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Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia

Received: 21 February 2017     Accepted: 21 March 2017     Published: 10 April 2017
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Abstract

Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.

Published in Clinical Medicine Research (Volume 6, Issue 3)
DOI 10.11648/j.cmr.20170603.14
Page(s) 80-85
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Experimental Methodology, Anesthetics, Myocardial Ischemia-Reperfusion, Inflammatory Factor

References
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Cite This Article
  • APA Style

    Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. (2017). Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clinical Medicine Research, 6(3), 80-85. https://doi.org/10.11648/j.cmr.20170603.14

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    ACS Style

    Weiting Wang; Chunhua Hao; Rui Zhang; Yinzhong Ma; Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin. Med. Res. 2017, 6(3), 80-85. doi: 10.11648/j.cmr.20170603.14

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    AMA Style

    Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin Med Res. 2017;6(3):80-85. doi: 10.11648/j.cmr.20170603.14

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  • @article{10.11648/j.cmr.20170603.14,
      author = {Weiting Wang and Chunhua Hao and Rui Zhang and Yinzhong Ma and Shuangyong Sun and Zhuanyou Zhao and Lida Tang},
      title = {Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia},
      journal = {Clinical Medicine Research},
      volume = {6},
      number = {3},
      pages = {80-85},
      doi = {10.11648/j.cmr.20170603.14},
      url = {https://doi.org/10.11648/j.cmr.20170603.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.14},
      abstract = {Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia
    AU  - Weiting Wang
    AU  - Chunhua Hao
    AU  - Rui Zhang
    AU  - Yinzhong Ma
    AU  - Shuangyong Sun
    AU  - Zhuanyou Zhao
    AU  - Lida Tang
    Y1  - 2017/04/10
    PY  - 2017
    N1  - https://doi.org/10.11648/j.cmr.20170603.14
    DO  - 10.11648/j.cmr.20170603.14
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 80
    EP  - 85
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20170603.14
    AB  - Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.
    VL  - 6
    IS  - 3
    ER  - 

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Author Information
  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

  • State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

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