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A 5-year Follow-up of Subjects with Fasting Plasma Glucose Above 5.6 mmol/l Found in a Screening Study of the Bulgarian Population

Received: 22 May 2021     Accepted: 9 June 2021     Published: 16 June 2021
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Abstract

The WHO and many other diabetes organizations recommend performing OGTT at fasting plasma glucose ≥ 6.1 ÷ 6.9 mmol/L mmol/L, but ADA indicates a lower cut-off for this parameter - ≥ 5.6 ÷ 6.0 mmol/L mmol/L. Aim: We decided to evaluate the role of baseline glucose tolerance for the development of Diabetes or Prediabetes over time by a prospective study of the changes in glucose tolerance 5 years after the last nationwide cross-sectional study in Bulgaria. Material: The study included 204 subjects from a total of 2033 tested 5 years ago. These 204 individuals were selected among those with a fasting plasma glucose (FPG) 6.1 – 6.9 mmol/L (Group 1) and FPG ≥ 5.6 ÷ 6.0 mmol/L (Group 2) found during the screening in 2012. As a part of the screening in 2017, a standard OGTT was performed (WHO’1999) and HbA1c was determined. Methods: Plasma glucose was measured in all the studies by an automated glucose-oxidase analyzer (Glucose Analyzer II, Beckman Coulter, Inc). HbA1c was determined by immunoturbidimetric method after hemolysis of a whole blood sample. Results: Half of the subjects with FPG 6.1 - 6.9 mmol/L in 2012 had Diabetes during the follow up, 31% remained in the Prediabetes group and 19% had Normal glucose tolerance (NGT) in 2017. Among the subjects with FPG ≥ 5.6 - 6.0 mmol/L in 2012, 24.7% had Diabetes in 2017, 34.6% - Prediabetes and 40.7% had NGT. The difference in the Diabetes prevalence between the two groups was significant – 50% vs. 24.7% (T=2.443, P < 0.02). In 5 years’time, 29.9% of the Individuals who had FPG ≥ 5.6 - 6.9 mmol/L in 2012, became Diabetics, 33.6% became Prediabetics and only 36.3% had NGT. In 57% (35/61) of the diabetics the disease was newly diagnosed and in about 2/3 of the cases it was decompensated (HbA1c ≥ 7%). During the 5-year period, Diabetes was diagnosed in 26 (42.6%) persons and 34.6% of them were in metabolic decompensation under treatment. Conclusion: The most important conclusion from our screening from 2017 is that ¼ people with FPG ≥ 5.6 – 6.0 mmol/L after a few years became diabetics, so systematic efforts should be directed towards this border group.

Published in Clinical Medicine Research (Volume 10, Issue 3)
DOI 10.11648/j.cmr.20211003.15
Page(s) 95-101
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

FPG over 6.1 mmol/L, FPG over 5.6 mmol/L, Risk of Diabetes, Risk of Prediabetes

References
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    Anna-Maria Borissova, Jordan Vlahov, Alexander Shinkov, Lilia Dakovska, Boyana Trifonova. (2021). A 5-year Follow-up of Subjects with Fasting Plasma Glucose Above 5.6 mmol/l Found in a Screening Study of the Bulgarian Population. Clinical Medicine Research, 10(3), 95-101. https://doi.org/10.11648/j.cmr.20211003.15

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    ACS Style

    Anna-Maria Borissova; Jordan Vlahov; Alexander Shinkov; Lilia Dakovska; Boyana Trifonova. A 5-year Follow-up of Subjects with Fasting Plasma Glucose Above 5.6 mmol/l Found in a Screening Study of the Bulgarian Population. Clin. Med. Res. 2021, 10(3), 95-101. doi: 10.11648/j.cmr.20211003.15

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    AMA Style

    Anna-Maria Borissova, Jordan Vlahov, Alexander Shinkov, Lilia Dakovska, Boyana Trifonova. A 5-year Follow-up of Subjects with Fasting Plasma Glucose Above 5.6 mmol/l Found in a Screening Study of the Bulgarian Population. Clin Med Res. 2021;10(3):95-101. doi: 10.11648/j.cmr.20211003.15

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  • @article{10.11648/j.cmr.20211003.15,
      author = {Anna-Maria Borissova and Jordan Vlahov and Alexander Shinkov and Lilia Dakovska and Boyana Trifonova},
      title = {A 5-year Follow-up of Subjects with Fasting Plasma Glucose Above 5.6 mmol/l Found in a Screening Study of the Bulgarian Population},
      journal = {Clinical Medicine Research},
      volume = {10},
      number = {3},
      pages = {95-101},
      doi = {10.11648/j.cmr.20211003.15},
      url = {https://doi.org/10.11648/j.cmr.20211003.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211003.15},
      abstract = {The WHO and many other diabetes organizations recommend performing OGTT at fasting plasma glucose ≥ 6.1 ÷ 6.9 mmol/L mmol/L, but ADA indicates a lower cut-off for this parameter - ≥ 5.6 ÷ 6.0 mmol/L mmol/L. Aim: We decided to evaluate the role of baseline glucose tolerance for the development of Diabetes or Prediabetes over time by a prospective study of the changes in glucose tolerance 5 years after the last nationwide cross-sectional study in Bulgaria. Material: The study included 204 subjects from a total of 2033 tested 5 years ago. These 204 individuals were selected among those with a fasting plasma glucose (FPG) 6.1 – 6.9 mmol/L (Group 1) and FPG ≥ 5.6 ÷ 6.0 mmol/L (Group 2) found during the screening in 2012. As a part of the screening in 2017, a standard OGTT was performed (WHO’1999) and HbA1c was determined. Methods: Plasma glucose was measured in all the studies by an automated glucose-oxidase analyzer (Glucose Analyzer II, Beckman Coulter, Inc). HbA1c was determined by immunoturbidimetric method after hemolysis of a whole blood sample. Results: Half of the subjects with FPG 6.1 - 6.9 mmol/L in 2012 had Diabetes during the follow up, 31% remained in the Prediabetes group and 19% had Normal glucose tolerance (NGT) in 2017. Among the subjects with FPG ≥ 5.6 - 6.0 mmol/L in 2012, 24.7% had Diabetes in 2017, 34.6% - Prediabetes and 40.7% had NGT. The difference in the Diabetes prevalence between the two groups was significant – 50% vs. 24.7% (T=2.443, P Conclusion: The most important conclusion from our screening from 2017 is that ¼ people with FPG ≥ 5.6 – 6.0 mmol/L after a few years became diabetics, so systematic efforts should be directed towards this border group.},
     year = {2021}
    }
    

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    AU  - Anna-Maria Borissova
    AU  - Jordan Vlahov
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    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.cmr.20211003.15
    AB  - The WHO and many other diabetes organizations recommend performing OGTT at fasting plasma glucose ≥ 6.1 ÷ 6.9 mmol/L mmol/L, but ADA indicates a lower cut-off for this parameter - ≥ 5.6 ÷ 6.0 mmol/L mmol/L. Aim: We decided to evaluate the role of baseline glucose tolerance for the development of Diabetes or Prediabetes over time by a prospective study of the changes in glucose tolerance 5 years after the last nationwide cross-sectional study in Bulgaria. Material: The study included 204 subjects from a total of 2033 tested 5 years ago. These 204 individuals were selected among those with a fasting plasma glucose (FPG) 6.1 – 6.9 mmol/L (Group 1) and FPG ≥ 5.6 ÷ 6.0 mmol/L (Group 2) found during the screening in 2012. As a part of the screening in 2017, a standard OGTT was performed (WHO’1999) and HbA1c was determined. Methods: Plasma glucose was measured in all the studies by an automated glucose-oxidase analyzer (Glucose Analyzer II, Beckman Coulter, Inc). HbA1c was determined by immunoturbidimetric method after hemolysis of a whole blood sample. Results: Half of the subjects with FPG 6.1 - 6.9 mmol/L in 2012 had Diabetes during the follow up, 31% remained in the Prediabetes group and 19% had Normal glucose tolerance (NGT) in 2017. Among the subjects with FPG ≥ 5.6 - 6.0 mmol/L in 2012, 24.7% had Diabetes in 2017, 34.6% - Prediabetes and 40.7% had NGT. The difference in the Diabetes prevalence between the two groups was significant – 50% vs. 24.7% (T=2.443, P Conclusion: The most important conclusion from our screening from 2017 is that ¼ people with FPG ≥ 5.6 – 6.0 mmol/L after a few years became diabetics, so systematic efforts should be directed towards this border group.
    VL  - 10
    IS  - 3
    ER  - 

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Author Information
  • Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria

  • Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria

  • Medical University of Sofia, University Hospital of Endocrinology, Clinic of Thyroid and Metabolic Bone Disorders, Sofia, Bulgaria

  • Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria

  • Clinic of Endocrinology, University Hospital Sofiamed, Sofia, Bulgaria

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