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Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells

Received: 11 July 2021     Accepted: 26 July 2021     Published: 2 August 2021
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Abstract

Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, p<0.0001). RR showed a statistically significant and positive association with COVID-19 severity for WBC (RR=45.2); neutrophil/lymphocyte ratio (NLR) (RR=3.8); IL-6 (RR=1.6); lymphocyte/monocyte ratio (LMR) (RR=1.5); and RR=1.3 for platelets/lymphocyte ratio (PLR), ferritin, and LDH. Conclusions: Risk assessment of severity using this laboratory variable is important.

Published in Clinical Medicine Research (Volume 10, Issue 4)
DOI 10.11648/j.cmr.20211004.15
Page(s) 133-141
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

COVID-19, SARS-CoV-2, Clinical Decision-Making, Risk Assessment, Risk Factors, Prognosis, IL-6, LDH

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    Rivero-Jimenez Rene Antonio, Villegas-Valverde Carlos Agustin, Torres-Zambrano Gina Marcela, Abdelrazik Abeer, Haider Muhammad Touseef, et al. (2021). Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clinical Medicine Research, 10(4), 133-141. https://doi.org/10.11648/j.cmr.20211004.15

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    ACS Style

    Rivero-Jimenez Rene Antonio; Villegas-Valverde Carlos Agustin; Torres-Zambrano Gina Marcela; Abdelrazik Abeer; Haider Muhammad Touseef, et al. Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clin. Med. Res. 2021, 10(4), 133-141. doi: 10.11648/j.cmr.20211004.15

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    AMA Style

    Rivero-Jimenez Rene Antonio, Villegas-Valverde Carlos Agustin, Torres-Zambrano Gina Marcela, Abdelrazik Abeer, Haider Muhammad Touseef, et al. Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clin Med Res. 2021;10(4):133-141. doi: 10.11648/j.cmr.20211004.15

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  • @article{10.11648/j.cmr.20211004.15,
      author = {Rivero-Jimenez Rene Antonio and Villegas-Valverde Carlos Agustin and Torres-Zambrano Gina Marcela and Abdelrazik Abeer and Haider Muhammad Touseef and Castillo-Aleman Yandy Marx and Ventura-Carmenate Yendry and Abdel Hadi Loubna and Bencomo-Hernandez Antonio Alfonso},
      title = {Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells},
      journal = {Clinical Medicine Research},
      volume = {10},
      number = {4},
      pages = {133-141},
      doi = {10.11648/j.cmr.20211004.15},
      url = {https://doi.org/10.11648/j.cmr.20211004.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211004.15},
      abstract = {Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, pConclusions: Risk assessment of severity using this laboratory variable is important.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells
    AU  - Rivero-Jimenez Rene Antonio
    AU  - Villegas-Valverde Carlos Agustin
    AU  - Torres-Zambrano Gina Marcela
    AU  - Abdelrazik Abeer
    AU  - Haider Muhammad Touseef
    AU  - Castillo-Aleman Yandy Marx
    AU  - Ventura-Carmenate Yendry
    AU  - Abdel Hadi Loubna
    AU  - Bencomo-Hernandez Antonio Alfonso
    Y1  - 2021/08/02
    PY  - 2021
    N1  - https://doi.org/10.11648/j.cmr.20211004.15
    DO  - 10.11648/j.cmr.20211004.15
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 133
    EP  - 141
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20211004.15
    AB  - Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, pConclusions: Risk assessment of severity using this laboratory variable is important.
    VL  - 10
    IS  - 4
    ER  - 

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Author Information
  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Clinical Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Clinical Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Clinical Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

  • Stem Cells Processing Laboratory Department, Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates

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