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Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases

Received: 13 October 2019     Accepted: 12 November 2019     Published: 17 December 2019
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Abstract

The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.

Published in Clinical Medicine Research (Volume 8, Issue 6)

This article belongs to the Special Issue Globalization and Advances on Non-Communicable Chronic Diseases

DOI 10.11648/j.cmr.20190806.12
Page(s) 137-143
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Natural Killer T Cells, Autoimmune Diseases, Immune System Diseases

References
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Cite This Article
  • APA Style

    Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. (2019). Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clinical Medicine Research, 8(6), 137-143. https://doi.org/10.11648/j.cmr.20190806.12

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    ACS Style

    Carlos Ramirez-Velazquez; Juan Carlos Paredes-Palma; Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin. Med. Res. 2019, 8(6), 137-143. doi: 10.11648/j.cmr.20190806.12

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    AMA Style

    Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin Med Res. 2019;8(6):137-143. doi: 10.11648/j.cmr.20190806.12

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  • @article{10.11648/j.cmr.20190806.12,
      author = {Carlos Ramirez-Velazquez and Juan Carlos Paredes-Palma and Sandra Vanesa Patzi-Vargas},
      title = {Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases},
      journal = {Clinical Medicine Research},
      volume = {8},
      number = {6},
      pages = {137-143},
      doi = {10.11648/j.cmr.20190806.12},
      url = {https://doi.org/10.11648/j.cmr.20190806.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190806.12},
      abstract = {The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.},
     year = {2019}
    }
    

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    AU  - Carlos Ramirez-Velazquez
    AU  - Juan Carlos Paredes-Palma
    AU  - Sandra Vanesa Patzi-Vargas
    Y1  - 2019/12/17
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    N1  - https://doi.org/10.11648/j.cmr.20190806.12
    DO  - 10.11648/j.cmr.20190806.12
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
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    UR  - https://doi.org/10.11648/j.cmr.20190806.12
    AB  - The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.
    VL  - 8
    IS  - 6
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Author Information
  • Allergy Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico

  • Internal Medicine Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico

  • Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico

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