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Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer

Received: 12 May 2018     Accepted: 4 June 2018     Published: 15 June 2018
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Abstract

Background: In the case of large heterogeneity, the data combination of randomized controlled trials will lead to the decrease of the reliability of systematic review and meta analysis, so we conducted the present study. Objectives: To explore sources of heterogeneity in studies on Tai Chi Chuan (TCC) as a complementary and alternative method for managing the overall quality of life of postoperative breast cancer patients. Methods: Randomized controlled trials were searched for in PubMed, EMBASE, Web of Science and the Cochrane Library through August 2017. The Cochrane Handbook 5.2 standards and Stata software version 10.0 were adopted for evaluating the quality of the included studies and the data was analyzed on overall quality of life of TCC. A separate univariate meta-regression analysis was performed on the study duration, sample size, cancer staging, prior breast cancer treatment, different types of TCC intervention group, different types of control group, intervention duration, mean age, and ethnicity to detect important factors leading to heterogeneity. Results: Significant heterogeneity was present in the included studies that used TCC to improve the overall quality of life of postoperative breast cancer patients from the retrieved literature (P < 0.05). The univariate meta-regression analysis indicated that the source of heterogeneity was not apparent in the analyzed factors within or between studies. Conclusions: A normative approach in studies evaluating the use of TCC for improving the overall quality of life of postoperative breast cancer patients was not sufficiently explored in the existing randomized controlled trials (RCTs). An insufficient number of RCTs in this field may be the reason that the effect size had unclear clinical significance. The existing evidence provided limited judgment on sources of heterogeneity between studies evaluating the use of TCC for improving overall quality of life in postoperative breast cancer patients.

Published in Clinical Medicine Research (Volume 7, Issue 3)
DOI 10.11648/j.cmr.20180703.12
Page(s) 57-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Breast Neoplasms, Heterogeneity, Quality of Life, Tai Chi Chuan

References
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  • APA Style

    Yuanqing Pan, Yanxu Yang, Yi Dong, Nan Li, Haiqian Liang, et al. (2018). Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer. Clinical Medicine Research, 7(3), 57-66. https://doi.org/10.11648/j.cmr.20180703.12

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    ACS Style

    Yuanqing Pan; Yanxu Yang; Yi Dong; Nan Li; Haiqian Liang, et al. Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer. Clin. Med. Res. 2018, 7(3), 57-66. doi: 10.11648/j.cmr.20180703.12

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    AMA Style

    Yuanqing Pan, Yanxu Yang, Yi Dong, Nan Li, Haiqian Liang, et al. Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer. Clin Med Res. 2018;7(3):57-66. doi: 10.11648/j.cmr.20180703.12

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  • @article{10.11648/j.cmr.20180703.12,
      author = {Yuanqing Pan and Yanxu Yang and Yi Dong and Nan Li and Haiqian Liang and Qi Cui},
      title = {Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer},
      journal = {Clinical Medicine Research},
      volume = {7},
      number = {3},
      pages = {57-66},
      doi = {10.11648/j.cmr.20180703.12},
      url = {https://doi.org/10.11648/j.cmr.20180703.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180703.12},
      abstract = {Background: In the case of large heterogeneity, the data combination of randomized controlled trials will lead to the decrease of the reliability of systematic review and meta analysis, so we conducted the present study. Objectives: To explore sources of heterogeneity in studies on Tai Chi Chuan (TCC) as a complementary and alternative method for managing the overall quality of life of postoperative breast cancer patients. Methods: Randomized controlled trials were searched for in PubMed, EMBASE, Web of Science and the Cochrane Library through August 2017. The Cochrane Handbook 5.2 standards and Stata software version 10.0 were adopted for evaluating the quality of the included studies and the data was analyzed on overall quality of life of TCC. A separate univariate meta-regression analysis was performed on the study duration, sample size, cancer staging, prior breast cancer treatment, different types of TCC intervention group, different types of control group, intervention duration, mean age, and ethnicity to detect important factors leading to heterogeneity. Results: Significant heterogeneity was present in the included studies that used TCC to improve the overall quality of life of postoperative breast cancer patients from the retrieved literature (P < 0.05). The univariate meta-regression analysis indicated that the source of heterogeneity was not apparent in the analyzed factors within or between studies. Conclusions: A normative approach in studies evaluating the use of TCC for improving the overall quality of life of postoperative breast cancer patients was not sufficiently explored in the existing randomized controlled trials (RCTs). An insufficient number of RCTs in this field may be the reason that the effect size had unclear clinical significance. The existing evidence provided limited judgment on sources of heterogeneity between studies evaluating the use of TCC for improving overall quality of life in postoperative breast cancer patients.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Heterogeneity Factor Analysis of Studies Evaluating the Effect of Tai Chi on Improving the Overall Quality of Life in Patients with Breast Cancer
    AU  - Yuanqing Pan
    AU  - Yanxu Yang
    AU  - Yi Dong
    AU  - Nan Li
    AU  - Haiqian Liang
    AU  - Qi Cui
    Y1  - 2018/06/15
    PY  - 2018
    N1  - https://doi.org/10.11648/j.cmr.20180703.12
    DO  - 10.11648/j.cmr.20180703.12
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 57
    EP  - 66
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20180703.12
    AB  - Background: In the case of large heterogeneity, the data combination of randomized controlled trials will lead to the decrease of the reliability of systematic review and meta analysis, so we conducted the present study. Objectives: To explore sources of heterogeneity in studies on Tai Chi Chuan (TCC) as a complementary and alternative method for managing the overall quality of life of postoperative breast cancer patients. Methods: Randomized controlled trials were searched for in PubMed, EMBASE, Web of Science and the Cochrane Library through August 2017. The Cochrane Handbook 5.2 standards and Stata software version 10.0 were adopted for evaluating the quality of the included studies and the data was analyzed on overall quality of life of TCC. A separate univariate meta-regression analysis was performed on the study duration, sample size, cancer staging, prior breast cancer treatment, different types of TCC intervention group, different types of control group, intervention duration, mean age, and ethnicity to detect important factors leading to heterogeneity. Results: Significant heterogeneity was present in the included studies that used TCC to improve the overall quality of life of postoperative breast cancer patients from the retrieved literature (P < 0.05). The univariate meta-regression analysis indicated that the source of heterogeneity was not apparent in the analyzed factors within or between studies. Conclusions: A normative approach in studies evaluating the use of TCC for improving the overall quality of life of postoperative breast cancer patients was not sufficiently explored in the existing randomized controlled trials (RCTs). An insufficient number of RCTs in this field may be the reason that the effect size had unclear clinical significance. The existing evidence provided limited judgment on sources of heterogeneity between studies evaluating the use of TCC for improving overall quality of life in postoperative breast cancer patients.
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Department of Medical Psychology, Department of Public Course, Tianjin Medical College, Tianjin, China

  • Department of Public Health, Tianjin Medical College, Tianjin, China

  • Department of Pharmacy, Tianjin Medical College, Tianjin, China

  • Nursing Department of Neurosurgery, Tianjin Pingjin Hospital, Tianjin, China

  • Department of Neurosurgery, Tianjin Pingjin Hospital, Tianjin, China

  • The Department of Clinical Pathway and Quality Control the Frist Affiliated Hospital of Lanzhou University, Lanzhou, China

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