (1), 77–82.
[10] Leigh, M. B., Fletcher, J. S., Fu, X., & Schmitz, F. J. (2002). Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants. Environmental Science & Technology, 36 (7), 1579–1583.
[11] Meher SK, Das B, Panda P, Bhuyan GC, Rao MM. Uses of Withania somnifera (Linn) Dunal (Ashwagandha) in Ayurveda and its pharmacological evidences. Research Journal of Pharmacology and Pharmacodynamics. 2016; 8(1): 23-9.
[12] Hemalatha, S., Kumar, R., & Kumar, M. (2008). Withania coagulans Dunal: A review. Pharmacognosy Reviews, 2 (4), 351.
[13] Ahmed, A. (2009). DEFEAT–Heart Failure: a guide to management of geriatric heart failure by generalist physicians. Minerva Medica, 100 (1), 39.
[14] Almalki, W. H. (2023). Mechanism on the action of drugs for heart failure. In How Synthetic Drugs Work (pp. 275–288). Elsevier.
[15] Wiig, H., Luft, F. C., & Titze, J. M. (2018). The interstitium conducts extrarenal storage of sodium and represents a third compartment essential for extracellular volume and blood pressure homeostasis. Acta Physiologica, 222 (3), e13006.
[16] Yadav, R. N. S., & Agarwala, M. (2011). Phytochemical analysis of some medicinal plants. Journal of Phytology, 3 (12).
[17] Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009). Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules, 14 (7), 2373–2393.
Cite This Article
  • APA Style

    Sharma, R. K., Chandolia, P., Sundram, R. S., Isha, K., Soni, S. (2024). Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clinical Medicine Research, 13(1), 1-5. https://doi.org/10.11648/j.cmr.20241301.11

    Copy | Download

    ACS Style

    Sharma, R. K.; Chandolia, P.; Sundram, R. S.; Isha, K.; Soni, S. Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clin. Med. Res. 2024, 13(1), 1-5. doi: 10.11648/j.cmr.20241301.11

    Copy | Download

    AMA Style

    Sharma RK, Chandolia P, Sundram RS, Isha K, Soni S. Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clin Med Res. 2024;13(1):1-5. doi: 10.11648/j.cmr.20241301.11

    Copy | Download

  • @article{10.11648/j.cmr.20241301.11,
      author = {Rajesh Kumar Sharma and Priyanka Chandolia and Ravi Shankar Sundram and Kumari Isha and Sanjana Soni},
      title = {Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents},
      journal = {Clinical Medicine Research},
      volume = {13},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.cmr.20241301.11},
      url = {https://doi.org/10.11648/j.cmr.20241301.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241301.11},
      abstract = {Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.
    },
     year = {2024}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents
    AU  - Rajesh Kumar Sharma
    AU  - Priyanka Chandolia
    AU  - Ravi Shankar Sundram
    AU  - Kumari Isha
    AU  - Sanjana Soni
    Y1  - 2024/01/08
    PY  - 2024
    N1  - https://doi.org/10.11648/j.cmr.20241301.11
    DO  - 10.11648/j.cmr.20241301.11
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20241301.11
    AB  - Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.
    
    VL  - 13
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Pharmacology, NIMS Institute of Pharmacy, Nims University, Jaipur, India

  • Department of Pharmacology, NIMS Institute of Pharmacy, Nims University, Jaipur, India

  • Department of Pharmacy, NIMS Institute of Pharmacy, Nims University, Jaipur, India

  • Department of Pharmacy, NIMS Institute of Pharmacy, Nims University, Jaipur, India

  • Department of Pharmacy Practice, NIMS Institute of Pharmacy, Nims University, Jaipur, India

  • Sections