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Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions

Received: 20 February 2016     Accepted: 25 April 2016     Published: 13 May 2016
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Abstract

We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.

Published in Clinical Medicine Research (Volume 5, Issue 3)
DOI 10.11648/j.cmr.20160503.15
Page(s) 39-44
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Tablets, CO2-Extracts, Quality Indicators, Camphor, Carotenoids, Acorus Calamus, Calendula Officinalis

References
[1] State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t. 1, 2.2.25.
[2] State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t., 2.2.27.
[3] State Pharmacopoeia of the Republic of Kazakhstan (SF) RK І, t., 2.2.28.
[4] Kasyanov G. I., Mkhitaryants G. A. Sub - and supercritical CO2-extraction of valuable components from vegetable raw materials // Collection of materials of the international scientific and technical Internet conference "The Sub — and Supercritical Fluid Technologies in the Food Industry". – Krasnodar: KubGTU, 2012. – P. 80-83.
[5] Ustenova G. O. Extraction by the liquefied gases. – Manual, Almaty: КаzNMU, 2010. – 66 p.
[6] Kasyanov G. I. CO2-extracts. Production and application. – Monograph: Under the editorship of the prof. Scherbakov V. G. – Krasnodar: Ecoinvestment, 2010. – 176 p.
[7] Ibadullayeva G. S., Pichkhadze G. M., Ustenova G. O., Dilbarkhanov R., Tikhonova S. A., Grudko V. A., Bevz N. Y., Yudina Yu. V. The Chemical composition of CO2–extract of the Acorus marsh, received in subcritical conditions // The Chemical and pharmaceutical magazine. – M, 2015. - No. 5. – P. 56-60.
[8] Ibadullayeva G. S., Bochkhaeva A. K., Ustenova G. O., Datkhayev U. M., Sakipova Z. B., Tikhonova S. A., Grudko V. A., Bevz N. Y. Standardization of Calamus CO2-extract and study of individual fractions of herbal preparations // Life Science Journal. – 2014. - №11 (5s) // http://www // Life Science Journal. – 2014. - №11(2s). - P. 25-27.
[9] Shikov A. N., Makarov G. V., Ryzhenkov V. E. Vegetable oils and oil extracts: technology, standardization, properties. - M.: Publishing House. Home "Russian doctor". - 2004.
[10] Tinctures, extracts, elixirs and standardization / edited by Bagirova V. L. and A. V. Severtsev – St. P: Specialized Literature, 2001.
[11] Stasyeva Oksana Nikolaevna. Improvement of technology of production and application of CO2-extracts from vegetable raw materials: the dissertation... of candidate of technical sciences: 05.18.10. - Krasnodar, 2005. - 153 p.
[12] Savin, Vladimir Nikolayevich. The improving technology for obtaining valuable components from vegetative raw materials with environmentally safe physical methods: dissertation... of candidate of technical sciences: 05.18.01 Krasnodar, 2006. - 163 p.
[13] Kasyanov G. I., Malashenko N. L., Silinskaya S. M. Technics and Technology of using carbon dioxide as the extracting medium // News of University. Food technology. 2014. – N. 4. - P. 6-9.
[14] Kasyanov G. I. Technics and Technology of using carbon dioxide in sub- and supercritical state // Bulletin of the Voronezh state University of engineering technologies. 2014. - No. 1. - P. 130-135.
[15] Gavashelishvili, L. V. Development of composition and technology of lingual tablets containing chlorophyllipt thick extract and thyme liquid extract: the dissertation... of candidate of pharmaceutical sciences: 14.04.01 / Gavashelishvili Lali Vasilyevna; [a defence place: "Pyatigorsk state pharmaceutical academy"]. - Pyatigorsk, 2011. - 122 p.
[16] Development of the technology of granules of Linden extract, pills of extract hibiscus and rosehip extract: abstract of thesis... candidate of pharmaceutical sciences: 15.00.01 / Paleskin Anatoly Vladimirovich; [a defence place: St. - Petersburg state chem.-pharmacist. acad.] - St. Petersburg, 2009. - 29 P.
[17] The draft of Provisional Analytic Normative Document (PAND) Extract of the Calamus.
[18] The draft of Provisional Analytic Normative Document (PAND) Extract of the Calendula.
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  • APA Style

    Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. (2016). Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clinical Medicine Research, 5(3), 39-44. https://doi.org/10.11648/j.cmr.20160503.15

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    ACS Style

    Galiya Ibadullayeva; Volodimir Grudko; Аssyl Boshkayeva; Zuriyadda Sakipova; Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin. Med. Res. 2016, 5(3), 39-44. doi: 10.11648/j.cmr.20160503.15

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    AMA Style

    Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, et al. Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions. Clin Med Res. 2016;5(3):39-44. doi: 10.11648/j.cmr.20160503.15

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  • @article{10.11648/j.cmr.20160503.15,
      author = {Galiya Ibadullayeva and Volodimir Grudko and Аssyl Boshkayeva and Zuriyadda Sakipova and Talgat Dzalgasbayev and Gulbaram Ustenova and Kaldanay Kozhanova and Nazerke Uristemkhankyzy and Eduard Bissenbaev and Nurgan Tussupova and Sholpan Mulkibayeva and Ilyas Tazabekov},
      title = {Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions},
      journal = {Clinical Medicine Research},
      volume = {5},
      number = {3},
      pages = {39-44},
      doi = {10.11648/j.cmr.20160503.15},
      url = {https://doi.org/10.11648/j.cmr.20160503.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20160503.15},
      abstract = {We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions
    AU  - Galiya Ibadullayeva
    AU  - Volodimir Grudko
    AU  - Аssyl Boshkayeva
    AU  - Zuriyadda Sakipova
    AU  - Talgat Dzalgasbayev
    AU  - Gulbaram Ustenova
    AU  - Kaldanay Kozhanova
    AU  - Nazerke Uristemkhankyzy
    AU  - Eduard Bissenbaev
    AU  - Nurgan Tussupova
    AU  - Sholpan Mulkibayeva
    AU  - Ilyas Tazabekov
    Y1  - 2016/05/13
    PY  - 2016
    N1  - https://doi.org/10.11648/j.cmr.20160503.15
    DO  - 10.11648/j.cmr.20160503.15
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 39
    EP  - 44
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20160503.15
    AB  - We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.
    VL  - 5
    IS  - 3
    ER  - 

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Author Information
  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, National Pharmaceutical University, Kharkov, Ukraine

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

  • Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

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