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Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals

Received: 17 May 2015     Accepted: 7 June 2015     Published: 4 July 2015
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Abstract

Objectives: Determine the frequency of malignancies diagnosed in myelogram seen in hematology services of Campus and Sylvanus Olympio Teaching Hospitals in Lome from 1992 to 2013. Study the epidemiology profile of these diseases. Materials and methods: It was an analytical retrospective study of 469 cases of malignancies diagnosed in 1511 myelograms during 21 years in both teaching hospital of Lome. Results: Blood disorders represent 31.70% of the results of myelogram performed during 21 years in the Teaching Hospital of Lome. Each year, there is an average of 22.3 cases diagnosed hematological malignancies. The most hematological malignancies were Kahler's disease (28.57%), chronic myeloid leukemia (24.52%), chronic lymphocytic leukemia (22.17%), acute lymphoblastic leukemia (12.58%) and acute myeloid leukemia (8.10%). Other (4.05%) were represented by the essential hypereosinophilic syndrome (4 cases), hairy cell leukemia (4 cases), Sezary lymphoma (3 cases), essential thrombocythemia (3 cases), Waldenstrom's disease (2 cases), acute myelomonocytic leukemia (1 case), prolymphocytic leukemia (1 case) and plasma cell leukemia (1 case). By gender, the CLL is most predominant in women against CML in men. Hemopathies were observed at all ages of life. Conclusion: Hematological malignancies are diagnosed in the Teaching Hospital of Campus and Sylvanus Olympio in Lome with a high relatively frequency. This prevalence must be higher if all cases of malignancies diagnosed in Togo were recorded in a national cancer register. This study aims to knowledge of epidemiological aspects of hematological malignancies and improve the care of patients with hematological malignancies by the provision of adequate anti-mitotic drugs.

Published in Clinical Medicine Research (Volume 4, Issue 4)
DOI 10.11648/j.cmr.20150404.14
Page(s) 111-115
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hematological Malignancies, Frequency, Epidemiology, Togo

References
[1] Mahon F-X. Leucémie myéloïde chronique et inhibition de la tyrosine kinase. Rev Med Interne 2001; 22: 894-9
[2] Bories D. Physiopathologie moléculaire de la leucémie myéloïde chronique. Hématologie 2001;7:6-12.
[3] Lokrou A, Toutou T, Diallo A, Groga-Bada, Ouedraogo Y, Koutouan A, Tea N, Niamkey E, Soubeyrand J, Beda Y. Leucose et Lymphomes dans un service de Médecine Interne à Abidjan. Med; Afr. Noire, 1988, 35 (4), 305-310.
[4] Toutou T. Contribution à l’étude du myélome multiple en milieu africain. A propos de 24 cas dont 22 autochtones. Thèse : Méd : Abidjan : 1981 ; 313.
[5] Segbena A.Y. Contribution à l’étude des hémopathies lymphoïdes malignes chez le Noir Africain. Thèse : Abidjan : 1991, 1261.
[6] Koffi K.G, Sanogo I, Trazo D, Toure A.H, Tolo A, N'Guessan K, Danho N.C, Kouakou N, Sangare A. Caractéristiques du myélome multiple du noir africain. Expérience de la Côte d'Ivoire, Méd. Afr. Noire, 2000, vol. 47, n° 10 , pp. 430 – 435.
[7] Marie J.P, Delmer A, Herait P. Hématologie pratique Impact–Internat 1992,139-203
[8] Atinoto K. Profil clinique, biologique et thérapeutique de la leucémie lymphoïde chronique dans les CHU de Lomé. Mém Ass Med : Lomé 2000 ; pp 25-47.
[9] Guihot F. Chronic myeloid leukaemia. Textbook of malignant haematology (1999).
[10] Dokekias E.A, Malanda F. La leucémie myéloïde chronique quel avenir thérapeutique en Afrique noire ? Revue : Tunisie médicale. [Tunis. méd.] , 2003, vol. 81, no 3, pp. 172 – 179
[11] Zittoun R, Samama M, Marie J.P. Leucémies et états apparentés In : Manuel d’Hématologie Paris : Doin : 1988 ; 397-427.
[12] Yao T, Tea D.N, Rain J.D. Leucémie lymphoïde chronique en Côte d’Ivoire. Méd. Trop. 51,4, oct.-déc. 1991, 417-420.
[13] Tea D, Yao T, Rain J D. Aspects particuliers de la leucémie lymphoïde chronique (L.L.C.) en Côte d’Ivoire Rev. Méd. Côte d’Ivoire, 1982, 16, (57), 37-40.
[14] Carli P M, Milan C, Bordes M, Bonhomme J. Etude de l’incidence de la leucémie lymphoïde chronique dans le département de la Côte d’Or. Nouv. Rev. Fr. hémato, 1986, 28, 23-26.
[15] Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet J L. The French Cooperative Group on CLL: B-cell chronic lymphocytic leukaemia. Present status and future direction. Blood 1991; 78: 1901.
[16] Desablens B. Leucémie lymphoïde chronique. Diagnostic, évolution et pronostic. Rev. Prat. (Paris), 1990, 40, (23), 2195-2198.
[17] Vernant J.P, Brun B. Leucémies aiguës. In : Hématologie Paris : Flammarion : 1986 ; pp. 471-504.
[18] Dokekias E.A, Bidzouta-Matingou P, Malanda F, Ntsihou D, Nzingoula S, SANOGO L. Configuration épidémiologique et cytologique des leucémies aiguës au Centre Hospitalier et Universitaire de Brazzaville, Revue : Tunisie médicale. [Tunis. méd.], 2004, vol. 82, no 11, pp. 1019 – 1025.
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    Irenee Messanh Kueviakoe, Essohana Padaro, Kossi Agbetiafa, Yao Layibo, Malewe Kolou, et al. (2015). Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals. Clinical Medicine Research, 4(4), 111-115. https://doi.org/10.11648/j.cmr.20150404.14

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    ACS Style

    Irenee Messanh Kueviakoe; Essohana Padaro; Kossi Agbetiafa; Yao Layibo; Malewe Kolou, et al. Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals. Clin. Med. Res. 2015, 4(4), 111-115. doi: 10.11648/j.cmr.20150404.14

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    AMA Style

    Irenee Messanh Kueviakoe, Essohana Padaro, Kossi Agbetiafa, Yao Layibo, Malewe Kolou, et al. Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals. Clin Med Res. 2015;4(4):111-115. doi: 10.11648/j.cmr.20150404.14

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  • @article{10.11648/j.cmr.20150404.14,
      author = {Irenee Messanh Kueviakoe and Essohana Padaro and Kossi Agbetiafa and Yao Layibo and Malewe Kolou and Ahoefa Vovor and Akuete Yvon Segbena},
      title = {Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals},
      journal = {Clinical Medicine Research},
      volume = {4},
      number = {4},
      pages = {111-115},
      doi = {10.11648/j.cmr.20150404.14},
      url = {https://doi.org/10.11648/j.cmr.20150404.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20150404.14},
      abstract = {Objectives: Determine the frequency of malignancies diagnosed in myelogram seen in hematology services of Campus and Sylvanus Olympio Teaching Hospitals in Lome from 1992 to 2013. Study the epidemiology profile of these diseases. Materials and methods: It was an analytical retrospective study of 469 cases of malignancies diagnosed in 1511 myelograms during 21 years in both teaching hospital of Lome. Results: Blood disorders represent 31.70% of the results of myelogram performed during 21 years in the Teaching Hospital of Lome. Each year, there is an average of 22.3 cases diagnosed hematological malignancies. The most hematological malignancies were Kahler's disease (28.57%), chronic myeloid leukemia (24.52%), chronic lymphocytic leukemia (22.17%), acute lymphoblastic leukemia (12.58%) and acute myeloid leukemia (8.10%). Other (4.05%) were represented by the essential hypereosinophilic syndrome (4 cases), hairy cell leukemia (4 cases), Sezary lymphoma (3 cases), essential thrombocythemia (3 cases), Waldenstrom's disease (2 cases), acute myelomonocytic leukemia (1 case), prolymphocytic leukemia (1 case) and plasma cell leukemia (1 case). By gender, the CLL is most predominant in women against CML in men. Hemopathies were observed at all ages of life. Conclusion: Hematological malignancies are diagnosed in the Teaching Hospital of Campus and Sylvanus Olympio in Lome with a high relatively frequency. This prevalence must be higher if all cases of malignancies diagnosed in Togo were recorded in a national cancer register. This study aims to knowledge of epidemiological aspects of hematological malignancies and improve the care of patients with hematological malignancies by the provision of adequate anti-mitotic drugs.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Hematological Malignancies: Analysis of Myelogram Results over 21 Years in Lome Teaching Hospitals
    AU  - Irenee Messanh Kueviakoe
    AU  - Essohana Padaro
    AU  - Kossi Agbetiafa
    AU  - Yao Layibo
    AU  - Malewe Kolou
    AU  - Ahoefa Vovor
    AU  - Akuete Yvon Segbena
    Y1  - 2015/07/04
    PY  - 2015
    N1  - https://doi.org/10.11648/j.cmr.20150404.14
    DO  - 10.11648/j.cmr.20150404.14
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 111
    EP  - 115
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20150404.14
    AB  - Objectives: Determine the frequency of malignancies diagnosed in myelogram seen in hematology services of Campus and Sylvanus Olympio Teaching Hospitals in Lome from 1992 to 2013. Study the epidemiology profile of these diseases. Materials and methods: It was an analytical retrospective study of 469 cases of malignancies diagnosed in 1511 myelograms during 21 years in both teaching hospital of Lome. Results: Blood disorders represent 31.70% of the results of myelogram performed during 21 years in the Teaching Hospital of Lome. Each year, there is an average of 22.3 cases diagnosed hematological malignancies. The most hematological malignancies were Kahler's disease (28.57%), chronic myeloid leukemia (24.52%), chronic lymphocytic leukemia (22.17%), acute lymphoblastic leukemia (12.58%) and acute myeloid leukemia (8.10%). Other (4.05%) were represented by the essential hypereosinophilic syndrome (4 cases), hairy cell leukemia (4 cases), Sezary lymphoma (3 cases), essential thrombocythemia (3 cases), Waldenstrom's disease (2 cases), acute myelomonocytic leukemia (1 case), prolymphocytic leukemia (1 case) and plasma cell leukemia (1 case). By gender, the CLL is most predominant in women against CML in men. Hemopathies were observed at all ages of life. Conclusion: Hematological malignancies are diagnosed in the Teaching Hospital of Campus and Sylvanus Olympio in Lome with a high relatively frequency. This prevalence must be higher if all cases of malignancies diagnosed in Togo were recorded in a national cancer register. This study aims to knowledge of epidemiological aspects of hematological malignancies and improve the care of patients with hematological malignancies by the provision of adequate anti-mitotic drugs.
    VL  - 4
    IS  - 4
    ER  - 

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Author Information
  • Faculty of Health Sciences, University of Lome, Lome, Togo

  • Faculty of Health Sciences, University of Lome, Lome, Togo

  • Faculty of Health Sciences, University of Lome, Lome, Togo

  • Hematology Laboratory of Campus Teaching Hospital of Lome, Lome, Togo

  • Faculty of Health Sciences, University of Lome, Lome, Togo

  • Faculty of Health Sciences, University of Lome, Lome, Togo

  • Faculty of Health Sciences, University of Lome, Lome, Togo

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